Results 41 to 50 of about 16,571 (204)
Rab7: roles in membrane trafficking and disease
Bioscience Reports, 2009 The endocytosis pathway controls multiple cellular and physiological events. The lysosome is the destination of newly synthesized lysosomal hydrolytic enzymes. Internalized molecules or particles are delivered to the lysosome for degradation through sequential transport along the endocytic pathway. The endocytic pathway is also emerging as a signalling
Zhang, Ming +3 more
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Cells, 2023 In B cells, antigen processing and peptide-antigen (pAg) presentation is essential to ignite high-affinity antibody responses with the help of cognate T cells.
Marika Runsala +7 more
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, 2022 Chronic alcohol consumption retards lipophagy, which contributes to the pathogenesis of liver steatosis. Lipophagy-related Rab7 has been presumed as a crucial regulator in the progression of alcohol liver disease despite elusive mechanisms.
Huimin Chen +13 more
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The EMBO Journal, 2017 Retromer is an endosomal multi-protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional retromer function in controlling the activity and localization of the late endosomal small GTPase RAB7. Surprisingly, we found that RAB7 not only decorates late endosomes or lysosomes, but
Ana Jimenez‐Orgaz +6 more
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Role of the Small GTPase RAB7 in the Late Endocytic Pathway [PDF]
Journal of Biological Chemistry, 1997 Rab7 is a small GTPase localized to the late endosomal compartment. Its function was investigated by overexpressing dominant negative or constitutively active mutants in BHK-21 cells. The effects of such overexpression on the internalization and/or degradation of different endocytic markers and on the morphology of the late endosomal compartment were ...
VITELLI R +6 more
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Role for Rab7 in maturation of late autophagic vacuoles [PDF]
Journal of Cell Science, 2004 The small GTP binding protein Rab7 has a role in the late endocytic pathway and lysosome biogenesis. The role of mammalian Rab7 in autophagy is, however, unknown. We have addressed this by inhibiting Rab7 function with RNA interference and overexpression of dominant negative Rab7.
JAGER S. +6 more
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Formation of the ORP1-Rab7-RILP complex.
, 2019 (A) Binding interface of the ORP1 ANK and Rab7. The residues forming the interface are shown in stick models. The hydrogen bonds are shown in dashed lines. (B) Measurement of binding affinity of ORP1 ANK to Rab7 by isothermal titration calorimetry.
Lingchen Tan (6298421) +3 more
core +1 more source
Supporting a role for the GTPase Rab7 in prostate cancer progression. [PDF]
PLoS ONE, 2014 Invasion and subsequent metastasis is the major cause of death from most cancers including prostate cancer. Herein we report on the potential tumor suppressive properties of Rab7, a GTPase that regulates trafficking of lysosomes.
Joshua J Steffan +7 more
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Kinetics of Interaction of Rab5 and Rab7 with Nucleotides and Magnesium Ions [PDF]
Journal of Biological Chemistry, 1996 We describe here the kinetics of the interaction of GTP and GDP with the small GTP-binding proteins Rab5 and Rab7. It was possible to make use of the intrinsic fluorescence of these proteins, since Rab5 contains two and Rab7 three tryptophan residues, respectively. With both enzymes, there is a significant decrease in fluorescence on binding GTP and an
Simon, I., Zerial, M., Goody, R.
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Rab7 Phosphorylation reaction v1
, 2023 Phosphorylation of Rab7 at S72 using TBK1
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