Results 91 to 100 of about 24,157 (222)

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

(4aR*,8aS*)-2,3-Diphenyl-4a,5,6,7,8,8a-hexahydroquinoxaline

Acta Crystallographica Section E, 2012
In the title compound, C20H20N2, the quinoxaline ring adopts a very distorted half-chair conformation [N=C—C=N = 22.7 (2)° for the nominally coplanar atoms] and the cyclohexane ring adopts a chair conformation.
W. Chen, K.-S. Tang, L.-Y. Fan
doaj   +1 more source

Acetylene terminated matrix resins [PDF]

, 1985
The synthesis of resins with terminal acetylene groups has provided a promising technology to yield high performance structural materials. Because these resins cure through an addition reaction, no volatile by-products are produced during the processing.
Arnold, F. E., Goldfarb, I. J., Helminiak, T. E., Lee, Y. C.   +3 more
core   +1 more source

A Comparative Analysis of Maillard‐Derived α‐Dicarbonyl Compounds and Advanced Glycation End Products in Fresh, Wet, Kibble, and Freeze‐Dried Dog Foods

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Thermal processing of pet foods can lead to the formation of harmful Maillard reaction products (MRPs), which may compromise nutritional quality and pose health risks to companion animals. This study compared the levels of MRPs in 41 commercial dog foods, including fresh (n = 15), kibble (n = 13), wet (n = 10), freeze‐dried (n = 2), and cold ...
Tolgahan Kocadağlı, Ciara Clarke, Vural Gökmen   +2 more
wiley   +1 more source

Polyphenylquinoxalines via Aromatic Nucleophilic Displacement [PDF]

Polyphenylquinoxalines are produced by an aromatic nucleophilic displacement reaction involving an activated aromatic dihalide with an appropriate quinoxaline monomer. Polyphenylquinoxalines are high temperature thermoplastics used as adhesives, coatings,
Connell, John W., Hergenrother, Paul M.
core   +1 more source

Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs [PDF]

, 2008
Various novel 10-alkyl-2-deoxo-2-methylthioflavin-5-oxides and their 2-alkylamino derivatives were prepared by facile nitrosative cyclization of 6-(N-alkylanilino)-2-methylthiopyrimidin-4(3H)-ones followed by nucleophilic replacement of the 2-methylthio ...
Ali, Hamed I., Ashida, Noriyuki, Nagamatsu, Tomohisa   +2 more
core   +1 more source

Foodborne Carcinogens: Formation Pathways, Health Risks, and Cutting‐Edge Physical and Chemical Prevention Strategies

eFood, Volume 7, Issue 3, June 2026.
This review highlights the formation of foodborne carcinogens during processing and evaluates different mitigation strategies, including natural antioxidants and modern cooking techniques, to reduce associated cancer risks and enhance food safety. ABSTRACT Food processing methods, though vital for improving food safety, taste, and shelf life, can ...
Naglaa S. Ashmawy, Ahmed A. Zaky, Noha H. Badr, Ali Korin, Mohamed A. Farag   +4 more
wiley   +1 more source

Quinoxaline polymers and copolymers derived from 1, 4-BIS(1'-napthalenyloxayl) benzene [PDF]

A route for the synthesis of a new monomer, 1,4-bis(1'-naphthalenyl)-oxayl benzene, was devised, and six polymers and copolymers were prepared from this monomer, 1,4-bis(phenyloaxaly)benzene, 3,3'-diaminobenzidine and 3,3',4,4'-tetraaminobenzophenone ...
Loszewski, R. C., Port, W. S.
core   +1 more source

Silyl Rearrangements in Gold‐Catalyzed Transformations

European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.
The synergy between the exceptional ability of gold catalysts to activate unsaturated substrates and the inherent tendency of organosilicon reagents to undergo silyl‐group rearrangements has unlocked a range of novel transformations, enabling access to otherwise challenging molecular architectures.
Patricia García‐Martínez, Luis A. López   +1 more
wiley   +1 more source

A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network

Molecules
The quinoxaline core is found in several biologically active compounds, with Erdafitinib being the first FDA-approved quinoxaline derivative that targets a kinase and exhibits anti-cancer properties.
Lidia Boghean, Sarbjit Singh, Kiran K. Mangalaparthi, Smitha Kizhake, Lelisse Umeta, Donn Wishka, Paul Grothaus, Akhilesh Pandey, Amarnath Natarajan   +8 more
doaj   +1 more source