Results 11 to 20 of about 6,137 (162)

The regulatory role of lipophagy in central nervous system diseases

Cell Death Discovery, 2023
Lipid droplets (LDs) are the organelles for storing neutral lipids, which are broken down when energy is insufficient. It has been suggested that excessive accumulation of LDs can affect cellular function, which is important to coordinate homeostasis of ...
Zhuo-qing Lan, Zi-yi Ge, Shu-kai Lv, Bing Zhao, Cai-xia Li   +4 more
doaj   +2 more sources

Identification and Analysis of Biomarkers Associated with Lipophagy and Therapeutic Agents for COVID-19

Viruses
Background: Lipids, as a fundamental cell component, play an regulating role in controlling the different cellular biological processes involved in viral infections.
Yujia Wu, Zhenlin Wu, Qiying Jin, Jinyuan Liu, Peiping Xu   +4 more
doaj   +2 more sources

Bibliometric analysis of lipophagy:2013 to 2023

Heliyon
Lipophagy is defined as the autophagic degradation of lipid droplets. It is a selective autophagy process that can continuously circulate and redistribute metabolites to maintain the body's energy balance.
Lu Zhao, Mengmeng Pang, Zhenyue Fu, Huaqin Wu, Qingqiao Song   +4 more
doaj   +2 more sources

Lipophagy and Alcohol-Induced Fatty Liver [PDF]

Frontiers in Pharmacology, 2019
This review describes the influence of ethanol consumption on hepatic lipophagy, a selective form of autophagy during which fat-storing organelles known as lipid droplets (LDs) are degraded in lysosomes.
Li Yang, Changqing Yang, Paul G. Thomes, Paul G. Thomes, Kusum K. Kharbanda, Kusum K. Kharbanda, Carol A. Casey, Carol A. Casey, Mark A. McNiven, Terrence M. Donohue, Terrence M. Donohue   +10 more
doaj   +4 more sources

ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy

Journal of Advanced Research
Introduction: Atherosclerosis, a major contributor to cardiovascular disease, remains a significant health concern worldwide. While previous research has shown that acid-sensing ion channel 1 (ASIC1) impedes macrophage cholesterol efflux, its precise ...
Yuan-Mei Wang, Huang Tang, Ya-Jie Tang, Juan Liu, Yu-Fang Yin, Ya-Ling Tang, Yao-Guang Feng, Hong-Feng Gu   +7 more
doaj   +2 more sources

PLIN5 contributes to lipophagy of hepatic stellate cells induced by inorganic arsenic

Ecotoxicology and Environmental Safety
Arsenic exposure triggers the activation of hepatic stellate cells (HSCs), resulting in liver fibrosis (LF). A significant decrease in lipid droplets marks the activation of HSCs.
Haomiao Li, Xuri Xie, Tianming Qiu, Jingyuan Zhang, Jie Bai, Guang Yang, Ningning Wang, Xiaofeng Yao, Xiance Sun   +8 more
doaj   +2 more sources

All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells [PDF]

Journal of Lipid Research
All-trans retinoic acid (atRA), a metabolite of vitamin A, reduces hepatic lipid accumulation in liver steatosis model animals. Lipophagy, a new lipolysis pathway, degrades a lipid droplet (LD) via autophagy in adipose tissue and the liver.
Anh The Nguyen, Masashi Masuda, Yuki Mori, Yuichiro Adachi, Teppei Fukuda, Airi Furuichi, Masaki Takikawa, Yuki Tsuda, Yuki Hamada, Yusuke Maruyama, Hirokazu Ohminami, Kohta Ohnishi, Yutaka Taketani   +12 more
doaj   +2 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion

Nature Communications, 2023
Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid accumulation and subsequent inflammatory and profibrotic response.
Yoshito Minami, Atsushi Hoshino, Yusuke Higuchi, Masahide Hamaguchi, Yusaku Kaneko, Yuhei Kirita, Shunta Taminishi, Toshiyuki Nishiji, Akiyuki Taruno, Michiaki Fukui, Zoltan Arany, Satoaki Matoba   +11 more
doaj   +1 more source

Identifying the Genetic Determinants of Lipophagy in Saccharomyces cerevisiae [PDF]

, 2023
Lipid droplet (LD) autophagy (lipophagy) is a recently discovered selective form of autophagy and is a pathway for LD catabolism through the lysosome or vacuole.
Fairman, Garrett
core   +1 more source