Results 91 to 100 of about 6,137 (162)

Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells

, 2017
Ethanol-induced hepatic lipophagy plays an important cytoprotective role against liver injury, but its mechanism is not fully determined. In the present study, ethanol-induced lipophagy was studied in an immortalized mouse hepatocyte line, AML12.
Yin, Xiao-Ming, Shengmin Yan, Lee, Chao-Hung, Jun Zhou, Yan, Shengmin, Zhou, Jun, Xiao-Ming Yin, Chao-Hung Lee, Lin Wang, Wang, Lin, Lei, Guangsheng, Guangsheng Lei   +11 more
core   +1 more source

Therapeutic potential of natural medicines in diabetic kidney disease: restoring lipid homeostasis via lipophagy modulation

Frontiers in Pharmacology
Diabetic kidney disease (DKD), one of the most prevalent microvascular complications of diabetes mellitus, is characterized by a complex pathogenesis in which lipid metabolism dysregulation plays a central role.
Junwei Gao, Yunzhou Wu, Xudong Cai, Hailing Zhao, Jie Xing   +4 more
doaj   +1 more source

Quercetin improves hepatic lipid accumulation by up-regulating lipolysis and lipophagy pathways

陆军军医大学学报
Objective To investigate the effect and mechanism of quercetin (QUE) in improving lipid accumulation in hepatocytes by regulating lipolysis and lipophagy pathway.
ZHANG Yan, YANG Yilin, YUAN Jiaqi
doaj   +1 more source

Emerging role of natural lipophagy modulators in metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a seriously increasing liver disorder affecting nearly 32% of adults globally.
Kame, Asmaa A., Al-Ashmawy, Ghada M., Elashmawy, Nahla, Khedr, Eman G.   +3 more
core   +1 more source

TM9SF1 drives the lipophagic flux via AMPK-ULK1 signaling to sustain metabolic fitness in HER2-positive breast cancer

Cell Death and Disease
Therapeutic resistance and recurrence in human epidermal growth factor receptor 2-positive breast cancer (HER2 + BC) remain critical challenges that portend poor patient outcomes.
Xiaofen Li, Xiaoqin Yu, Kaiyan Huang, Xin Yu, Shiping Luo, Xiewei Huang, Chuangui Song   +6 more
doaj   +1 more source

Characterization of Vlf1 as a regulator of lipophagy.

Lipid droplets (LDs) are unique organelles, surrounded by a phospholipid monolayer. They are present in most eukaryotic cells including the unicellular model organism S. cerevisiae.
Olga Beresh, Boris Macek, Kai Stefan Dimmer, Parijat Dutta, Claudia Cavarischia-Rega, Simeon Reichert, Doron Rapaport, Brian Russell Glueck, Zacharias Fakih, Maya Schuldiner   +9 more
core   +1 more source

FOXO3/Rab7-Mediated Lipophagy and Its Role in Zn-Induced Lipid Metabolism in Yellow Catfish (Pelteobagrus fulvidraco)

Lipophagy is a selective autophagy that regulates lipid metabolism and reduces hepatic lipid deposition. However, the underlying mechanism has not been understood in fish.
Wuxiao Zhang, Chuan Chen, Fei Xiao, Kun Wu, Jiawei Wang   +4 more
core   +1 more source

Forced lipophagy reveals that lipid droplets are required for early embryonic development in mouse

Although autophagy is classically viewed as a non-selective degradation system, recent studies have revealed that various forms of selective autophagy also play crucial physiological roles.
Ishii, Shunsuke, 494361, 辰巳, 嵩征, Matsuura, Akira, Kubota, Toshiro, Itakura, Eisuke, 494373, Yamamoto, Atsushi, Takayama, Kaori, 辰巳 嵩征, 494372, 494371, 494370, Minami, Naojiro, Miyasaka, Naoyuki, 494369, 494368, 494367, 塚本, 智史, 494366, 494365, 494364, 494363, 494362, 塚本 智史, Hara, Taichi   +25 more
core  

Identification of Lipophagy-Related Gene Signature for Diagnosis and Risk Prediction of Alzheimer’s Disease

Background: Recent research indicates that lipid metabolism and autophagy play crucial roles in the development of Alzheimer’s disease (AD).
Hongxiu Guo, Shangqi Sun, Xiufeng Wang, Gang Li, Rong Ma, Yang Yang, Siyi Zheng, Xueying Shi   +7 more
core   +1 more source

Identification and verification of the key genes, CCR1 and EGR2, in diabetes-associated lipophagy

Scientific Reports
Diabetes remains a significant global health challenge, marked by increasing incidence and a complex pathophysiological mechanism involving dysregulated lipid metabolism, impaired autophagy, and chronic inflammatory responses.
Jiongjiong Liu, Xiao Zhang, Yanlei Wang, Wenjun Pei, Qiu Zhang   +4 more
doaj   +1 more source