Results 21 to 30 of about 9,595 (171)

Quinoxaline: A comprehension of current pharmacological advancement in medicinal chemistry

European Journal of Medicinal Chemistry Reports, 2022
Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several quinoxalines analogous displayed their distinct pharmacological activities. In the
Suresh Kumar Suthar, Narendra Singh Chundawat, Girdhar Pal Singh, José M. Padrón, Yuvraj Kunwar Jhala   +4 more
doaj   +1 more source

Cinnamil- and Quinoxaline-Derivative Indicator Dyes for Detecting Volatile Amines in Fish Spoilage

Molecules, 2019
Colorimetric indicators are versatile for applications such as intelligent packaging. By interacting with food, package headspace, and/or the ambient environment, color change in these indicators can be useful for reflecting the actual quality and/or ...
Xiaoyu Luo, Loong-Tak Lim
doaj   +1 more source

3-Methyl-1-(prop-2-en-1-yl)quinoxalin-2(1H)-one

Acta Crystallographica Section E, 2010
In the molecule of the title compound, C12H12N2O, the quinoxaline ring is planar with an r.m.s. deviation of 0.007 (15) Å. The dihedral angle between the quinoxaline and propenyl planes is 82.1 (2)°.
Youssef Ramli, Rachid Slimani, Hafid Zouihri, Saïd Lazar, E. M. Essassi   +4 more
doaj   +1 more source

Quinoxaline Derivatives as Antiviral Agents: A Systematic Review

Molecules, 2020
Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen.
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

Push–Pull Derivatives Based on 2,4′-Biphenylene Linker with Quinoxaline, [1,2,5]Oxadiazolo[3,4-B]Pyrazine and [1,2,5]Thiadiazolo[3,4-B]Pyrazine Electron Withdrawing Parts

Molecules, 2022
A series of novel V-shaped quinoxaline, [1,2,5]oxadiazolo[3,4-b]pyrazine and [1,2,5]thiadiazolo[3,4-b]pyrazine push–pull derivatives with 2,4′-biphenylene linker were designed and their electrochemical, photophysical and nonlinear optical properties were
Egor V. Verbitskiy, Pascal le Poul, Filip Bureš, Sylvain Achelle, Alberto Barsella, Yuriy A. Kvashnin, Gennady L. Rusinov, Valery N. Charushin   +7 more
doaj   +1 more source

Mft1, identified from a genome-wide screen of the yeast haploid mutants, mediates cell cycle arrest to counteract quinoxaline-induced toxicity

Frontiers in Genetics
Quinoxaline is a heterocyclic compound with a two-membered ring structure that undergoes redox cycling to produce toxic free radicals. It has antiviral, antibacterial, antifungal, and antitumor activities.
Abdallah Alhaj Sulaiman, Dana E. Al-Ansari, Dana E. Al-Ansari, Reem Ali, Mustapha Aouida, Dindial Ramotar   +5 more
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Poly[(μ-2,3-diethyl-7,8-dimethylquinoxaline-κ2N:N)(2,3-diethyl-7,8-dimethylquinoxaline-κN)-μ-nitrato-κ2O:O′-nitrato-κ2O,O′-disilver(I)]

IUCrData
The structure of the title compound, [C14H18N2)2Ag2](NO3)2, contains subtle differences in ligand, metal, and counter-anion coordination. One quinoxaline ligand uses one of its quinoxaline N atoms to bond to one silver cation. That silver cation is bound
Guy Crundwell, Ashley Leeds
doaj   +1 more source

A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi. [PDF]

PLoS ONE, 2014
BackgroundChagas' disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is considered endemic.
Jean Henrique da Silva Rodrigues, Tânia Ueda-Nakamura, Arlene Gonçalves Corrêa, Diego Pereira Sangi, Celso Vataru Nakamura   +4 more
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Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Antimicrobial Evaluation and Synthesis of Some Phenylpyrazolo benzothiazolo quinoxaline Derivatives

E-Journal of Chemistry, 2009
2,3-Diphenyl quinoxaline (SI) was fused with 2-amino benzothiazoles (SII) by a methylene bridge, which was then allowed for acetylation. The acetylated product (SIV) was made to react with different aromatic aldehydes to give chalcones (SV1-SV5 ...
CH. Sridevi, K. Balaji, A. Naidu, R. Sudhakaran   +3 more
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