Results 101 to 110 of about 4,572 (161)

Modern Analytical Techniques in Epilepsy Research. [PDF]

Int J Mol Sci
Idzikowska K, Gątarek P, Kałużna-Czaplińska J.   +2 more
europepmc   +1 more source

Tryptophan-Derived Metabolites and Glutamate Dynamics in Fatal Insulin Poisoning: Mendelian Randomization of Human Cohorts and Experimental Validation in Rat Models. [PDF]

Int J Mol Sci
Yuan Y, Liu Y, Wang S, Zhang J, Gao X, Li Y, Yu Z, Zhou Y.   +7 more
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Higher Plasma Kynurenine to Tryptophan Correlates with an Increased Incidence of Mild Cognitive Impairment in Treated Metabolic Syndrome Patients. [PDF]

ACS Omega
Jariyasopit N, Phochmak T, Manocheewa S, Wanichthanarak K, Limjiasahapong S, Kleebkomut N, Sirivatanauksorn Y, Sirivatanauksorn V, Phrommintikul A, Chattipakorn N, Chattipakorn S, Khoomrung S.   +11 more
europepmc   +1 more source

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A radioenzymatic assay for quinolinic acid

Analytical Biochemistry, 1986
A new and rapid method for the determination of the excitotoxic tryptophan metabolite quinolinic acid is based on its enzymatic conversion to nicotinic acid mononucleotide and, in a second step utilizing [3H]ATP, further to [3H] deamido-NAD. Specificity of the assay is assured by using a highly purified preparation of the specific quinolinic acid ...
A C, Foster, E, Okuno, D S, Brougher, R, Schwarcz   +3 more
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Quinoline-4-carboxylic Acid

Acta Crystallographica Section C Crystal Structure Communications, 1998
The title acid, C10H7NO2, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. There is a single hydrogen bond. O-H...N, with a donor-acceptor distance of 2.596 (1) A. The carboxylic H atom is ordered. The dihedral angle between the best-fit quinoline core plane and the carboxyl plane is 45.9 (1) degrees ...
Amonette, Allison J., Gerkin, Roger E.
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Quinolinic Acid and Kynurenic Acid in the Mammalian Brain

1991
Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
R, Schwarcz, F, Du
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Inhibition of quinolinate phosphoribosyl transferase by pyridine analogs of quinolinic acid

Biochemical and Biophysical Research Communications, 1988
The enzyme quinolinate phosphoribosyl transferase was purified from ATCC strain 23269. An HPLC method was developed for the analysis of the product of the enzyme reaction, nicotinate mononucleotide. Steady state kinetics in the forward reaction demonstrated a sequential mechanism for the enzyme. In order to gain more information on the mechanism of the
L, Kalikin, K C, Calvo
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Quinolinic Acid Phosphoribosyltransferase in Rat Brain

Journal of Neurochemistry, 1985
Abstract: Because of the possible participation of quinolinic acid in brain function and/or dysfunction, the characteristics of its catabolic enzyme, quinolinic acid phosphoribosyltransferase (QPRTase; EC 2.4.2.19), were examined in rat brain tissue. For this purpose, a sensitive radiochemical assay method, based on the conversion of quinolinic acid ...
A C, Foster, W C, Zinkand, R, Schwarcz
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Brain quinolinic acid in Alzheimer's dementia

European Archives of Psychiatry and Neurological Sciences, 1989
Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method.
E, Sofic, J, Halket, A, Przyborowska, P, Riederer, H, Beckmann, M, Sandler, K, Jellinger   +6 more
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