Results 21 to 30 of about 16,571 (204)
Genetic analysis of rab7 mutants in zebrafish [PDF]
, 2023 Vascular network formation requires the fusion of newly formed blood vessels and the emergence of a patent lumen between the newly established connections so that blood flow can start.
Schmelzer, Etienne +15 more
core +3 more sources
Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking [PDF]
Journal of Cell Science, 2017 Retromer is a multimeric protein complex that mediates endosome-to-TGN and endosome-to-plasma membrane trafficking of integral membrane proteins. Dysfunction of this complex has been linked to Alzheimer's and Parkinson's disease.
Peter K. Kim +15 more
core +5 more sources
Early-Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice. [PDF]
Adv Sci (Weinh)Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Chen K, He B, Liu K, Ma Z, Xu B.
europepmc +2 more sources
CMT2B-associated Rab7 mutants inhibit neurite outgrowth
Acta Neuropathologica, 2010 Charcot-Marie-Tooth type 2B (CMT2B) neuropathy is a rare autosomal-dominant axonal disorder characterized by distal weakness, muscle atrophy, and prominent sensory loss often complicated by foot ulcerations. CMT2B is associated with mutations of the Rab7
BUCCI, Cecilia +5 more
core +4 more sources
Expressing DN Rab7 depletes most GTP-Rab7.
, 2023 Lysates from HeLa S3 cells or those stably transduced with an empty vector or a plasmid expressing dominant negative Rab7 (Rab7 DN) were pulled down with GST or GST-RILP (IP) and subjected to Western blot analysis using antibodies recognizing Rab7 or GST
Jeongjoon Choi (163948) +1 more
core +1 more source
Biology Open, 2020 Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN).
Prajal H. Patel +5 more
doaj +1 more source
Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering
Scientific Reports, 2021 The membrane contact sites (MCSs) between the ER and late endosomes (LEs) are essential for the regulation of endosomal protein sorting, dynamics, and motility.
Haider Khan +3 more
doaj +1 more source
Adrenergic Contraction of Human Prostate Tissues Is Maintained Under the Rab GTPase Inhibitors Nexhinib20 and CID1067700 [PDF]
Pharmacol Res PerspectABSTRACT α1‐Adrenoceptors are an important drug target in benign prostatic hyperplasia (BPH) and have been intensively studied at the expression level, but their posttranslational regulation in the prostate is widely unknown. Here we examined modulation of prostate smooth muscle contractions by inhibitors for RabGTPases, which are involved in ...
Troffer L +9 more
europepmc +2 more sources
A conserved and regulated mechanism drives endosomal Rab transition
eLife, 2020 Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation,
Lars Langemeyer +8 more
doaj +1 more source
Scientific Reports, 2023 Rab7 is known to function in the autophagy and endocytosis pathways in eukaryocytes and is related to various diseases. We recently reported that Rab7 plays a protective role against acute pancreatitis.
Kenichi Takahashi +7 more
doaj +1 more source