Results 121 to 130 of about 15,449 (218)

Characterization of CSF tryptophan metabolites in South African children with tuberculous meningitis

International Journal of Infectious Diseases
Objectives: Tuberculous meningitis (TBM), a severe form of tuberculosis, remains difficult to diagnose and is fatal if left untreated. Children are particularly vulnerable to the disease due to their immature immune systems.
Ontefetse Neo Plaatjie, A. Marceline Tutu van Furth, Regan Solomons, Martijn van der Kuip, Shayne Mason   +4 more
doaj   +1 more source

C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder. [PDF]

Brain Behav Immun, 2022
Zheng H, Teague TK, Yeh FC, Burrows K, Figueroa-Hall LK, Aupperle RL, Khalsa SS, Paulus MP, Savitz J.   +8 more
europepmc   +1 more source

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum [PDF]

, 2017
The ability to overexpress full-length huntingtin or large fragments represents an important challenge to mimic Huntington's pathology and reproduce all stages of the disease in a time frame compatible with rodent life span.
Aebischer, Patrick, Déglon, Nicole, Perrin, Valérie, Régulier, Etienne, Trottier, Yvon   +4 more
core  

Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer

Clinical and Translational Medicine
Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage non‐small‐cell lung cancer (NSCLC), but it has not consistently yielded durable responses.
Ailing Cao, Yaobin Lin, Shaoxing Guan, Youhao Chen, Wenyu Zhai, Yuheng Zhou, Shoucheng Feng, Yanping Guan, Yiyu Zhang, Min Huang, Xueding Wang, Hao Long   +11 more
doaj   +1 more source

Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats. [PDF]

Molecules, 2022
Kumar Arora M, Ratra A, Asdaq SMB, Alshamrani AA, Alsalman AJ, Kamal M, Tomar R, Sahoo J, Ashok J, Imran M.   +9 more
europepmc   +1 more source

Behavioral activation therapy for depression is associated with a reduction in the concentration of circulating quinolinic acid. [PDF]

Psychol Med, 2022
Savitz J, Ford BN, Yeh HW, Akeman E, Cosgrove K, Clausen AN, Martell C, Kirlic N, Santiago J, Teague TK, Irwin MR, Paulus MP, Aupperle RL.   +12 more
europepmc   +1 more source

Caenorhabditis elegans as a model for studies on quinolinic acid-induced NMDAR-dependent glutamatergic disorders. [PDF]

Brain Res Bull, 2021
Limana da Silveira T, Lopes Machado M, Bicca Obetine Baptista F, Farina Gonçalves D, Duarte Hartmann D, Marafiga Cordeiro L, Franzen da Silva A, Lenz Dalla Corte C, Aschner M, Antunes Soares FA.   +9 more
europepmc   +1 more source

The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin. [PDF]

Pharmaceuticals (Basel), 2022
Bettini E, De Martin S, Mattarei A, Pappagallo M, Stahl SM, Bifari F, Inturrisi CE, Folli F, Traversa S, Manfredi PL.   +9 more
europepmc   +1 more source

Mechanistic Insight into Diosmin-Induced Neuroprotection and Memory Improvement in Intracerebroventricular-Quinolinic Acid Rat Model: Resurrection of Mitochondrial Functions and Antioxidants. [PDF]

Evid Based Complement Alternat Med, 2022
Huang M, Singh N, Kainth R, Khalid M, Kushwah AS, Kumar M.   +5 more
europepmc   +1 more source

Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in systemic lupus erythematosus. [PDF]

Lupus Sci Med, 2021
Anderson EW, Fishbein J, Hong J, Roeser J, Furie RA, Aranow C, Volpe BT, Diamond B, Mackay M.   +8 more
europepmc   +1 more source