Results 111 to 120 of about 4,572 (161)

Renal gluconeogenesis effects of quinolinic acid

Biochimica et Biophysica Acta (BBA) - General Subjects, 1972
Abstract Quinolinic acid, a metabolic degradation product of tryptophan metabolism and a known inhibitor of hepatic gluconeogenesis in vivo, has been shown in the present studies to inhibit renal gluconeogenesis in vitro. At pH 7.4 quinolinic acid decreased glucose production from glutamine and glutamate by rat renal cortex by more than 50%.
S, Klahr, A C, Schoolwerth
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma

1991
Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A, Gramsbergen, J B, Speciale, C, Schwarcz, R   +3 more
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The quinolinic acid hypothesis in Huntington's chorea

Journal of the Neurological Sciences, 1990
In the central nervous system and particularly in the striatum of patients with Huntington's disease (HD) a dramatic cell loss can be observed. Animal models of HD are based on intrastriatal injection of excitatory amino acids (EAAs). Stimulation of EAA receptors for a prolonged period of time degenerates the cells on which the EAA receptors are ...
R P, Bruyn, J C, Stoof
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A photometric method for the determination of quinolinic acid

Archives of Biochemistry and Biophysics, 1953
Abstract 1. 1. A photometric method is described for the determination of quinolinic acid in trichloroacetic acid extracts of tissue preparations which have metabolized 3-hydroxyanthranilic acid. 2. 2. The method is based on the measurement of the stable yellow color of the ferrous chelate of quinolinic acid.
M, RABINOVITZ, R A, FINEBERG, D M, GREENBERG   +2 more
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Quinolinic acid in children with congenital hyperammonemia

Annals of Neurology, 1993
AbstractLevels of the excitotoxin quinolinic acid (QUIN) were measured in the cerebrospinal fluid of infants and children with congenital hyperammonemia. Twofold to tenfold elevations of QUIN were found in 4 neonates in hyperammonemic coma (QUIN range, 250–990 nM; control mean, 110 ± 90 nM; p < 0.005).
M L, Batshaw, M B, Robinson, K, Hyland, S, Djali, M P, Heyes   +4 more
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Brain Quinolinic Acid in Huntington's Disease

Journal of Neurochemistry, 1988
Abstract: Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method.
G P, Reynolds, S J, Pearson, J, Halket, M, Sandler   +3 more
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Quinolinic Acid: A Pathogen in Seizure Disorders?

1986
The evidence for an involvement of QUIN in human seizure disorders is clearly circumstantial. Importantly, QUIN is not a classical neurotransmitter and may thus play only a negligible or no role at all in normal brain function (Foster et al., 1984). We have yet to understand if and how such a possibly inert metabolite may turn into a pathogen.
R, Schwarcz, C, Speciale, E, Okuno, E D, French, C, Köhler   +4 more
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QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

2003
We propose that the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly quinolinic acid (QUIN), may play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we demonstrated that after 72 hours amyloid peptide (Abeta) 1-42 induced indoleamine 2,3-dioxygenase (IDO) expression and in a ...
Gilles J, Guillemin, Kieran R, Williams, Danielle G, Smith, George A, Smythe, Juliana, Croitoru-Lamoury, Bruce J, Brew   +5 more
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Bromodecarboxylation of Quinoline Salicylic Acids: Increasing the Diversity of Accessible Substituted Quinolines

The Journal of Organic Chemistry, 2009
Quinoline salicylic acids underwent bromodecarboxylation at room temperature upon treatment with N-bromosuccinimide. A wide variety of functional groups was tolerated. Several one-pot transformations were also carried out, allowing the preparation of diverse 4-substituted quinolines.
Kristin, Janz, Neelu, Kaila
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Quinolinic acid-immunoreactivity in the naïve mouse brain

Journal of Chemical Neuroanatomy, 2016
Quinolinic acid (QUIN) has been suggested to be involved in infections, inflammatory neurological disorders and in the development of psychiatric disorders. In this view, several studies have been performed to investigate QUIN localization in the brain and its neurotoxic effects.
Lopez, Yara Pujol, Kenis, Gunter, Rutten, Bart P. F., Myint, Aye M., Steinbusch, Harry W. M., van den Hove, Daniel L. A.   +5 more
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