Results 101 to 110 of about 3,281,166 (203)

Theoretical Studies of the Quinolinic Acid to Nicotinic Acid Mononucleotide Transformation

, 2008
Quinolinate phosphoribosyl transferase (QPRTase) is an essential enzyme that catalyzes the transformation of quinolinic acid (QA) to nicotinic acid mononucleotide (NAMN), a key step on the de novo pathway for nicotinamide adenine dinucleotide (NAD ...
Jeehiun K. Lee (1575025), Aleksandr Rozenberg (2017093), Jeehiun K. Lee, Aleksandr Rozenberg   +3 more
core   +1 more source

Characterization of CSF tryptophan metabolites in South African children with tuberculous meningitis

International Journal of Infectious Diseases
Objectives: Tuberculous meningitis (TBM), a severe form of tuberculosis, remains difficult to diagnose and is fatal if left untreated. Children are particularly vulnerable to the disease due to their immature immune systems.
Ontefetse Neo Plaatjie, A. Marceline Tutu van Furth, Regan Solomons, Martijn van der Kuip, Shayne Mason   +4 more
doaj   +1 more source

Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models. [PDF]

J Clin Invest, 2023
Ge X, Zheng M, Hu M, Fang X, Geng D, Liu S, Wang L, Zhang J, Guan L, Zheng P, Xie Y, Pan W, Zhou M, Zhou L, Tang R, Zheng K, Yu Y, Huang XF.   +17 more
europepmc   +1 more source

Quinolinic Acid [PDF]

, 2020
openaire   +1 more source

Neuroprotective effect of MK-801 against intra-striatal quinolinic acid induced behavioral, oxidative stress and cellular alterations in rats

, 2009
880-892 Huntington’s Disease (HD) is a common neurodegenerative disorder characterized by motor disturbances, subcortical dementia and psychiatric disturbances.
Kumar, Puneet, Kalonia, Harikesh, Nehru, Bimla, Kumar, Anil   +3 more
core  

Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

, 1998
Background: Mycobacterium tuberculosis is the single most deadly human pathogen and is responsible for nearly three million deaths every year. Recent elucidation of the mode of action of isoniazid, a frontline antimycobacterial drug, suggests that NAD ...
Grubmeyer, Charles, Sharma, Vivek, Sacchettini, James C   +2 more
core   +1 more source

Synthesis of the neurotoxin quinolinic acid in apoptotic tissue from Suberites domuncula: Cell biological, molecular biological, and chemical analyses

, 2002
Sessile marine animals, such as sponges, are prone to infection by prokaryotic as well as by eukaryotic attacking organisms. Using the sponge Suberites domuncula we document for the first time that in its apoptotic tissue a toxic compound is produced ...
Steffen Renate, De Rosa Salvatore, Perovic Sanja, Müller Isabel M, Sudek Sebastian, De Caro Salvatore, Schröder Heinz Christoph, Müller Werner E G, Salvatore Caro, Werner E.G. M�ller, Sanja Perovic, Isabel M. M�ller, Heinz-Christoph Schr�der, Sebastian Sudek, Salvatore Rosa, Renate Steffen   +15 more
core   +1 more source

Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process. [PDF]

Biol Direct, 2023
Dongol A, Chen X, Zheng P, Seyhan ZB, Huang XF.   +4 more
europepmc   +1 more source

Original paper EFFECTS OF VARIOUS NITRIC OXIDE SYNTHASE INHIBITORS ON QUINOLINIC ACID-INDUCED NEURONAL INJURY IN RATS

, 2014
Summary: The aetiology of neuronal death in neurodegenerative diseases, including Huntington’s disease, is still unknown. There could be a complex interplay among altered energy metabolism, excitotoxicity and oxidative stress.
Marina D. Jovanovi, Ivana D. Vasiljevi, Rosa Mihajlovi, Mirjana \uki Milica Ninkovi   +3 more
core  

Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. [PDF]

J Clin Invest, 2023
Watne LO, Pollmann CT, Neerland BE, Quist-Paulsen E, Halaas NB, Idland AV, Hassel B, Hassel B, Henjum K, Knapskog AB, Frihagen F, Raeder J, Godø A, Ueland PM, McCann A, Figved W, Selbæk G, Zetterberg H, Fang EF, Myrstad M, Giil LM.   +20 more
europepmc   +1 more source