Results 31 to 40 of about 75,013 (302)
Memorias do Instituto Oswaldo Cruz, 2004 The evaluation of new antimalarial agents using older methods of monitoring sensitivity to antimalarial drugs are laborious and poorly suited to discriminate stage-specific activity.
Carmen E Contreras +6 more
doaj +1 more source
"One Pot" Synthesis of 1,5-Diaza-2,3,6,7-Thetrahydro-4-Methyl-Phenanthrene-4,8-Dione From Corresponding Bis-Beta-Amino Acid [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1999 The cyclization of b-anilino propionic acids in the presence of polyphosphoric acid (PPA) afforded the 2,3-Dihydroquinoline-4-(1H)-ones in good yields. N,N'-bis(2-carboxyethyl)-4-methyl-1,2-diaminobenzene (7) is cyclized under this condition to produce ...
Abbas Shokravi +1 more
doaj
Omadacycline Is Highly Active In Vitro against Mycoplasma genitalium
Microbiology Spectrum, 2022 Here, we performed in vitro susceptibility testing on 10 Mycoplasma genitalium isolates against omadacycline, minocycline, tetracycline, doxycycline, moxifloxacin, levofloxacin, and azithromycin.
Ken B. Waites +4 more
doaj +1 more source
Journal of Medical Microbiology, 2019 Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors such as lectin A, pyocyanin, elastase and rhamnolipids.
Selene García-Reyes +2 more
semanticscholar +1 more source
Development of the quinolones [PDF]
Journal of Antimicrobial Chemotherapy, 2003 Since their discovery in the early 1960s, the quinolone group of antibacterials has generated considerable clinical and scientific interest. Nalidixic acid, the first quinolone to be developed, was obtained as an impurity during the manufacture of quinine.
Alasdair P. MacGowan +1 more
openaire +3 more sources
Word-based GWAS harnesses the rich potential of genomic data for E. coli quinolone resistance
Frontiers in Microbiology, 2023 Quinolone resistance presents a growing global health threat. We employed word-based GWAS to explore genomic data, aiming to enhance our understanding of this phenomenon.
Negin Malekian +5 more
doaj +1 more source
Transferable Mechanisms of Quinolone Resistance from 1998 Onward
Clinical Microbiology Reviews, 2019 While the description of resistance to quinolones is almost as old as these antimicrobial agents themselves, transferable mechanisms of quinolone resistance (TMQR) remained absent from the scenario for more than 36 years, appearing first as sporadic ...
J. Ruiz
semanticscholar +1 more source
Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi
Angewandte Chemie, EarlyView.Type III polyketide synthases (T3PKSs) produce diverse compounds of ecological and clinical importance. Here, the activity of 37 fungal T3PKSs was profiled, revealing unexpected products and generating several pharmaceutical precursors. The machine learning model trained on the activity data accurately extrapolates the predictions to other enzymes and ...
Nika Sokolova +3 more
wiley +2 more sources
Sitafloxacin Expresses Potent Anti-Mycobacterium abscessus Activity
Frontiers in Microbiology, 2022 Therapeutic options for treating Mycobacterium abscessus infections are extremely limited; quinolones are important. The in vitro anti-M. abscessus activities of nine quinolones, emphasizing sitafloxacin, were investigated.
Siyuan He +12 more
doaj +1 more source
Meningococcal Quinolone Resistance Originated from Several Commensal Neisseria Species
Antimicrobial Agents and Chemotherapy, 2019 Quinolone resistance is increasing in Neisseria meningitidis, with its prevalence in China being high (>70%), but its origin remains unknown. The aim of this study was to investigate the donors of mutation-harboring gyrA alleles in N. meningitidis.
Mingliang Chen +3 more
semanticscholar +1 more source