Results 31 to 40 of about 6,137 (162)
Lipophagy: Connecting Autophagy and Lipid Metabolism [PDF]
, 2012 Lipid droplets (LDs), initially considered “inert” lipid deposits, have gained during the last decade the classification of cytosolic organelles due to their defined composition and the multiplicity of specific cellular functions in which they are ...
Ana Maria Cuervo, Rajat Singh
core +1 more source
AmAtg2B-Mediated Lipophagy Regulates Lipolysis of Pupae in Apis mellifera
, 2023 Lipophagy plays an important role in regulating lipid metabolism in mammals. The exact function of autophagy-related protein 2 (Atg2) has been investigated in mammals, but research on the existence and functions of Atg2 in Apis mellifera (AmAtg2) is ...
Wen-Feng Chen +9 more
core +1 more source
Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy [PDF]
J Inherit Metab DisABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Maddaluno M +3 more
europepmc +2 more sources
Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection
Frontiers in Microbiology, 2021 Diseases caused by Flaviviridae have a wide global and economic impact due to high morbidity and mortality. Flaviviridae infection usually leads to severe, acute or chronic diseases, such as liver injury and liver cancer resulting from hepatitis C virus (
Keke Wu +19 more
doaj +1 more source
Author response: AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation [PDF]
, 2017 Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability are unclear. We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells ...
Prabuddha Sengupta +15 more
core +1 more source
Cell Death and Disease, 2021 Autophagy-mediated lipotoxicity plays a critical role in the progression of diabetic nephropathy (DN), but the precise mechanism is not fully understood. Whether lipophagy, a selective type of autophagy participates in renal ectopic lipid deposition (ELD)
Yachun Han +11 more
doaj +1 more source
Microbiology Spectrum, 2023 During yeast stationary phase, a single spherical vacuole (lysosome) is created by the fusion of several small ones. Moreover, the vacuolar membrane is reconstructed into two distinct microdomains.
Fan Qiu +7 more
doaj +1 more source
, 2022 Zika virus (ZIKV) is a globally transmitted mosquito-borne pathogen, and no effective treatment or vaccine is available yet. Lipophagy, a selective autophagy targeting lipid droplets (LDs), is an emerging subject in cellular lipid metabolism and energy ...
Zhao-Ling Qin (14043981) +4 more
core +1 more source
Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy
, 2017 Robust dengue virus (DENV) replication requires lipophagy, a selective autophagy that targets lipid droplets. The autophagic mobilization of lipids leads to increased β-oxidation in DENV-infected cells.
Tristan X. Jordan, Glenn Randall
core +1 more source
Alterations of Lipid Profile in Livers with Impaired Lipophagy
, 2022 Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Various mechanisms such as an increased uptake in fatty acids or de novo synthesis contribute to the development of steatosis and progression to more
Jonas, Wenke +15 more
core +1 more source