Results 111 to 120 of about 17,555 (209)
Phosphatidylinositol-3-OH kinases are Rab5 effectors
Nature Cell Biology, 1999 Nat Cell ...
Christoforidis, S +8 more
openaire +6 more sources
Inhibition of Rab5 Activation During Insulin Receptor-Mediated Endocytosis
, 2011 Activation of receptor tyrosine kinases is a key feature in receptor signaling and membrane trafficking processes. In this study, we found thatthe insulin receptor tyrosine kinase activity is required for fusion between early endosomes.
Barbieri, Manuel Alejandro +3 more
core +3 more sources
Interaction between p85 and Rab5 in the presences and absence of phosphorylated PDGFR peptide [PDF]
, 2012 The adaptor subunit of phosphatidylinositol 3'-kinases (PI3K), p85, is involved in many different biological processes. Recent studies have shown that one of these functions is to serve as a GTPase activating protein (GAP) towards Rab5, a small ...
Bergman, Cody
core
Coordination between ESCRT function and Rab conversion during endosome maturation
The EMBO JournalThe endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5 positive early endosomes receive proteins from the plasma membrane.
Daniel P Ott +4 more
doaj +1 more source
A Protein of 130 kDa Is a New Rab5 Effector
, 2013 (A) GST-Rab5-GDP and GST-Rab-GTPγS were loaded on beads and incubated with bovine brain cytosol. Bound proteins were eluted and analysed by SDS-PAGE followed by Coommasie Blue staining. The positions of the already known Rab5 effectors (EEA1, Rabaptin-5,
Matthias Wilm (52) +6 more
core +1 more source
Development of mRNA–lipid nanoparticle intrabodies against rickettsial infection
Journal of Biomedical ScienceBackground Rickettsiosis is among the deadliest vector-borne infectious diseases worldwide, in part because rickettsiae replicate within human cells, where antibodies and most drugs cannot effectively reach this obligatory intracellular pathogen ...
Qi Yan +7 more
doaj +1 more source
Rab5 regulates internalisation of P2X4 receptors and potentiation by ivermectin
, 2012 The P2X4 receptor is an ATP-gated ion channel expressed in neurons, endothelia and immune cells. Plasma membrane expression of P2X4 is regulated by dynamin-dependent endocytosis, and this study identifies a Rab5-dependent pathway of receptor ...
Leanne Stokes (543342)
core
Characterisation of the involvement of rab5 in early endosome fusion [PDF]
, 1994 The rab5 protein is a member of the rab family of ras-related GTPases, which are known to be involved in the regulation of membrane transport in eukaryotic cells.
Steele-Mortimer, Olivia Ann
core +1 more source
RAB5 accumulates in the cytoplasm of spinal cord neurons of patients with ALS.
, 2015 (A-C) Immuno-enzymatic detection of Rab5 in post-mortem tissues from ALS patients (B,C) and controls (A). RAB5 staining shows punctuate and diffuse distribution of immunoreactivity throughout the cytoplasm, whereas RAB5 accumulates in cytoplasmic ...
Andrea Chai (715360) +6 more
core +1 more source
The roles of Rab5 on yolk granule biogenesis in vitellogenic oocytes.
Confocal fluorescent microscopy and DIC imaging of stage 10 egg chambers from oocytes of (A-D) wildtype control or (E-N) overexpressing (E-H) dominant-negative YFP-Rab5-DN, (I-L) constitutive-active YFP-Rab5-CA and (M, N) wildtype YFP-Rab5, that were (A,
Shiyu Xu (9662931) +8 more
core +1 more source