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Melatonin Reduces Oxidative Neurotoxicity Due to Quinolinic Acid:: In Vitro and in Vivo Findings
Neuropharmacology, 2000 The in vivo and in vitro effects of melatonin on quinolinic acid-induced oxidative damage in rat brain were determined. The concentrations of malonaldehyde and 4-hydroxyalkenals were assayed as an index of oxidatively damaged lipid.
Russel J Reiter +2 more
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Acta Crystallographica Section C Crystal Structure Communications, 1998
The title acid, C10H7NO2, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. There is a single hydrogen bond. O-H...N, with a donor-acceptor distance of 2.596 (1) A. The carboxylic H atom is ordered. The dihedral angle between the best-fit quinoline core plane and the carboxyl plane is 45.9 (1) degrees ...
Amonette, Allison J., Gerkin, Roger E.
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The title acid, C10H7NO2, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. There is a single hydrogen bond. O-H...N, with a donor-acceptor distance of 2.596 (1) A. The carboxylic H atom is ordered. The dihedral angle between the best-fit quinoline core plane and the carboxyl plane is 45.9 (1) degrees ...
Amonette, Allison J., Gerkin, Roger E.
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Quinolinic Acid and Kynurenic Acid in the Mammalian Brain
1991Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
R, Schwarcz, F, Du
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Inhibition of quinolinate phosphoribosyl transferase by pyridine analogs of quinolinic acid
Biochemical and Biophysical Research Communications, 1988The enzyme quinolinate phosphoribosyl transferase was purified from ATCC strain 23269. An HPLC method was developed for the analysis of the product of the enzyme reaction, nicotinate mononucleotide. Steady state kinetics in the forward reaction demonstrated a sequential mechanism for the enzyme. In order to gain more information on the mechanism of the
L, Kalikin, K C, Calvo
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Brain quinolinic acid in Alzheimer's dementia
European Archives of Psychiatry and Neurological Sciences, 1989Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method.
E, Sofic +6 more
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Renal gluconeogenesis effects of quinolinic acid
Biochimica et Biophysica Acta (BBA) - General Subjects, 1972Abstract Quinolinic acid, a metabolic degradation product of tryptophan metabolism and a known inhibitor of hepatic gluconeogenesis in vivo, has been shown in the present studies to inhibit renal gluconeogenesis in vitro. At pH 7.4 quinolinic acid decreased glucose production from glutamine and glutamate by rat renal cortex by more than 50%.
S, Klahr, A C, Schoolwerth
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma
1991Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A +3 more
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Quinolinic acid in children with congenital hyperammonemia
Annals of Neurology, 1993AbstractLevels of the excitotoxin quinolinic acid (QUIN) were measured in the cerebrospinal fluid of infants and children with congenital hyperammonemia. Twofold to tenfold elevations of QUIN were found in 4 neonates in hyperammonemic coma (QUIN range, 250–990 nM; control mean, 110 ± 90 nM; p < 0.005).
M L, Batshaw +4 more
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Brain Quinolinic Acid in Huntington's Disease
Journal of Neurochemistry, 1988Abstract: Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method.
G P, Reynolds +3 more
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A photometric method for the determination of quinolinic acid
Archives of Biochemistry and Biophysics, 1953Abstract 1. 1. A photometric method is described for the determination of quinolinic acid in trichloroacetic acid extracts of tissue preparations which have metabolized 3-hydroxyanthranilic acid. 2. 2. The method is based on the measurement of the stable yellow color of the ferrous chelate of quinolinic acid.
M, RABINOVITZ +2 more
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