Results 31 to 40 of about 103,486 (339)

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi, Borgnetto, Brown, Cambau, Champoux, Corbett, Corbett, Ferrero, Fisher, Gatto, Higgins, Kawada, L. M. Fisher, M. Dias, M. Palumbo, Marians, Maxam, McCullough, Mizuuchi, Morrison, Pan, Pan, Pan, Pan, Pan, Peden, Pozzi, Richter, Richter, Richter, Shea, X. S. Pan, Yague, Yoshida, Zechiedrich   +34 more
core   +1 more source

Mechanism of Quinolone Action and Resistance

Biochemistry, 2014
Quinolones are one of the most commonly prescribed classes of antibacterials in the world and are used to treat a variety of bacterial infections in humans. Because of the wide use (and overuse) of these drugs, the number of quinolone-resistant bacterial
Katie J. Aldred, R. Kerns, N. Osheroff
semanticscholar   +1 more source

Resistance pattern of enterobacteriaceae isolates from urinary tract infections to selected quinolones in Yaoundé

The Pan African Medical Journal, 2015
INTRODUCTION: it is estimated that 150 million urinary tract infections (UTIs) occur yearly worldwide, resulting in more than 6 billion dollar in direct healthcare cost.
Emilia Enjema Lyonga, Michel Toukam, Celine Nkenfou, Hortense Kamga Gonsu, Marie-Claire Okomo Assoumou, Martha Tongo Mesembe, Agnes Bedie Eyoh, George Mondinde Ikomey, Valantine Ngum Ndze, Sinata Koulla-Shiro   +9 more
doaj   +1 more source

Synthesis of Quinolones and Zwitterionic Quinolonate Derivatives with Broad-Spectrum Antibiotic Activity

Pharmaceuticals, 2022
Quinolones are one of the most extensively used therapeutic families of antibiotics. However, the increase in antibiotic-resistant bacteria has rendered many of the available compounds useless.
Beatriz Suay-García, Jose-Ignacio Bueso-Bordils, Gerardo Antón-Fos, María-Teresa Pérez-Gracia, Antonio Falcó, Pedro Alemán-López   +5 more
doaj   +1 more source

Exercise-induced tendon and bone injury in recreational runners: A test-retest reliability study [PDF]

, 2015
Background: Long-distance runners are prone to injuries including Achilles tendinopathy and medial tibial stress syndrome. We have developed an Internet comprehensive self-report questionnaire examining the medical history, injury history, and running ...
Compton, Stacey, Domaschenz, Renae, Hughes, David, Keogh, Justin W L, Vlahovich, Nicole   +4 more
core   +1 more source

Distribution of quinolone resistance gene (qnr) in ESBL-producing Escherichia coli and Klebsiella spp. in Lomé, Togo

Antimicrobial Resistance and Infection Control, 2019
Qnr genes are known to confer a low-level resistance to fluoroquinolone in Enterobacteriaceae. They are often found on the same resistance plasmids as extended spectrum β-lactamase (ESBL) and constitute the most common antibiotic resistance mechanism ...
F. Salah, S. Soubeiga, A. Ouattara, A. Sadji, A. Mètuor-Dabiré, D. Obiri-Yeboah, Abiba Banla-Kere, S. Karou, J. Simporé   +8 more
semanticscholar   +1 more source

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp.

Beilstein Journal of Organic Chemistry, 2018
Exploration of rhizobacteria of the genus Burkholderia as an under-tapped resource of bioactive molecules resulted in the isolation of two new antimicrobial 2-alkyl-4-quinolones.
Dandan Li, Naoya Oku, Atsumi Hasada, Masafumi Shimizu, Yasuhiro Igarashi   +4 more
doaj   +1 more source

Ciprofloxacin Concentrations 1/1000th the MIC Can Select for Antimicrobial Resistance in N. gonorrhoeae—Important Implications for Maximum Residue Limits in Food

Antibiotics, 2022
Background: Concentrations of fluoroquinolones up to 200-fold lower than the minimal inhibitory concentration (MIC) have been shown to be able to select for antimicrobial resistance in E. coli and Salmonella spp. (the minimum selection concentration—MSC).
Natalia González, Saïd Abdellati, Irith De Baetselier, Jolein Gyonne Elise Laumen, Christophe Van Dijck, Tessa de Block, Sheeba Santhini Manoharan-Basil, Chris Kenyon   +7 more
doaj   +1 more source

Mechanisms of quinolone action and resistance: where do we stand?

Journal of Medical Microbiology, 2017
Quinolone antibiotics represent one of the most important classes of anti-infective agents and, although still clinically valuable, their use has been compromised by the increasing emergence of resistant strains, which has become a prevalent clinical ...
Susana Correia, P. Poeta, M. Hébraud, J. Capelo, G. Igrejas   +4 more
semanticscholar   +1 more source

Fluorescent Quinoline-Based Supramolecular Gel for Selective and Ratiometric Sensing Zinc Ion with Multi-Modes

Gels, 2022
A gelator 1 containing functional quinoline and Schiff base groups that could form organogels in DMF, DMSO, acetone, ethanol and 1,4-dioxane was designed and synthesized.
Qingqing Han, Qingqing Wang, Aiping Gao, Xuefei Ge, Rong Wan, Xinhua Cao   +5 more
doaj   +1 more source