Results 91 to 100 of about 3,281,166 (203)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition

Frontiers in Molecular Biosciences, 2019
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips, Robert S. Phillips, Emma Carine Iradukunda, Tamera Hughes, J. Phillip Bowen   +4 more
doaj   +1 more source

QUINOLINIC ACID METABOLISM

Journal of Biological Chemistry, 1949
L.M. Henderson, G.B. Ramasarma
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3-hydroxykynurenine, xanthurenic acid, quinolinic acid, the kynurenine-to-tryptophan ratio and survival.

, 2020
Predicted estimates from Cox regression with age, gender, current smoking, estimated glomerular filtration rate, diabetes mellitus, C-reactive protein and pyridoxal 5’phosphate as covariates.
Per Magne Ueland (146309), Øivind Midttun (542701), Arve Ulvik (749228), Grete Slettom (7423286), Eva Kristine Ringdal Pedersen (8282676), Ottar Nygård (425679), Lasse Melvaer Giil (6823709), Anders Lund (744740), Jan Erik Nordrehaug (7448921), Stein-Erik Hafstad Solvang (8282673)   +9 more
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Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.

, 2002
A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins.
Brundin, Patrik, Petersén, Åsa, Puschban, Zoe, DiFiglia, M, Chase, K, Aronin, N, Brundin, Patrik,, Petersén, Åsa,, Puschban, Zoe,, Lund University., K. Chase, N. Aronin, Å. Petersén, P. Brundin, Z. Puschban, M. DiFiglia   +15 more
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Pyridinedicarboxylic Acid Derivatives of Dichlorobis(cyclopentadienyl)titanium(IV)

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)titanium(IV) with pyridine dicarboxylic acids viz. quinolinic acid (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +1 more source

Some New Derivatives of Organozirconium(IV) with Pyridinedicarboxylic Acids

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)zirconium(IV) with pyridinedicarboxylic acids viz. quinolinic acids (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +1 more source

Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes [PDF]

, 2005
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Newcombe, J, Kalina, P, Kepplinger, B, Baran, H, Ferraz-Leite, H, Kainz, A   +5 more
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Cyclosporin A And Bcl-2 Do Not Inhibit Quinolinic Acid-induced Striatal Excitotoxicity In Rodents.

, 2015
Mitochondrial permeability transition (MPT) is a nonselective inner membrane permeabilization that contributes to neuronal cell death under circumstances such as brain trauma, ischemia, and hypoglycemia. Here we study the participation of MPT and the Bcl-
Brundin, Patrik, Maciel, Evelise N, Kaminski Schierle, Gabriele S, Castilho, Roger F, Hansson, Oskar   +4 more
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Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine

, 2019
International audienceMajor depressive disorder is a complex multifactorial condition with a so far poorly characterized underlying pathophysiology. Consequently, the available treatments are far from satisfactory as it is estimated that up to 30% of ...
de Medeiros, Gabriela Ferreira, Abdel-Ahad, Pierre, Langeron, Olivier, van Steenwinckel, Juliette, Verdonk, Franck, Petit, Anne-Cécile, Blatzer, Michael, Launay, Jean-Marie, Maignan, Anna, Gaillard, Raphael, Sharshar, Tarek, de Maricourt, Pierre, Vinckier, Fabien, Callebert, Jacques, Chrétien, Fabrice, Jouvion, Gregory, Danckaert, Anne, Jean-Marie Launay, Franck Verdonk, Tarek Sharshar, Gregory Jouvion, Gabriela Ferreira De Medeiros, Raphael Gaillard, Anne-Cécile Petit, Fabien Vinckier, Pierre de Maricourt, Fabrice Chrétien, Juliette Van Steenwinckel, Anna Maignan, Anne Danckaert, Jacques Callebert, Michael Blatzer, Olivier Langeron, Pierre Abdel-Ahad   +33 more
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Estudo dos mecanismos envolvidos no efeito neuroprotetor do pré-condicionamento com N-Metil-D-Aspartato (NMDA) [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.O pré-condicionamento cerebral é caracterizado por um estado de tolerância transitória do tecido ...
Constantino, Leandra Celso
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