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Oligodendrocyte killing by quinolinic acid in vitro

Brain Research, 2001
Quinolinic acid, which is produced by macrophages and microglia, can kill neurons in vivo and in vitro. To test whether quinolinic acid is toxic to oligodendrocytes, glial cells cultured from the brains of 2-day-old rats were incubated with quinolinic acid at concentrations known to kill neurons.
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Quinolinic Acid and Active Oxygens

1996
Quinolinic acid (QA, pyridine-2,3-dicarboxylic acid) is an intermediate of the kynurenine pathway in the tryptophan metabolism, which has been detected in the central nervous system (Gal and Sherman, 1978; Speciale and Schwarcz, 1993), and behaves as an excitotoxin (Lapin, 1978; Schwarcz et al., 1983).
K. Goda   +4 more
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Quinolinic Acid and Inflammation

Annals of the New York Academy of Sciences, 1993
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Derivatives Of Quinoline-3-Carboxylic Acid And Benzo(f)Quinoline-2-Carboxylic Acid.

1949
PhD ; Pharmacology ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/182998/2/0002401 ...
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Quinolinic Acid

2010
J.L. McBride   +2 more
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Quinolinic acid and kynurenic acid

Trends in Pharmacological Sciences, 1984
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Quinolinic acid and the kynurenines

Trends in Pharmacological Sciences, 1989
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