Results 101 to 110 of about 2,516,709 (214)

Estudo do Inibidor da 3-Hidróxi-3-Metilglutaril- Coenzima A Redutase (Atorvastatina) na Transmissão e Toxicidade Glutamatérgica [PDF]

, 2008
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.O glutamato é o principal neurotransmissor excitatório no Sistema Nervoso Central (SNC) de mamíferos participando da comunicação celular e diversas outras ...
Stroeh, Ellen
core  

The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.

PLoS ONE, 2009
Some of the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly the excitotoxin quinolinic acid (QA), are likely to play a role in the pathogenesis of Alzheimer's disease (AD).
Abdur Rahman, Kaka Ting, Karen M Cullen, Nady Braidy, Bruce J Brew, Gilles J Guillemin   +5 more
doaj   +1 more source

Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain

, 2008
PK11195, a selective PBR ligand, has been reported to exert a protective effect against the neuronal damage induced by the intrastriatal infusion of quinolinic acid, an excitatory amino acid.
Gee, Tony, Amitani, Misato, Inoue, Osamu, Ohashi, Akihiro, Hatazawa, Jun   +4 more
core   +1 more source

QUINOLINIC ACID METABOLISM

Journal of Biological Chemistry, 1949
L.M. Henderson, G.B. Ramasarma
  +5 more sources

Beta-trace Protein as a new non-invasive immunological Marker for Quinolinic Acid-induced impaired Blood-Brain Barrier Integrity

, 2017
Quinolinic acid, a macrophage/microglia-derived excitotoxin fulfills a plethora of functions such as neurotoxin, gliotoxin, and proinflammatory mediator, and it alters the integrity and cohesion of the blood-brain barrier in several pathophysiological ...
Dirk von Lewinski, Christoph Robier, Hans-Bernd Rothenhäusler, Omid Amouzadeh-Ghadikolai, Tatjana Stojakovic, Andreas Baranyi, Robert J. Breitenecker, Andreas Meinitzer, Winfried März, Harald Mangge   +9 more
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Correction: Specific Reactions of Different Striatal Neuron Types in Morphology Induced by Quinolinic Acid in Rats

, 2014
Correction: Specific Reactions of Different Striatal Neuron Types in Morphology Induced by Quinolinic Acid in ...
PLOS ONE (2189197)
core   +1 more source

Avaliação do potencial efeito protetor do probucol em modelos experimentais da doença de Huntington [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BioquímicaA doença de Huntington (DH) é uma patologia neurodegenerativa, autossômica dominante caracterizada por sintomas ...
Colle, Dirleise
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De novo NAD+ synthesis is ineffective for NAD+ supply in axenically cultured Caenorhabditis elegans

Communications Biology
To secure an adequate nicotinamide adenine dinucleotide (NAD+) supply for survival, organisms typically rely on two complementary mechanisms: the de novo synthesis pathway and the salvage pathway.
Shihao Zhu, Runshuai Zhang, Luxia Yao, Zhirong Lin, Yanjie Li, Siyuan Li, Lianfeng Wu   +6 more
doaj   +1 more source

Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models. [PDF]

J Clin Invest, 2023
Ge X, Zheng M, Hu M, Fang X, Geng D, Liu S, Wang L, Zhang J, Guan L, Zheng P, Xie Y, Pan W, Zhou M, Zhou L, Tang R, Zheng K, Yu Y, Huang XF.   +17 more
europepmc   +1 more source

Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine

, 2019
International audienceMajor depressive disorder is a complex multifactorial condition with a so far poorly characterized underlying pathophysiology. Consequently, the available treatments are far from satisfactory as it is estimated that up to 30% of ...
de Medeiros, Gabriela Ferreira, Abdel-Ahad, Pierre, Langeron, Olivier, van Steenwinckel, Juliette, Verdonk, Franck, Petit, Anne-Cécile, Blatzer, Michael, Launay, Jean-Marie, Maignan, Anna, Gaillard, Raphael, Sharshar, Tarek, de Maricourt, Pierre, Vinckier, Fabien, Callebert, Jacques, Chrétien, Fabrice, Jouvion, Gregory, Danckaert, Anne   +16 more
core   +1 more source