Results 91 to 100 of about 816,736 (162)

Role of gut microbiota dysbiosis in podophyllotoxin-induced neurotoxicity in zebrafish: linking purine metabolism to synaptic dysfunction

BMC Microbiology
Podophyllotoxin (PPT) is a naturally occurring plant-derived insecticide, yet its potent cytotoxicity raises concerns regarding potential neurobehavioral toxicity in non-target organisms. However, the underlying mechanisms remain largely unclear.
Yi Ru, Ying Yu, Chuanxin Liu, Yunge Liu, Dongxia Liu, Ruyan Chen, Xiaowan Chen, Xiaoyang Bai, Tao Jiang, Jiajia Duan   +9 more
doaj   +1 more source

Neuroprotective effect of MK-801 against intra-striatal quinolinic acid induced behavioral, oxidative stress and cellular alterations in rats

, 2009
880-892 Huntington’s Disease (HD) is a common neurodegenerative disorder characterized by motor disturbances, subcortical dementia and psychiatric disturbances.
Kumar, Puneet, Kalonia, Harikesh, Nehru, Bimla, Kumar, Anil   +3 more
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Variations in Quinolinic Acid Levels in Tuberculosis Patients with Diabetes Comorbidity: A Pilot Prospective Cohort Study

Infection and Drug Resistance
Min Yang,1– 3,* Wenfei Wang,3,* Peize Zhang,4 Guizhen Liu,5 Hailin Lu,6 Mingjie He,5 Guofang Deng,2,3 Xiaoyou Chen1,7 1Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical
Yang M, Wang W, Zhang P, Liu G, Lu H, He M, Deng G, Chen X   +7 more
doaj  

Extracellular levels of quinolinic acid are moderately increased in rat neostriatum following severe insulin-induced hypoglycaemia

, 1990
Extracellular concentrations of the brain metabolite quinolinic acid, an endogenous excitotoxin, were monitored by microdialysis in rat neostriatum and hippocampus/cortex during and following a 30-min period of insulin-induced hypoglycaemia.
Wieloch, T., Westerberg, E., Magnusson, K., Schwarcz, R., Speciale, C., Ungerstedt, U.   +5 more
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Chronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degeneration

, 1993
The excitotoxic hypothesis of Huntington's disease pathogenesis suggests that selective striatal neuronal loss results from excessive activation of striatal excitatory amino acid receptors.
Albin, Roger L., Becker, Jill B., Bazzett, Terence J., Kaatz, Kevin W.   +3 more
core   +1 more source

Quantitative assessment of quinolinic acid-induced striatal toxicity in rats using radioligand binding assays.

, 1994
To validate specific, sensitive and quantitative markers of the rat model of Huntington's disease produced by the intrastriatal injection of quinolinic acid, we used striatal homogenate binding assays for [3H]MK-801-labelled N-methyl-D-aspartate ...
Levivier, M., Przedborski, S., Togasaki, D.M., Maloteaux, J.M., Brotchi, J., Holemans, S.   +5 more
core   +1 more source

The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism

, 1992
Eicosanoids, in particular prostaglandin E2 (PGE2), are potent inhibitors of a number of immune responses, including lymphocyte proliferation. We have previously shown that fatty acids, especially polyunsaturated fatty acids (PUFA), inhibit mitogen ...
Calder, P.C., Newsholme, E.A., Bevan, S.J.   +2 more
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Hesperidin Plays Neuroprotective Effects Against Quinolinic Acid in Human SH-SY5Y Cells: Focusing on ROS Levels and Cell Cycle Arrest [PDF]

Background and objectives: In some neurodegenerative diseases, an aberrant accumulation of quinolinic acid is frequently associated with the loss of nerve cells and a condition known as neuritis.
Emad Azimi, Mehdi Rostami, Mohammad Soukhtanloo*, Elaheh Gheybi, Farzaneh Abbasinezhad-Moud   +4 more
core   +2 more sources

Condensation of Phenols and Aromatic Amines with Quinolinic and Nicotinic Acids to Form Dyes Analogous to the Phthaleins [PDF]

, 1934
The author was desirous of investigating the properties of "quinolineins" as compared with those of corresponding phthaleins. As there was no quinolinic acid available in the laboratory, an attempt was made to prepare it.
Berger, Julius
core   +1 more source

Anacardic Acids and Ferric Ion Chelation [PDF]

, 2007
6-Pentadeca(e)nylsalicylic acids isolated from the cashew Anacardium occidentale L. (Anacardiaceae), commonly known as anacardic acids, inhibited the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, type 1) competitively ...
Hayashi, Akio, Tsujimoto, Kazuo, Joung Ha, Tae, Kubo, Isao   +3 more
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