Results 161 to 170 of about 880,028 (202)
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The quinolinic acid hypothesis in Huntington's chorea
Journal of the Neurological Sciences, 1990In the central nervous system and particularly in the striatum of patients with Huntington's disease (HD) a dramatic cell loss can be observed. Animal models of HD are based on intrastriatal injection of excitatory amino acids (EAAs). Stimulation of EAA receptors for a prolonged period of time degenerates the cells on which the EAA receptors are ...
R P, Bruyn, J C, Stoof
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Quinolinic Acid: A Pathogen in Seizure Disorders?
1986The evidence for an involvement of QUIN in human seizure disorders is clearly circumstantial. Importantly, QUIN is not a classical neurotransmitter and may thus play only a negligible or no role at all in normal brain function (Foster et al., 1984). We have yet to understand if and how such a possibly inert metabolite may turn into a pathogen.
R, Schwarcz +4 more
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The Journal of Organic Chemistry, 2009
Quinoline salicylic acids underwent bromodecarboxylation at room temperature upon treatment with N-bromosuccinimide. A wide variety of functional groups was tolerated. Several one-pot transformations were also carried out, allowing the preparation of diverse 4-substituted quinolines.
Kristin, Janz, Neelu, Kaila
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Quinoline salicylic acids underwent bromodecarboxylation at room temperature upon treatment with N-bromosuccinimide. A wide variety of functional groups was tolerated. Several one-pot transformations were also carried out, allowing the preparation of diverse 4-substituted quinolines.
Kristin, Janz, Neelu, Kaila
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QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
2003We propose that the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly quinolinic acid (QUIN), may play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we demonstrated that after 72 hours amyloid peptide (Abeta) 1-42 induced indoleamine 2,3-dioxygenase (IDO) expression and in a ...
Gilles J, Guillemin +5 more
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Oligodendrocyte killing by quinolinic acid in vitro
Brain Research, 2001Quinolinic acid, which is produced by macrophages and microglia, can kill neurons in vivo and in vitro. To test whether quinolinic acid is toxic to oligodendrocytes, glial cells cultured from the brains of 2-day-old rats were incubated with quinolinic acid at concentrations known to kill neurons.
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Quinolinic acid-immunoreactivity in the naïve mouse brain
Journal of Chemical Neuroanatomy, 2016Quinolinic acid (QUIN) has been suggested to be involved in infections, inflammatory neurological disorders and in the development of psychiatric disorders. In this view, several studies have been performed to investigate QUIN localization in the brain and its neurotoxic effects.
Lopez, Yara Pujol +5 more
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Quinolinic Acid and Active Oxygens
1996Quinolinic acid (QA, pyridine-2,3-dicarboxylic acid) is an intermediate of the kynurenine pathway in the tryptophan metabolism, which has been detected in the central nervous system (Gal and Sherman, 1978; Speciale and Schwarcz, 1993), and behaves as an excitotoxin (Lapin, 1978; Schwarcz et al., 1983).
K. Goda +4 more
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Quinolinic Acid and Inflammation
Annals of the New York Academy of Sciences, 1993openaire +2 more sources
Derivatives Of Quinoline-3-Carboxylic Acid And Benzo(f)Quinoline-2-Carboxylic Acid.
1949PhD ; Pharmacology ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/182998/2/0002401 ...
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