Results 71 to 80 of about 958,198 (238)

Microbial quorum sensing: a tool or a target for antimicrobial therapy?

, 2009
Inter-cell communication aided by released chemical signals when cell density reaches a critical concentration has been investigated for over 30 years as quorum sensing.
Raina, S., Clements, Mark, Keshavarz, Tajalli, Raina, Sheetal, Clements, M.O., Keshavarz, T., Vanhulle, Sophie, De Vizio, D., De Vizio, Daniela, Odell, Mark, Vanhulle, S., Odell, M., Sophie Vanhulle, Mark Clements, Tajalli Keshavarz, Daniela De Vizio, Sheetal Raina, Mark Odell   +17 more
core   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +2 more sources

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review

Journal of Chemistry
The formation of biofilms occurs due to a group of bacteria gathering together. The increasing of cell density will stimulate chemical signals for bacteria to communicate through quorum sensing system.
Salsabila Aqila Putri, Euis Julaeha, Natsuko Kagawa, Dikdik Kurnia   +3 more
doaj   +1 more source

Reversible Signal Binding by the Pseudomonas aeruginosa Quorum-Sensing Signal Receptor LasR

mBio, 2011
Many members of the LuxR family of acyl-homoserine lactone (acyl-HSL)-dependent quorum-sensing transcriptional activators are thought to have the unusual characteristics of requiring the signal ligand during polypeptide synthesis to fold into an active ...
Kaia J. Sappington, Ajai A. Dandekar, Ken-Ichi Oinuma, E. Peter Greenberg   +3 more
doaj   +1 more source

The Potential of Self‐Maintainable Living Materials

Advanced Science, EarlyView.
Self‐maintainable living materials are presented as the next generation of bioadaptive systems, integrating continuous sensing, decision‐making, response, self‐repair, and adaptation in a closed‐loop framework. This review highlights the design principles and emerging technologies that enable autonomous, long‐term functionality for future regenerative ...
Mohammadsadegh Nadimifar, Tatiane Eufrásio‐da‐Silva, Lidia Maeso, Gorka Orive, Alireza Dolatshahi‐Pirouz   +4 more
wiley   +1 more source

Freestanding PZT Films for Integrated Wearable Sensing and Intelligent Acoustic Recognition

Advanced Science, EarlyView.
A freestanding epitaxial PZT/LaNiO3/Pt heterostructure is achieved via water‐assisted delamination from mica, effectively eliminating substrate‐induced clamping and releasing intrinsic ferroelectricity. The released film exhibits substantially enhanced remanent polarization and piezoelectric response, delivering excellent mechanical flexibility and ...
Hailong Pan, Zhichao Xu, Rongxiao Liu, Jianmei Pei, Changhong Yang, Shifeng Huang, Michael Wübbenhorst   +6 more
wiley   +1 more source

Regulação gênica da biossíntese de violaceína e Quorum sensing em Chromobacterium violaceum [PDF]

, 2005
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia QuímicaA Chromobacterium violaceum é uma bactéria Gram-negativa, violeta-pigmentada, aeróbica facultativa, que vive em regiões de ...
Oliveira, Cristiana Gomes de
core  

Quorum sensing inhibition and Biofilm formation inhibition assay against Chromobacterium and Pseudomonas aeruginosa

, 2023
reservedA major challenge to encounter the chronic infection caused by pseudomonas aeruginosa.This project carried out Two assays to perform antimicrobial susceptibility test against Quorum sensing and Biofilm formation .Quorum sensing inhibition(QSI ...
XXX, SAFOORA SULTHANA
core