Results 111 to 120 of about 2,516,709 (214)

CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. [PDF]

EBioMedicine, 2023
Yan J, Kothur K, Mohammad S, Chung J, Patel S, Jones HF, Keating BA, Han VX, Webster R, Ardern-Holmes S, Antony J, Menezes MP, Tantsis E, Gill D, Gupta S, Kandula T, Sampaio H, Farrar MA, Troedson C, Andrews PI, Pillai SC, Heng B, Guillemin GJ, Guller A, Bandodkar S, Dale RC.   +25 more
europepmc   +1 more source

Quinolinic Acid [PDF]

, 2020
openaire   +1 more source

A history of suicide attempts among individuals with schizophrenia is associated with tryptophan degradation via the salivary kynurenine pathway

BMC Psychiatry
Background Tryptophan, an essential precursor metabolite within the kynurenine pathway, has been implicated in the neurobiological mechanisms underlying both schizophrenia and associated suicidality. Despite this link, the lack of validated biomarkers to
Yi Yin, Ting Xie, Jinghui Tong, Junchao Huang, Baopeng Tian, Mengzhuang Gou, Song Chen, Shuping Tan, Zhiren Wang, Yongsheng Tong, Yanfang Zhou, Leilei Wang, Yunlong Tan   +12 more
doaj   +1 more source

The role of the kynurenine pathway in the pathogenesis of pain and affective disorders after traumatic brain injury

Brain, Behavior, & Immunity - Health
Traumatic brain injury (TBI) alters neuroimmune physiology resulting in an imbalance between pro- and anti-inflammatory cascades. Whereas acute inflammation serves as an adaptive defense mechanism of the innate immune system to promote healing and ...
Itzick Nahmoud, Karli Monahan, Eric A. Woodcock, Alana C. Conti   +3 more
doaj   +1 more source

The mechanism of quinolinic acid-induced neurite lesions: The role of NR2B, ROS and autophagy

, 2022
Increased quinolinic acid (QA) has been suggested in various mental disease pathology. Excessive QA is shown to overactivate N-Methyl-D-aspartic acid (NMDA) receptor subunit 2B (NR2B) receptors and is deleterious to the neurons; however, the exact ...
Yuanyi Xie (20166906)
core  

Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.

, 2002
A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins.
Brundin, Patrik, Petersén, Åsa, Puschban, Zoe, DiFiglia, M, Chase, K, Aronin, N   +5 more
core   +1 more source

Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process. [PDF]

Biol Direct, 2023
Dongol A, Chen X, Zheng P, Seyhan ZB, Huang XF.   +4 more
europepmc   +1 more source

Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. [PDF]

J Clin Invest, 2023
Watne LO, Pollmann CT, Neerland BE, Quist-Paulsen E, Halaas NB, Idland AV, Hassel B, Hassel B, Henjum K, Knapskog AB, Frihagen F, Raeder J, Godø A, Ueland PM, McCann A, Figved W, Selbæk G, Zetterberg H, Fang EF, Myrstad M, Giil LM.   +20 more
europepmc   +1 more source

Exploring the neuroprotective effects of montelukast on brain inflammation and metabolism in a rat model of quinolinic acid-induced striatal neurotoxicity. [PDF]

J Neuroinflammation, 2023
Tassan Mazzocco M, Murtaj V, Martins D, Schellino R, Coliva A, Toninelli E, Vercelli A, Turkheimer F, Belloli S, Moresco RM.   +9 more
europepmc   +1 more source

Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer

Clinical and Translational Medicine
Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage non‐small‐cell lung cancer (NSCLC), but it has not consistently yielded durable responses.
Ailing Cao, Yaobin Lin, Shaoxing Guan, Youhao Chen, Wenyu Zhai, Yuheng Zhou, Shoucheng Feng, Yanping Guan, Yiyu Zhang, Min Huang, Xueding Wang, Hao Long   +11 more
doaj   +1 more source