Results 41 to 50 of about 6,137 (162)

Inhibited Lipophagy Suppresses Lipid Metabolism in Zebrafish Liver Cells

Frontiers in Physiology, 2019
Lipophagy degrades lipid droplets (LDs) through the lysosomal degradative pathway, thus plays important roles in regulating lipid metabolism in mammals.
Jing Wang, Si-Lan Han, Dong-Liang Lu, Ling-Yu Li, Samwel Mchele Limbu, Samwel Mchele Limbu, Dong-Liang Li, Mei-Ling Zhang, Zhen-Yu Du   +8 more
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Resveratrol promotes hepatic lipid decomposition by regulating ATGL/CGI58 and Rab7/LC3β through perilipin 2

陆军军医大学学报, 2023
Objective To investigate the effect of resveratrol (RSV) on enhancing hepatic lipolysis and lipophagy through perilipin 2 (PLIN2), and elucidate its underlying mechanism.
YANG Yilin, ZHANG Yan, QIN Yu, MI Mantian   +3 more
doaj   +1 more source

Improving Lipophagy by Restoring Rab7 Cycle: Protective Effects of Quercetin on Ethanol-Induced Liver Steatosis

, 2022
Chronic alcohol consumption retards lipophagy, which contributes to the pathogenesis of liver steatosis. Lipophagy-related Rab7 has been presumed as a crucial regulator in the progression of alcohol liver disease despite elusive mechanisms.
Huimin Chen, Peiyi Liu, Ping Yao, Wen Liu, Guibin Mei, Jingjing Liu, Xiaoping Guo, Chunjie Jiang, Ying Zhao, Li Chen, Yaqin Yu, Hongxia Li, Dan Li, Hongkun Lin   +13 more
core   +1 more source

The role of lipophagy in liver cancer: mechanisms and targeted therapeutic interventions

Frontiers in Cell and Developmental Biology
Liver cancer, the advanced stage of various chronic liver diseases, has garnered attention due to its high incidence and insidious progression. Lipid droplets (LDs), unique lipid storage organelles in hepatocytes, play a pivotal role in lipid metabolism.
Peiyu Han, Peiyu Han, Han Wang, Yuyu Chen, Yuqiu Ge, Huiting Xu, Hongbo Ren, Yiteng Meng   +7 more
doaj   +1 more source

The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease [PDF]

, 2021
Non-alcoholic fatty liver disease (NAFLD) or metabolic (dysfunction) associated liver disease (MAFLD), is, with a global prevalence of 25%, the most common liver disorder worldwide.
Larsen, Lars E, Holleboom, Adriaan G, van de Peppel, Ivo P, Grefhorst, Aldo, Jonker, Johan W; id_orcid, Johan W. Jonker, Aldo Grefhorst, Lars E. Larsen, Adriaan G. Holleboom, Ivo P. van de Peppel   +9 more
core   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Calycosin alleviates myocardial injury in diabetic mice by enhancing lipophagy in cardiomyocytes via Rab7a regulation

Frontiers in Pharmacology
BackgroundDiabetic cardiomyopathy (DCM) is a major life-threatening cardiovascular complication of diabetes mellitus, characterized by myocardial lipid deposition, lipotoxicity and progressive cardiac dysfunction.
Qi Zhang, Mingyu Li, Xiaowan Zhao, Yuchun Wang, Yiwen Jiang, Yu Feng, Ming Wang, Honglian Zhang, Pengling Ge, Jianwen Zhou, Jicheng Liu   +10 more
doaj   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Liquiritigenin Ameliorates High‐Fat Diet‐Induced Hepatic Steatosis by Promoting Lipid Droplet Catabolism via PLIN2‐ATGL Regulation

Phytotherapy Research, EarlyView.
Liquiritigenin promotes expression of CGI‐58 and enhances lipolysis by down‐regulating expression of PLIN2, thereby facilitating the catabolism of larger‐sized lipid droplets and producing smaller‐sized lipid droplets, resulting in enhanced activity of lipophagy and ameliorated hepatic steatosis. ABSTRACT Metabolic‐associated fatty liver disease (MAFLD)
Zhuoya Xu, Jingmiao Chen, Hong Qin, Yansong Fu, Cunqi Lv, Zhipeng Wang, Xi Liu, Wenya Zheng   +7 more
wiley   +1 more source