Results 21 to 30 of about 6,137 (162)
Cell Death and Disease, 2022 Autophagy is a conserved method of quality control in which cytoplasmic contents are degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid metabolism, has recently received much attention.
Sheng Zhang +11 more
doaj +1 more source
Lipophagy: Molecular Mechanisms and Implications in Hepatic Lipid Metabolism
Frontiers in Bioscience-Landmark, 2023 The liver is the most significant metabolic organ in the body and plays an important role in lipid metabolism. Liver lipid metabolism disorders cause hepatic diseases such as hepatitis, hepatic cirrhosis, and hepatoma.
Sai Feng +8 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Zika virus (ZIKV) is a globally transmitted mosquito-borne pathogen, and no effective treatment or vaccine is available yet. Lipophagy, a selective autophagy targeting lipid droplets (LDs), is an emerging subject in cellular lipid metabolism and energy ...
Zhao-Ling Qin +4 more
doaj +1 more source
Redox Biology, 2020 Exercise and dietary intervention are currently available strategies to treat nonalcoholic fatty liver disease (NAFLD), while the underlying mechanism remains controversial.
Yu Gao +9 more
doaj +1 more source
Lipophagy: a new player in CNS disorders
, 2021 Lipophagy is the process of selective degradation of lipid droplets (LDs) by autophagy. Several studies have highlighted the importance of lipophagy in regulating cellular lipid levels in various tissues and disease conditions.
HENDRIKS, Jerome +3 more
core +1 more source
The Role of Macrophage Lipophagy in Reverse Cholesterol Transport [PDF]
, 2017 Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis.
Mi-Ni Lee, Goo Taeg Oh, Se-Jin Jeong
core +2 more sources
Macrophage Lipid Homeostasis Drives IVDD via a Senescence-Dependent Impairment of Efferocytosis. [PDF]
Cell ProlifIntervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Wang J +12 more
europepmc +2 more sources
Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis
, 2020 The autophagic degradation of lipid droplets (LDs), termed lipophagy, is a major mechanism that contributes to lipid turnover in numerous cell types. While numerous factors, including nutrient deprivation or overexpression of PNPLA2/ATGL (patatin-like ...
Michael Lopresti (3351341) +5 more
core +1 more source
eLife, 2017 Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability are unclear. We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells ...
Arnold Y Seo +7 more
doaj +1 more source
Quercetin enhances fatty acid β-oxidation by inducing lipophagy in AML12 hepatocytes
Heliyon, 2021 Recent evidence demonstrated that chronic intake of quercetin attenuated hepatic fat accumulation in various animal models of obesity and diabetes. However, whether quercetin has the ability to enhance energy metabolism in hepatocytes and its exact ...
Misato Fukaya +5 more
doaj +1 more source