Revisiting Rab7 Functions in Mammalian Autophagy: Rab7 Knockout Studies [PDF]
Cells, 2018 Rab7 (or Ypt7 in yeast) is one of the well-characterized members of the Rab family small GTPases, which serve as master regulators of membrane trafficking in eukaryotes.
Mitsunori Fukuda
exaly +6 more sources
Multiple Roles of the Small GTPase Rab7 [PDF]
Cells, 2016 Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied.
Cecilia Bucci, Flora Guerra
exaly +7 more sources
Rab7 is required for mesoderm patterning and gastrulation in Xenopus [PDF]
Biology Open, 2021 Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior.
Jennifer Kreis +2 more
doaj +3 more sources
Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling [PDF]
Nature CommunicationsEndosome maturation requires lumen acidification. Is progressive lumen acidification sensed by cytosolic-side molecules driving maturation? We show here that proton efflux through the endosomal Na⁺/H⁺ Exchanger (NHE6) activates the late endosome master ...
YouJin Lee +12 more
doaj +2 more sources
NRP1 promotes hepatic fibrosis by regulating Src/Rab7-mediated lysosomal degradation of TβRI [PDF]
Cell Death DiscoveryBackground and Aims Activation of hepatic stellate cells (HSCs) and subsequent dysregulation of the TGF-β1 signaling pathway are central to the progression of hepatic fibrosis. Neuropilin-1 (NRP1) has been identified as a co-receptor involved in multiple
Zhe Jia, Xiaodong Song, Jie Bai
doaj +2 more sources
Neuroinflammation-induced downregulation of RAB7 in murine astrocytes disrupts endo-lysosomal homeostasis and induces astrogliosis [PDF]
Cell Communication and SignalingBackground Neuroinflammation induces astrogliosis, a process marked by astrocyte hypertrophy, increased migration, and altered protein expression. While these changes involve both up- and downregulation of specific genes, the mechanisms governing protein
Jorge Díaz +16 more
doaj +2 more sources
TBK1 activity regulates the directionality of axonal transport of signalling endosomes [PDF]
Life Science AllianceNeurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7.
David Villarroel-Campos +6 more
doaj +2 more sources
Expected and unexpected roles for dynein regulation of dendritic late endosomes
Autophagy Reports, 2022 Dendrites differ from axons in multiple ways, including the presence of minus-end out microtubules intermixed with the more conventional plus-end out microtubules.
Chan Choo Yap, Bettina Winckler
doaj +1 more source
Effects of Rab7 gene up-regulation on renal fibrosis induced by unilateral ureteral obstruction [PDF]
Brazilian Journal of Medical and Biological Research, 2020 Rab7, an important member of the Rab family, is closely related to autophagy, endocytosis, apoptosis, and tumor suppression but few studies have described its association with renal fibrosis.
Qing Xu +6 more
doaj +2 more sources
Journal of Extracellular Vesicles, 2021 Multivesicular bodies (MVBs) fuse with not only the plasma membranes to release extracellular vesicles (EVs) but also lysosomes for degradation. Rab7 participates in the lysosomal targeting of MVBs.
Xuefeng Fei +14 more
doaj +1 more source