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Quinolinic Acid Accumulation During Neuroinflammation
Annals of the New York Academy of Sciences, 2001Abstract:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist ofN‐methyl‐d‐aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation.
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Oligodendrocyte killing by quinolinic acid in vitro
Brain Research, 2001Quinolinic acid, which is produced by macrophages and microglia, can kill neurons in vivo and in vitro. To test whether quinolinic acid is toxic to oligodendrocytes, glial cells cultured from the brains of 2-day-old rats were incubated with quinolinic acid at concentrations known to kill neurons.
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Quinolinic Acid and Inflammation
Annals of the New York Academy of Sciences, 1993openaire +2 more sources