A structural blueprint for antibacterial discovery: microwave- and ultrasound-assisted synthesis of pyrrolidine-fused quinoxalines as novel inhibitors of DNA gyrase and biofilm. [PDF]
Fayed EA +6 more
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Bronsted and Lewis Acid-Catalyzed Diverse Functionalization of Indenoquinoxaline-11-Propargyl Alcohols: Synthesis of 4‑Indeno-quinoxalinylidene-2,3-diarylcyclobutenone, 1,2-Dimethoxy-2-Aryl-ethylideneindenoquinoxaline, and 2‑Methoxy-1-phenyldiaza-benzocyclopentafluorenes. [PDF]
Padmashrija AJC +3 more
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Quinoxaline derivatives with broadened absorption patterns
Organic & Biomolecular Chemistry, 2013Quinoxaline-based semiconducting materials are currently of high interest in the field of organic photovoltaics. The number of structural variations employed has been, however, quite limited to date. In this paper we report on the synthesis of a series of quinoxaline monomers and triads with improved optical features.
Lidia, Marin +3 more
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Abstract Base catalysed intramolecular cyclization of α-cyano- o -nitroacetanilides (Ia–d) to the corresponding 2-cyano-3-hydroxyquinoxaline 1-oxides (IIa-d) is described, and a mechanism proposed. The cyanoquinoxaline N-oxides (IIa-d) on reduction are deoxygenated with simultaneous loss of the nitrile group, and when heated with concentrated aqueous
Yusuf Ahmad, M.S. Habib, null Ziauddin
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Synthesis of new quinoxaline derivatives
Russian Journal of Organic Chemistry, 2012Proceeding from 2-aminoquinoxaline-3-carbonitrile 1,4-dioxides new derivatives of quinoxaline and quinoxaline 1,4-dioxide were synthesized containing in the position 3 of the quinoxaline fragment 1,2,4-oxadiazole and tetrazole rings. The acylation of 2-amino-N′-hydroxyquinoxaline-3-carbox imidoamide 1,4-dioxide was investigated.
O. B. Laskina +2 more
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Synthesis of New Quinoxaline Derivatives
Synthetic Communications, 2011Abstract New quinoxaline derivatives were prepared by the reaction of 2-hydroxyquinoxaline 1 and alkyl or alkylaminoalkyl halides in dimethylformamide using potassium carbonate as a base. The hydroxyl group was readily converted into a thiol function by treatment with phosphorus pentasulfide and/or Lawesson's reagent in pyridine, and the subsequent ...
A. Makhloufi +3 more
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Quinoxaline derivatives: a patent review (2006 – present)
Expert Opinion on Therapeutic Patents, 2012Quinoxaline scaffold is included in a large number of therapeutic agents because of its physicochemical properties that make the difference between them and the carbono analogue, naphthalene.This review of patented products presents the quinoxaline heterocycle as part of the structural patent claims from a medicinal chemistry perspective.We centred our
Mercedes, González, Hugo, Cerecetto
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Quinoxaline derivatives of severalalkaloids
Chemistry of Natural Compounds, 2010New quinoxaline derivatives were prepared by reaction of 2-quinoxalinehydroximoylbromide with the alkaloids anabasine, cytisine, and salsoline.
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Quinoxaline Derivatives: Novel and Selective Butyrylcholinesterase Inhibitors
Medicinal Chemistry, 2014Alzheimer's disease (AD) is a progressive brain disorder which occurs due to lower levels of acetylcholine (ACh) neurotransmitters, and results in a gradual decline in memory and other cognitive processes. Acetycholinesterase (AChE) and butyrylcholinesterase (BChE) are considered to be primary regulators of the ACh levels in the brain.
Aurang, Zeb +6 more
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Biological Activity of Quinoxaline Derivatives
2011Quinoxaline derivatives constitute an important class of heterocycles in drug discovery. They areclinically effective as antibacterial, antifungal, anti-inflammatory, anticancer, anti-tubercular andantineoplastic agents. Interestingly, it also shows hypoglycemic and antiglaucoma activity.Modification in their structure has offered a high degree of ...
Yadav Deepika +3 more
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