Results 71 to 80 of about 816,736 (162)

Major Depressive Disorder Signatures: A Review of Artificial Intelligence (AI)‐Powered Insights Into Gut Dysbiosis

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Major Depressive Disorder (MDD) is a highly common neuropsychiatric disorder globally. A variety of factors contribute to the neuropathology of MDD. Microbiome research in neuropsychiatric disorders such as MDD has recently attracted attention. Indeed, the gut‐brain axis could influence the course of MDD through metabolites
Nazanin Zahra Keshvari, Sara Asl Motaleb Nejad Sarkhab, Tara Shahmoradi, Mohammad Pourashory, Arash Esmaeili, Kiarash Saleki, Nima Rezaei   +6 more
wiley   +1 more source

Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women [PDF]

, 2001
We tested whether trans fatty acids and saturated fatty acids had different effects on flow-mediated vasodilation (FMD), a risk marker of coronary heart disease (CHD). Consumption of trans fatty acids is related to increased risk of CHD, probably through
Roos, N.M., de, Katan, M.B., Bots, M.L.
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Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease

Signal Transduction and Targeted Therapy
Alzheimer’s disease (AD) is a major cause of dementia and a prevalent age-related neurodegenerative disorder characterized by progressive cognitive impairment and memory loss.
Seung Jae Hyeon, Seung Chan Kim, Jiyeon Chu, Yeonseo Kim, Chaebin Kim, Uiyeol Park, Zahid Tufail, Phuong Thi Thanh Nguyen, Ahreum Eom, Sojung Kim, Yeyun Kim, Eunkyung Lee, Suhyun Kim, Seung Eun Lee, Jiwan Woo, Jin-A Lee, Kyung Eun Lee, Thor D. Stein, Hyunbeom Lee, Junghee Lee, Hoon Ryu   +20 more
doaj   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source

Serum neurotransmitter analysis of motor and non-motor symptoms in Parkinson’s patients

Frontiers in Aging Neuroscience
Clinical symptoms of Parkinson’s disease (PD) are classified into motor and non-motor symptoms. Mental disorders, especially depression, are one of the major non-motor manifestations of PD. However, the underlying mechanisms remain poorly understood.
Yichun Fan, Yichun Fan, Wenping Yang, Weilan Wu, Weilan Wu, Xinjing Wang, Yuxin Lin, Yuxin Lin, Linlin Wu, Jun Wang, Jun Wang, Fei Huan, Fei Huan, Haixia Ding, Rong Gao, Rong Gao   +15 more
doaj   +1 more source

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source

Avaliação do potencial efeito protetor do probucol em modelos experimentais da doença de Huntington [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BioquímicaA doença de Huntington (DH) é uma patologia neurodegenerativa, autossômica dominante caracterizada por sintomas ...
Colle, Dirleise
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Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source

Estudo do pré-condicionamento com n-metil-d-aspartato (NMDA) em convulsões induzidas por ácido quinolínico em camundongos [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.O objetivo deste estudo foi avaliar o tipo de morte celular no hipocampo e córtex cerebral induzida pela ...
Vandresen Filho, Samuel
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