Results 71 to 80 of about 3,281,166 (203)
The mechanism of quinolinic acid-induced neurite lesions: The role of NR2B, ROS and autophagy
, 2022 Increased quinolinic acid (QA) has been suggested in various mental disease pathology. Excessive QA is shown to overactivate N-Methyl-D-aspartic acid (NMDA) receptor subunit 2B (NR2B) receptors and is deleterious to the neurons; however, the exact ...
Yuanyi Xie (20166906)
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Integrative Zoology, EarlyView.Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu +3 more
wiley +1 more source
, 1990 Extracellular concentrations of the brain metabolite quinolinic acid, an endogenous excitotoxin, were monitored by microdialysis in rat neostriatum and hippocampus/cortex during and following a 30-min period of insulin-induced hypoglycaemia.
Wieloch, T. +18 more
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BMAL1 in Anterior Cingulate Cortex Pyramidal Neurons Relieves Pulpitis‐Induced Nocturnal Pain
International Endodontic Journal, EarlyView.ABSTRACT Aim Nocturnal exacerbation of pulpitis‐induced pain severely disrupts patients' sleep and quality of life, increasing emergency dental care burden. However, the exact mechanisms underlying nocturnal pain remain poorly understood, limiting the development of targeted analgesic strategies.
Yuting Bai +8 more
wiley +1 more source
Nitric oxide synthase inhibitors protect cholinergic neurons against quinolinic acid toxicity in the rat brain [PDF]
Archives of Biological Sciences, 2013 The aim of this study was to examine the effects of intrastriatally injected nitric oxide synthase (NOS) inhibitors, Nω-nitro-l-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), on quinolinic acid (QA)-induced toxicity in selective vulnerable
Stevanović Ivana +2 more
doaj +1 more source
Delayed Increases in Regional Brain Quinolinic Acid Follow Transient Ischemia in the Gerbil
, 1990 Excessive activity or release of excitatory amino acids has been implicated in the neuronal injury that follows transient cerebral ischemia. To investigate the metabolism of the endogenous excitotoxin, quinolinic acid, and its potential for mediating ...
Thaddeus S. Nowak, Melvyn P. Heyes
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The FASEB Journal, Volume 40, Issue 22, 30 November 2026.Declining estrogen signaling may promote inflammaging and cellular senescence/SASP, which converge on blood–brain barrier disruption, glial activation, and neuroimmune dysfunction, thereby increasing vulnerability to depression after menopause. This graphical abstract presents a candidate, hypothesis‐generating model rather than an established causal ...
Lan Zhang, Yao Yao, Xiaoyu Cai
wiley +1 more source
Estudo das Vias de Sinalização Envolvidas no Pré-condicionamento com N-Metil-D-Aspartato (NMDA) sobre Convulsões Induzidas por Ácido Quinolínico em Camundongos [PDF]
, 2008 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.O pré-condicionamento cerebral se refere a um estado de tolerância transitória do tecido nervoso a um estimulo letal evocado por um insulto moderado prévio ...
Herculano, Bruno
core
, 1995 Injection of quinolinic acid in the rat striatum mimics neurochemical changes observed in Huntington's disease. We previously demonstrated that intrastriatal transplantation of fetal striatum or gelfoam protects against toxicity induced by a subsequent ...
Przedborski, S. +7 more
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Kynurenines link chronic inflammation to functional decline and physical frailty
JCI Insight, 2020 Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood.
Reyhan Westbrook +15 more
doaj +1 more source