Results 71 to 80 of about 6,137 (162)

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover

Nature Communications
Lipid droplets (LDs) are dynamic lipid storage organelles that can be degraded by autophagy machinery to release neutral lipids, a process called lipophagy. However, specific receptors and regulation mechanisms for lipophagy remain largely unknown. Here,
Zhen Yuan, Kun Cai, Jiajia Li, Ruifeng Chen, Fuhai Zhang, Xuan Tan, Yaming Jiu, Haishuang Chang, Bing Hu, Weiyi Zhang, Binbin Ding   +10 more
doaj   +1 more source

Telemetric control of peripheral lipophagy by hypothalamic autophagy

Autophagy maintains cellular quality control by degrading organelles, and cytosolic proteins and their aggregates in lysosomes. Autophagy also degrades lipid droplets (LD) through a process termed lipophagy.
Martinez-Lopez N, Singh R
core   +1 more source

Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment

Diabetes, Metabolic Syndrome and Obesity, 2021
Mingyue Huang,1,2,* Xinyu Yang,2,* Zhenzhen Wang,3 Jianglan Long,3 Aiting Wang,3 Yi Zhang,4 Dan Yan3 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, People’s Republic of China; 2Beijing Key Laboratory of
Huang M, Yang X, Wang Z, Long J, Wang A, Zhang Y, Yan D   +6 more
doaj  

Review Article: Fibrosis Reversal in Metabolic Dysfunction‐Associated Steatohepatitis—The Promise of Emerging Therapeutics

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1184-1196, November 2026.
Metabolic dysfunction‐associated steatohepatitis is the second commonest US indication for liver transplantation but remains largely undiagnosed and untreated. Fibrosis stage is the strongest predictor of major adverse liver outcomes, with decompensation rates and transplant‐free survival diverging sharply between F3 and F4, while cardiovascular ...
Malek Ayoub, Tsubasa Tsutsumi, Mary E. Rinella   +2 more
wiley   +1 more source

Table_1_Inhibited Lipophagy Suppresses Lipid Metabolism in Zebrafish Liver Cells.docx

, 2019
Lipophagy degrades lipid droplets (LDs) through the lysosomal degradative pathway, thus plays important roles in regulating lipid metabolism in mammals.
Jing Wang (6206297), Dong-Liang Lu (5807432), Zhen-Yu Du (350261), Mei-Ling Zhang (765444), Si-Lan Han (7295669), Samwel Mchele Limbu (7295672), Ling-Yu Li (4922107), Dong-Liang Li (4341280)   +7 more
core   +1 more source

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway[S]

Journal of Lipid Research, 2019
Fatty acid translocase cluster of differentiation (CD36) is a multifunctional membrane protein that facilitates the uptake of long-chain fatty acids. Lipophagy is autophagic degradation of lipid droplets.
Yun Li, Ping Yang, Lei Zhao, Yao Chen, Xiaoyu Zhang, Shu Zeng, Li Wei, Zac Varghese, John F. Moorhead, Yaxi Chen, Xiong Z. Ruan   +10 more
doaj   +1 more source

MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice

Lipids in Health and Disease
Background Lipid droplet (LD)-laden microglia is a key pathological hallmark of multiple sclerosis. The recent discovery of this novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for increased inflammatory factor secretion
Hao Ma, Zhi-lin Ou, Nima Alaeiilkhchi, Yong-quan Cheng, Kai Chen, Jia-yu Chen, Ru-qin Guo, Min-yue He, Shi-yi Tang, Xin Zhang, Zhi-ping Huang, Junhao Liu, Jie Liu, Qing-an Zhu, Zu-cheng Huang, Hui Jiang   +15 more
doaj   +1 more source

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Cell Reports, 2019
Summary: Autophagy plays a broad role in health and disease. Here, we show that inositol polyphosphate multikinase (IPMK) is a prominent physiological determinant of autophagy and is critical for liver inflammation and regeneration.
Prasun Guha, Richa Tyagi, Sayan Chowdhury, Luke Reilly, Chenglai Fu, Risheng Xu, Adam C. Resnick, Solomon H. Snyder   +7 more
doaj   +1 more source

Emerging Roles of Lipophagy in Cancer Metastasis

, 2022
Obesity is a prominent risk factor for certain types of tumor progression. Adipocytes within tumor stroma contribute to reshaping tumor microenvironment (TME) and the metabolism and metastasis of tumors through the production of cytokines and adipokines.
Shan, Ying, Haimeng Yin, Ji, Yan, Tian Xia, Bo You, Yin, Haimeng, Yiwen You, Yan Ji, Ying Shan, Ling Yuan, Yuan, Ling, You, Bo, Xia, Tian, You, Yiwen   +13 more
core   +1 more source