Results 111 to 120 of about 816,736 (162)

Inhibition of quinolinate phosphoribosyl transferase by pyridine analogs of quinolinic acid

Biochemical and Biophysical Research Communications, 1988
The enzyme quinolinate phosphoribosyl transferase was purified from ATCC strain 23269. An HPLC method was developed for the analysis of the product of the enzyme reaction, nicotinate mononucleotide. Steady state kinetics in the forward reaction demonstrated a sequential mechanism for the enzyme. In order to gain more information on the mechanism of the
L, Kalikin, K C, Calvo
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A photometric method for the determination of quinolinic acid

Archives of Biochemistry and Biophysics, 1953
Abstract 1. 1. A photometric method is described for the determination of quinolinic acid in trichloroacetic acid extracts of tissue preparations which have metabolized 3-hydroxyanthranilic acid. 2. 2. The method is based on the measurement of the stable yellow color of the ferrous chelate of quinolinic acid.
M, RABINOVITZ, R A, FINEBERG, D M, GREENBERG   +2 more
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Renal gluconeogenesis effects of quinolinic acid

Biochimica et Biophysica Acta (BBA) - General Subjects, 1972
Abstract Quinolinic acid, a metabolic degradation product of tryptophan metabolism and a known inhibitor of hepatic gluconeogenesis in vivo, has been shown in the present studies to inhibit renal gluconeogenesis in vitro. At pH 7.4 quinolinic acid decreased glucose production from glutamine and glutamate by rat renal cortex by more than 50%.
S, Klahr, A C, Schoolwerth
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The quinolinic acid hypothesis in Huntington's chorea

Journal of the Neurological Sciences, 1990
In the central nervous system and particularly in the striatum of patients with Huntington's disease (HD) a dramatic cell loss can be observed. Animal models of HD are based on intrastriatal injection of excitatory amino acids (EAAs). Stimulation of EAA receptors for a prolonged period of time degenerates the cells on which the EAA receptors are ...
R P, Bruyn, J C, Stoof
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma

1991
Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A, Gramsbergen, J B, Speciale, C, Schwarcz, R   +3 more
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Brain quinolinic acid in Alzheimer's dementia

European Archives of Psychiatry and Neurological Sciences, 1989
Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method.
E, Sofic, J, Halket, A, Przyborowska, P, Riederer, H, Beckmann, M, Sandler, K, Jellinger   +6 more
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Quinolinic acid in children with congenital hyperammonemia

Annals of Neurology, 1993
AbstractLevels of the excitotoxin quinolinic acid (QUIN) were measured in the cerebrospinal fluid of infants and children with congenital hyperammonemia. Twofold to tenfold elevations of QUIN were found in 4 neonates in hyperammonemic coma (QUIN range, 250–990 nM; control mean, 110 ± 90 nM; p < 0.005).
M L, Batshaw, M B, Robinson, K, Hyland, S, Djali, M P, Heyes   +4 more
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Brain Quinolinic Acid in Huntington's Disease

Journal of Neurochemistry, 1988
Abstract: Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method.
G P, Reynolds, S J, Pearson, J, Halket, M, Sandler   +3 more
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Quinolinic Acid: A Pathogen in Seizure Disorders?

1986
The evidence for an involvement of QUIN in human seizure disorders is clearly circumstantial. Importantly, QUIN is not a classical neurotransmitter and may thus play only a negligible or no role at all in normal brain function (Foster et al., 1984). We have yet to understand if and how such a possibly inert metabolite may turn into a pathogen.
R, Schwarcz, C, Speciale, E, Okuno, E D, French, C, Köhler   +4 more
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Bromodecarboxylation of Quinoline Salicylic Acids: Increasing the Diversity of Accessible Substituted Quinolines

The Journal of Organic Chemistry, 2009
Quinoline salicylic acids underwent bromodecarboxylation at room temperature upon treatment with N-bromosuccinimide. A wide variety of functional groups was tolerated. Several one-pot transformations were also carried out, allowing the preparation of diverse 4-substituted quinolines.
Kristin, Janz, Neelu, Kaila
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