Results 81 to 90 of about 6,137 (162)

The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation

Veterinary Research
25-Hydroxycholesterol (25HC) is a hydroxylated cholesterol with multiple antiviral activities, however, little is known about the mechanisms by which 25HC correlates antiviral ability with lipid droplet (LD) dynamic balance to ensure cholesterol ...
Jia-lu Zhang, Xue-fei Wang, Jia-lin Li, Cong Duan, Jiu-feng Wang   +4 more
doaj   +1 more source

Microlipophagy from Simple to Complex Eukaryotes

Cells
Lipophagy is a selective degradation of lipid droplets in lysosomes or vacuoles. Apart from its role in generating energy and free fatty acids for membrane repair, growth, and the formation of new membranes, lipophagy emerges as a key player in other ...
Ravinder Kumar, Colin Arrowood, Micah B. Schott, Taras Y. Nazarko   +3 more
doaj   +1 more source

Targeting Adipose Tissue Lipid Metabolism to Improve Glucose Metabolism in Cardiometabolic Disease [PDF]

European Medical Journal Diabetes, 2014
With Type 2 diabetes mellitus and cardiovascular disease prevalence on the rise, there is a growing need for improved strategies to prevent or treat obesity and insulin resistance, both of which are major risk factors for these chronic diseases ...
Johan W.E. Jocken, Gijs H. Goossens, Ellen E. Blaak   +2 more
doaj  

Pro-survival signaling regulates lipophagy essential for multiple myeloma resistance to stress-induced death

Pro-survival metabolic adaptations to stress in tumorigenesis remain less well defined. We find that multiple myeloma (MM) is unexpectedly dependent on beta-oxidation of long-chain fatty acids (FAs) for survival under both basal and stress conditions ...
Utley, Adam, Olejniczak, Scott H., Lee, Kelvin P., Peng, Peng, Chavel, Colin, Cao, Sha, Carlson, Louise M., Liu, Wensheng   +7 more
core   +1 more source

Hyperlipidemia Impacts Osteogenesis Via Lipophagy Mediated By Optn-Rab18 Interaction

International Dental Journal
Aim or purpose: The high-fat environment impairs osteoblast function and activates lipophagy; however, promoting lipophagy may improve osteogenesis under certain conditions. The underlying mechanisms are unclear.
Chonghao Ji, Xiaoyan Chen, Lehan Xu
doaj   +1 more source

LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced lipophagy in yeast [PDF]

Lipid droplets (LDs) are fat storage organelles critical for energy and lipid metabolism. Upon nutrient exhaustion, cells consume LDs via gradual lipolysis or via lipophagy, the en bloc uptake of LDs into the vacuole.
Broeskamp, Filomena, Infant, Terence,, Höög, Johanna L., Büttner, Sabrina,, Gabrijelčič, Sonja,, de Ory, Ana,, Álvarez-Guerra, Irene,, Habernig, Lukas,, Block, Emma,, Andréasson, Claes,, Levine, Tim P.   +10 more
core   +2 more sources

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway [PDF]

, 2019
Fatty acid translocase CD36 (CD36) is a multifunctional membrane protein that facilitates the uptake of long-chain fatty acid (LCFA). Lipophagy is autophagic degradation of lipid droplets.
Moorhead, JF, Ruan, XZ, Yang, P, Li, Y, Wei, L, Varghese, Z, Chen, Y, Zeng, S, Zhang, X, Zhao, L   +9 more
core   +1 more source

Lipophagy acts as a nutritional adaptation mechanism for the filamentous entomopathogenic fungus Beauveria bassiana to colonize within the hosts

Journal of Advanced Research
Introduction: Metabolic adaptation to various nutrients is crucial for the pathogenic growth and virulence of filamentous fungal pathogens. Despite its importance, the mechanisms underlying fungal adaptation to nutrient shifts, especially at the ...
Jin-Li Ding, Ming-Guang Feng, Sheng-Hua Ying   +2 more
doaj   +1 more source

Identification and Validation of Key Genes Related to Lipophagy in Osteoporosis

Orthopedic Research and Reviews
Yixin Hu,* Mingliang Zuo,* Yu Wu,* Yu Yang, Xiaobing Shi, Qian Zhang, Ji Wu, Runqi Xie, Yu Bi, Bo Lin, Chou Mo Department of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, Guizhou, People’s Republic of China& ...
Hu YX, Zuo ML, Wu Y, Yang Y, Shi XB, Zhang Q, Wu J, Xie RQ, Bi Y, Lin B, Mo C   +10 more
doaj  

Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function

Cell Death and Disease
Lipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal decay and has been implicated in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD).
Yuanyuan Qin, Sheila S. Teker, Nilsa La Cunza, Yao Tong, Elizabeth Theusch, Neil V. Yang, Leela Venkatesan, Julia Su, Xuanwen Wang, Ronald M. Krauss, Aparna Lakkaraju, Aras N. Mattis, Marisa W. Medina   +12 more
doaj   +1 more source