Results 81 to 90 of about 3,281,166 (203)

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: Role in excitotoxicity

Neurobiology of Disease, 2009
Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to ...
Xavier Xifró, Albert Giralt, Ana Saavedra, Juan M. García-Martínez, Miguel Díaz-Hernández, José J. Lucas, Jordi Alberch, Esther Pérez-Navarro   +7 more
doaj   +1 more source

Bivariate Pearson product-moment correlation coefficients between quinolinic acid concentrations and Hamilton Depression Rating Scale (HAMD-17) scores before, during and after IFN-α therapy.

, 2015
Bivariate Pearson product-moment correlation coefficients between quinolinic acid concentrations and Hamilton Depression Rating Scale (HAMD-17) scores before, during and after IFN-α therapy.
Andreas Meinitzer (412847), Robert J. Breitenecker (795546), Rudolf Stauber (795548), Omid Amouzadeh-Ghadikolai (795547), Andreas Baranyi (795545), Hans-Bernd Rothenhäusler (795549)   +5 more
core   +1 more source

Estudo fitoquímico, toxicológico e dos efeitos neuroprotetor e tipo antidepressivo do extrato aquoso de Aloysia gratissima (Gill et Hook) Troncoso (erva santa) [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2011Aloysia gratissima é uma planta utilizada para tratar sintomas de doenças relacionadas principalmente
Zeni, Ana Lúcia Bertarello
core  

Serum Kynurenine Pathway Metabolites as Candidate Diagnostic Biomarkers for Pituitary Adenoma: A Case–Control Study

Medicina
Background and Objectives: Pituitary adenomas are common intracranial tumors lacking specific non-invasive biomarkers. This study aimed to determine whether key metabolites and enzymes of the kynurenine pathway—including indoleamine 2,3-dioxygenase (IDO),
Nur Düzen Oflas, Halil İbrahim Akbay, Murat Alay, Mehmet Erdem   +3 more
doaj   +1 more source

Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats

Neural Plasticity, 2016
Tryptophan is an essential dietary amino acid that is necessary for protein synthesis, but also serves as the precursor for serotonin. However, in addition to these biological functions, tryptophan also serves as a precursor for the kynurenine pathway ...
Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill   +2 more
doaj   +1 more source

Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?

Journal of Translational Medicine, 2018
Background Immune checkpoint inhibitors have revolutionized the treatment paradigm of highly lethal malignancies like advanced non-small cell lung cancer (NSCLC), demonstrating long-term tumour control and extended patient survival.
Andrea Botticelli, Bruna Cerbelli, Luana Lionetto, Ilaria Zizzari, Massimiliano Salati, Annalinda Pisano, Mazzuca Federica, Maurizio Simmaco, Marianna Nuti, Paolo Marchetti   +9 more
doaj   +1 more source

Quantitative assessment of quinolinic acid-induced striatal toxicity in rats using radioligand binding assays.

, 1994
To validate specific, sensitive and quantitative markers of the rat model of Huntington's disease produced by the intrastriatal injection of quinolinic acid, we used striatal homogenate binding assays for [3H]MK-801-labelled N-methyl-D-aspartate ...
Levivier, M., Przedborski, S., Togasaki, D.M., Maloteaux, J.M., Brotchi, J., Holemans, S.   +5 more
core   +1 more source

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in ...
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins   +17 more
doaj   +1 more source

Chronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degeneration

, 1993
The excitotoxic hypothesis of Huntington's disease pathogenesis suggests that selective striatal neuronal loss results from excessive activation of striatal excitatory amino acid receptors.
Albin, Roger L., Becker, Jill B., Bazzett, Terence J., Kaatz, Kevin W., R.L. Albin, T.J. Bazzett, J.B. Becker, K.W. Kaatz   +7 more
core   +1 more source

Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain

, 2008
PK11195, a selective PBR ligand, has been reported to exert a protective effect against the neuronal damage induced by the intrastriatal infusion of quinolinic acid, an excitatory amino acid.
Gee, Tony, Amitani, Misato, Inoue, Osamu, Ohashi, Akihiro, Hatazawa, Jun, Osamu Inoue, Jun Hatazawa, Akihiro Ohashi, Antony Gee, Misato Amitani   +9 more
core   +1 more source