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Interplay of gut microbiota, immune cells and natural products in reshaping cancer immunotherapy. [PDF]

open access: yesFront Microbiol
Wu X   +12 more
europepmc   +1 more source
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A Radioenzymatic Assay for Quinolinic Acid

Analytical Biochemistry, 1986
A new and rapid method for the determination of the excitotoxic tryptophan metabolite quinolinic acid is based on its enzymatic conversion to nicotinic acid mononucleotide and, in a second step utilizing [3H]ATP, further to [3H] deamido-NAD. Specificity of the assay is assured by using a highly purified preparation of the specific quinolinic acid ...
Robert Schwarcz, Etsuo Okuno, A C Foster
exaly   +3 more sources

Quinolinic Acid Phosphoribosyltransferase in Rat Brain

Journal of Neurochemistry, 1985
Abstract: Because of the possible participation of quinolinic acid in brain function and/or dysfunction, the characteristics of its catabolic enzyme, quinolinic acid phosphoribosyltransferase (QPRTase; EC 2.4.2.19), were examined in rat brain tissue. For this purpose, a sensitive radiochemical assay method, based on the conversion of quinolinic acid ...
Robert Schwarcz   +2 more
exaly   +3 more sources

The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases [PDF]

open access: yesBiomolecules, 2022
Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
Jan Alexander   +2 more
exaly   +2 more sources

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