Emerging links between gut dysbiosis, aryl hydrocarbon receptor activation, and Parkinson's disease. [PDF]
Aziz NF, Kortagere S.
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Integrated transcriptomic and metabolomic analyses reveal the regulatory network underlying NtGSTU10-mediated nicotine synthesis and transport in tobacco. [PDF]
Zhou Y +8 more
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Gut microbiota metabolites in inflammatory bowel disease: advances in mechanistic insights. [PDF]
Liang Y, Zhou Y, Luo P, Lin J.
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Interplay of gut microbiota, immune cells and natural products in reshaping cancer immunotherapy. [PDF]
Wu X +12 more
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Amino Acid-Fatty Acid Profile as a Novel Predictive Method in the Assessment of Diagnosis and Treatment Efficacy of Anxiety-Related Disorders and Mood Disorders. [PDF]
Kowalczyk M +7 more
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<i>GRIA3</i>: proposal for a neuroimmune role linking infection, stress, chronic disorders and the activity of kynurenic acid. [PDF]
Stone TW, Clanchy FIL, Williams RO.
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A Radioenzymatic Assay for Quinolinic Acid
Analytical Biochemistry, 1986A new and rapid method for the determination of the excitotoxic tryptophan metabolite quinolinic acid is based on its enzymatic conversion to nicotinic acid mononucleotide and, in a second step utilizing [3H]ATP, further to [3H] deamido-NAD. Specificity of the assay is assured by using a highly purified preparation of the specific quinolinic acid ...
Robert Schwarcz, Etsuo Okuno, A C Foster
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Quinolinic Acid Phosphoribosyltransferase in Rat Brain
Journal of Neurochemistry, 1985Abstract: Because of the possible participation of quinolinic acid in brain function and/or dysfunction, the characteristics of its catabolic enzyme, quinolinic acid phosphoribosyltransferase (QPRTase; EC 2.4.2.19), were examined in rat brain tissue. For this purpose, a sensitive radiochemical assay method, based on the conversion of quinolinic acid ...
Robert Schwarcz +2 more
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The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases [PDF]
Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
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