Results 61 to 70 of about 6,137 (162)

Low‐dose caffeine administration increases fatty acid utilization and mitochondrial turnover in C2C12 skeletal myotubes

Physiological Reports, 2020
Caffeine has been shown to directly increase fatty acid oxidation, in part, by promoting mitochondrial biogenesis. Mitochondrial biogenesis is often coupled with mitophagy, the autophagy‐lysosomal degradation of mitochondria.
David S. Enyart, Chelsea L. Crocker, Jennifer R. Stansell, Madeleine Cutrone, Meghann M. Dintino, Stephen T. Kinsey, Stephan L. Brown, Bradley L. Baumgarner   +7 more
doaj   +1 more source

Mortality in Salmon (Salmo salar) Fry Related to Lipoid Liver Disease Induced by Unbalanced Fatty Acid Composition of the Diet

Journal of Fish Diseases, EarlyView.
ABSTRACT In 2023, all but one Swedish restocking farm rearing Baltic salmon and sea trout fry experienced massive mortality caused by lipoid liver disease (LLD). The struck farms used the same feed, and this was suspected to be the cause of the outbreak.
Caroline Ek, Lo Persson, Charlotte Axén
wiley   +1 more source

Emerging risk factors influencing the occurrence of peri‐implantitis

Periodontology 2000, EarlyView.
Abstract Background The objective of the present review is to explore the evidence and biological plausibility of factors that may expose dental implants to a greater likelihood of developing peri‐implantitis. Material and Methods An electronic screening on the PubMed library the was carried out to identify potential emerging factors that influence the
Alberto Monje, Ronald E. Jung, Cristina Valles, Nadja Naenni   +3 more
wiley   +1 more source

Research Progress on Lipophagy-Mediated Exercise Intervention in Non-Alcoholic Fatty Liver Disease

Lipophagy is a cellular pathway targeting the lysosomal degradation of lipid droplets, playing a role in promoting lipid turnover and renewal. Abnormal lipophagy processes can lead to the occurrence and development of non-alcoholic fatty liver disease ...
Shuzhe Ding, Xi Li, Yangjun Yang, Yi Sun, Yang, Yangjun, Ding, Shuzhe, Li, Xi, Sun, Yi   +7 more
core   +1 more source

Forced lipophagy reveals that lipid droplets are required for early embryonic development in mouse

, 2018
Although autophagy is classically viewed as a non-selective degradation system, recent studies have revealed that various forms of selective autophagy also play crucial physiological roles.
Atsushi Yamamoto, Satoshi Tsukamoto, Naoyuki Miyasaka, Naojiro Minami, Toshiro Kubota, Akira Matsuura, Takayuki Tatsumi, Shunsuke Ishii, Eisuke Itakura, Taichi Hara, Kaori Takayama   +10 more
core   +1 more source

Lipolysis and lipophagy in lipid storage myopathies

, 2016
Aims: Triglycerides droplets are massively stored in muscle in Lipid Storage Myopathies (LSM). We studied in muscle regulators of lipophagy, the expression of the transcription factor-EB (TFEB) (a master regulator of lysosomal biogenesis), and markers of
Cenacchi G., Angelini C., Nascimbeni A. C., Tasca E.   +3 more
core   +2 more sources

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Targeting Lipophagy in Liver Diseases: Impact on Oxidative Stress and Steatohepatitis

Antioxidants
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of liver conditions, from simple hepatic steatosis to its more severe inflammatory form known as metabolic dysfunction-associated steatohepatitis (MASH).
Jin Seok Hwang, Trang Huyen Lai, Deok Ryong Kim   +2 more
doaj   +1 more source

Uncarboxylated Osteocalcin Is Associated With Improved Energy Metabolism and Reduced Hepatic Lipid Accumulation in Postpartum Dairy Cows

eFood, Volume 7, Issue 6, December 2026.
The study found that uncarboxylated osteocalcin (unOCN) regulates energy metabolism in postpartum dairy cows by promoting the secretion of adiponectin and glucagon‐like peptide‐1. Furthermore, unOCN acts directly on the liver, activating the hepatic AMPK‐PPARα pathway, which consequently reduces lipid accumulation in the liver.
Zhantao Yang, Xiaojing Liu, Yangyi Hao, Yajing Wang, Zhijun Cao, Hongjian Yang, Wei Wang, Bo Hu, Bowen Zheng, Shengli Li   +9 more
wiley   +1 more source

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3770-3777, November 2026.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source