Results 71 to 80 of about 15,449 (218)

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: Role in excitotoxicity

Neurobiology of Disease, 2009
Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to ...
Xavier Xifró, Albert Giralt, Ana Saavedra, Juan M. García-Martínez, Miguel Díaz-Hernández, José J. Lucas, Jordi Alberch, Esther Pérez-Navarro   +7 more
doaj   +1 more source

Kynurenine pathway metabolites selectively associate with impaired associative memory function in depression

Brain, Behavior, & Immunity - Health, 2020
Activation of the kynurenine pathway (KP), an important downstream effect of inflammation, is a driver of depression and neurodegeneration. Damage from the end product of KP activation, quinolinic acid, may be responsible specifically for impairment in ...
Margherita Chirico, James Custer, Ifeoluwa Shoyombo, Crystal Cooper, Sheila Meldrum, Robert Dantzer, Madhukar H. Trivedi, Paul Rathouz, Marisa S. Toups   +8 more
doaj   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Mary Heng, Peter Detloff, Phillip Wang, Roger Albin   +4 more
core   +1 more source

Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?

Journal of Translational Medicine, 2018
Background Immune checkpoint inhibitors have revolutionized the treatment paradigm of highly lethal malignancies like advanced non-small cell lung cancer (NSCLC), demonstrating long-term tumour control and extended patient survival.
Andrea Botticelli, Bruna Cerbelli, Luana Lionetto, Ilaria Zizzari, Massimiliano Salati, Annalinda Pisano, Mazzuca Federica, Maurizio Simmaco, Marianna Nuti, Paolo Marchetti   +9 more
doaj   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortex [PDF]

, 2018
Drug-induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments with drug availability. Drug-related memory depends on persistent changes in dopamine-glutamate interactions in the medial pre-
Carbó Gas, María, Gil-Miravet, Isis, Guarque-Chabrera, Julian, MIQUEL, MARTA, Olucha-Bordonau, Francisco E   +4 more
core   +2 more sources

Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats

Neural Plasticity, 2016
Tryptophan is an essential dietary amino acid that is necessary for protein synthesis, but also serves as the precursor for serotonin. However, in addition to these biological functions, tryptophan also serves as a precursor for the kynurenine pathway ...
Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill   +2 more
doaj   +1 more source

Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect

Journal of Child Psychology and Psychiatry, EarlyView.
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Hanna C. Gustafsson, Hanna R. Wright, Jorden E. Jacinto Schreeder, Joel T. Nigg, Elinor L. Sullivan   +4 more
wiley   +1 more source

Quinoline-2-carbonitrile–fumaric acid (1/0.5) [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
تتكون الوحدة غير المتماثلة لمركب العنوان، C(10)H(6)N(2)·0.5C(4)H(4)O(4)، من مول- إيكول واحد من الكينولين-2 -كاربونيتريل ونصف مول- إيكول من حمض الفوماريك، الذي يقع على مركز الانقلاب. تكون جزيئات الكينولين-2 - كاربونيتريل مستوية تقريبًا، مع انحراف قدره 0.008 (1) Å. يرتبط الحمض والقاعدة معًا عبر أزواج من الروابط الهيدروجينية C - H½O و O - H½N بين الجزيئات،
Wan-Sin Loh, Ching Kheng Quah, Madhukar Hemamalini, Hoong‐Kun Fun   +3 more
openaire   +2 more sources