ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism
Cell Reports, 2017 Hepatic lipid droplet (LD) catabolism is thought to occur via cytosolic lipases such as adipose triglyceride lipase (ATGL) or through autophagy of LDs, a process known as lipophagy.
Douglas Mashek +2 more
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Targeting lipophagy and nuclear receptors in metabolic-associated fatty liver disease: insights from traditional Chinese medicine [PDF]
Frontiers in PharmacologyBackground: Metabolic associated fatty liver disease (MAFLD) represents a globally prevalent chronic hepatic disorder hallmarked by excessive lipid accumulation within hepatocytes.
Ting Yue +13 more
doaj +4 more sources
Cells, 2022 Recently, we developed Komagataella phaffii (formerly Pichia pastoris) as a model for lipophagy, the selective autophagy of lipid droplets (LDs). We found that lipophagy pathways induced by acute nitrogen (N) starvation and in stationary (S) phase have ...
Ravinder Kumar +2 more
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Macrophage lipophagy in atherosclerosis: from molecular mechanisms to traditional Chinese medicine interventions [PDF]
Frontiers in PharmacologyMacrophage lipophagy, the selective autophagic degradation of intracellular lipid droplets, plays a central role in maintaining lipid homeostasis and has emerged as a promising therapeutic target for atherosclerosis (AS).
Ying Hu +8 more
doaj +2 more sources
Seeing is believing: visualizing spatiotemporal lipophagic flux in vivo with the tfLiveDrop reporter mice [PDF]
Autophagy ReportsLipophagy, the selective autophagic degradation of lipid droplets (LDs), is central to cellular lipid homeostasis, yet its dynamic regulation in living organisms has remained largely unobservable in real time.
Siqiao Gong, Chen Yang, Huafeng Liu
doaj +2 more sources
Emerging Roles of Lipophagy in Health and Disease
Frontiers in Cell and Developmental Biology, 2019 The term lipophagy is used to describe the autophagic degradation of lipid droplets, the main lipid storage organelles of eukaryotic cells. Ever since its discovery in 2009, lipophagy has emerged as a significant component of lipid metabolism with ...
Nektarios Tavernarakis, Maria Markaki
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Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy [PDF]
Advanced ScienceSenile osteoporosis (SOP) is characterized by impaired osteogenesis of bone‐marrow mesenchymal stem cells (MSCs). The underlying metabolic basis remains unclear.
Chaoqiang Chen +8 more
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PLIN3-triggered lipophagic flux releases FFAs to facilitate CSFV propagation [PDF]
VirulenceViruses hijack host metabolic resources for replication. Previous studies have shown that classical swine fever virus (CSFV) infection induces host lipid metabolic reprogramming.However, research into the exact regulatory mechanisms between CSFV and ...
Bingke Li +14 more
doaj +2 more sources
Low Shear Stress Promotes Atherosclerosis by Mediating Pathological Accumulation of Endothelial Lipid Droplets via the KLF4/TFEB/ATP1A1 Axis [PDF]
Journal of Cardiovascular Development and DiseaseBackground: Atherosclerosis preferentially develops at arterial regions exposed to low shear stress (LSS), highlighting the critical role of local hemodynamic forces in disease initiation and progression.
Yi Shi +7 more
doaj +2 more sources
The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
Frontiers in Pharmacology, 2023 Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease with increasing prevalence. Lipophagy is a type of programmed cell death that plays an essential role in maintaining the body’s balance of fatty acid metabolism.
Xiangyun Tan +7 more
doaj +1 more source