Results 81 to 90 of about 880,028 (202)

Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes [PDF]

, 2005
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Newcombe, J, Kalina, P, Kepplinger, B, Baran, H, Ferraz-Leite, H, Kainz, A   +5 more
core  

Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid

, 2016
Quinolinic acid (QA) is a common intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+) and its derivatives in all organisms that synthesize the molecule de novo.
Tyler L. Grove (1322103), Martin I. McLaughlin (2812924), Neela H. Yennawar (1430569), Squire J. Booker (1322109), Alexey Silakov (1322100), Olga A. Esakova (2812921), Allison H. Saunders (2812927)   +6 more
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Bivariate Pearson product-moment correlation coefficients between quinolinic acid concentrations and Hamilton Depression Rating Scale (HAMD-17) scores before, during and after IFN-α therapy.

, 2015
Bivariate Pearson product-moment correlation coefficients between quinolinic acid concentrations and Hamilton Depression Rating Scale (HAMD-17) scores before, during and after IFN-α therapy.
Andreas Meinitzer (412847), Robert J. Breitenecker (795546), Rudolf Stauber (795548), Omid Amouzadeh-Ghadikolai (795547), Andreas Baranyi (795545), Hans-Bernd Rothenhäusler (795549)   +5 more
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The mechanism of quinolinic acid-induced neurite lesions: The role of NR2B, ROS and autophagy

, 2022
Increased quinolinic acid (QA) has been suggested in various mental disease pathology. Excessive QA is shown to overactivate N-Methyl-D-aspartic acid (NMDA) receptor subunit 2B (NR2B) receptors and is deleterious to the neurons; however, the exact ...
Yuanyi Xie (20166906)
core   +1 more source

Extracellular levels of quinolinic acid are moderately increased in rat neostriatum following severe insulin-induced hypoglycaemia

, 1990
Extracellular concentrations of the brain metabolite quinolinic acid, an endogenous excitotoxin, were monitored by microdialysis in rat neostriatum and hippocampus/cortex during and following a 30-min period of insulin-induced hypoglycaemia.
Wieloch, T., Westerberg, E., Magnusson, K., Schwarcz, R., Speciale, C., Ungerstedt, U., Ungerstedt, U.,, Wieloch, T.,, Magnusson, K.,, Speciale, C.,, Westerberg, E.,, Schwarcz, R.,, Lund University.   +12 more
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Variations in Quinolinic Acid Levels in Tuberculosis Patients with Diabetes Comorbidity: A Pilot Prospective Cohort Study

Infection and Drug Resistance
Min Yang,1– 3,* Wenfei Wang,3,* Peize Zhang,4 Guizhen Liu,5 Hailin Lu,6 Mingjie He,5 Guofang Deng,2,3 Xiaoyou Chen1,7 1Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical
Yang M, Wang W, Zhang P, Liu G, Lu H, He M, Deng G, Chen X   +7 more
doaj  

Effects of excitotoxic amino acids on pituitary hormone secretion in the rat

, 1983
The acute effects of administration of 4 excitatory amino acids (n-methyl- dl-aspartic acid (NMA), kainic acid (KA), ibotenic acid (IA) and quinolinic acid (QA)) on the serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH),
Mason, George A, Memeroff, Charles B, Bissette, Garth   +2 more
core   +1 more source

Quinolinic acid lesion induces changes in rat striatal glutathione metabolism

, 2000
Although the involvement of oxidative mechanisms in the cytotoxicity of excitatory amino acids has been well documented, it is not known whether the intrastriatal injection of quinolinic acid (QA) induces changes in glutathione (GSH) metabolism.
Reyniel Cruz-Aguado, Inna Antúnez, Liliana Francis-Turner, Carmen M Dı́az   +3 more
core   +1 more source

Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum

, 1995
Injection of quinolinic acid in the rat striatum mimics neurochemical changes observed in Huntington's disease. We previously demonstrated that intrastriatal transplantation of fetal striatum or gelfoam protects against toxicity induced by a subsequent ...
Przedborski, S., Gash, Don Marshall, Levivier, Marc, Levivier, M., Gash, D.M., D.M. Gash, M. Levivier, S. Przedborski   +7 more
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Crystal structure of N-[2-(cyclohexylsulfanyl)ethyl]quinolinic acid imide

, 2017
The title compound, C15H18N2O2S {systematic name: 6-[2-(cyclohexylsulfanyl)ethyl]-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione}, was obtained from the reaction of pyridine-2,3-dicarboxylic anhydride (synonym: quinolinic anhydride) with 2-(cyclohexylsulfanyl ...
Tae Ho Kim, Cheol Joo Moon, Hyunjin Park, Myong Yong Choi   +3 more
core   +1 more source