Results 81 to 90 of about 2,516,709 (214)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition

Frontiers in Molecular Biosciences, 2019
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips, Robert S. Phillips, Emma Carine Iradukunda, Tamera Hughes, J. Phillip Bowen   +4 more
doaj   +1 more source

Maternal Perinatal Gut Microbiome Is Shaped by Traditional Farming Lifestyle and Associated With Early Childhood Atopic Disease

Allergy, EarlyView.
We assessed whether the maternal perinatal gut microbiome and serum SCFA and cord blood SCFA differ between traditional farming and urban dyads. Women following a farming lifestyle had increased microbial diversity, several differentially abundant bacterial species and functional pathways, and increased circulating SCFA. Overall maternal gut microbiome
Erin C. Davis, Courtney M. Jackson, Nichole S. Diaz, Jazmine Susana, Ashley Nelson, Richard Insel, Antti E. Seppo, Kirsi M. Järvinen   +7 more
wiley   +1 more source

Chronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degeneration

, 1993
The excitotoxic hypothesis of Huntington's disease pathogenesis suggests that selective striatal neuronal loss results from excessive activation of striatal excitatory amino acid receptors.
Albin, Roger L., Becker, Jill B., Bazzett, Terence J., Kaatz, Kevin W.   +3 more
core   +1 more source

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Barrett, M.P., Stone, T.W., Bradley, B.M., Kennedy, P.G.E., Rodgers, J.   +4 more
core   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Extracellular levels of quinolinic acid are moderately increased in rat neostriatum following severe insulin-induced hypoglycaemia

, 1990
Extracellular concentrations of the brain metabolite quinolinic acid, an endogenous excitotoxin, were monitored by microdialysis in rat neostriatum and hippocampus/cortex during and following a 30-min period of insulin-induced hypoglycaemia.
Wieloch, T., Westerberg, E., Magnusson, K., Schwarcz, R., Speciale, C., Ungerstedt, U.   +5 more
core   +1 more source

Microbiome‐Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The graphical abstract illustrates how microbiome‐derived indoles activate the aryl hydrocarbon receptor to restore the intestinal barrier. The picture contrasts the “leaky gut” state with the restored homeostasis achieved through AMPK, Nrf2, and IL‐22 signaling.
Mohammad Ali Mahdiabadi, Asma Moghaddam, Nafiseh Erfanian   +2 more
wiley   +1 more source

Quantitative assessment of quinolinic acid-induced striatal toxicity in rats using radioligand binding assays.

, 1994
To validate specific, sensitive and quantitative markers of the rat model of Huntington's disease produced by the intrastriatal injection of quinolinic acid, we used striatal homogenate binding assays for [3H]MK-801-labelled N-methyl-D-aspartate ...
Levivier, M., Przedborski, S., Togasaki, D.M., Maloteaux, J.M., Brotchi, J., Holemans, S.   +5 more
core   +1 more source

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Major Depressive Disorder Signatures: A Review of Artificial Intelligence (AI)‐Powered Insights Into Gut Dysbiosis

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Major Depressive Disorder (MDD) is a highly common neuropsychiatric disorder globally. A variety of factors contribute to the neuropathology of MDD. Microbiome research in neuropsychiatric disorders such as MDD has recently attracted attention. Indeed, the gut‐brain axis could influence the course of MDD through metabolites
Nazanin Zahra Keshvari, Sara Asl Motaleb Nejad Sarkhab, Tara Shahmoradi, Mohammad Pourashory, Arash Esmaeili, Kiarash Saleki, Nima Rezaei   +6 more
wiley   +1 more source