Results 61 to 70 of about 16,571 (204)
Progress in Fishery Sciences, 2023 The Ras-related proteins in brain (Rab) subfamily is the largest group of small molecule guanine nucleotide-binding regulatory proteins (GTP-binding proteins).
Xinlin SONG +5 more
doaj +1 more source
Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling
Advanced Science, EarlyView.Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha +13 more
wiley +1 more source
Lysosome-associated miniSOG as a photosensitizer for mammalian cells
BioTechniques, 2016 Genetically encoded photosensitizers represent a promising optogenetic tool for the induction of light-controlled oxidative stress strictly localized to a selected intracellular compartment.
Alina P. Ryumina +6 more
doaj +1 more source
Differences in endosomal Rab gene expression between positive and negative COVID-19 patients
BMC Research Notes, 2022 Objective SARS CoV-2, the etiologic agent of coronavirus disease-2019 (COVID-19) is well-known to use ACE2 to begin internalization. Some viruses enter the host cell through the endocytosis process and involve some endocytosis proteins, such as the Rab ...
Nur Atik +4 more
doaj +1 more source
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Synthese und biologische Evaluierung semi-synthetischer Rab7-Proteine [PDF]
, 2003 In der vorliegenden Arbeit wurden lipidierte, fluoreszenzmarkierte Peptide synthetisiert. Die Peptide entsprechen weitgehend dem C-terminalen Bereich des im intrazellulären Vesikeltransport regulativ wirkenden membrangebundenen Rab7-Proteins.
Heinemann, Ines
core +1 more source
, 2023 (A) HeLa S3 cells were transfected with siNC, siRab9a or siTBC1D5. At 48 h after transfection, lysates were pulled down with GST or GST-RILP (IP) and subjected to Western blot analysis together with samples not pulled down (input) using antibodies ...
Jeongjoon Choi (163948) +1 more
core +1 more source
Cells, 2022 Dysfunctional autophagy is linked to neuronal damage in ischemia/reperfusion injury. The Ras-related protein 7 (Rab7), a member of the Rab family of small GTPases, appears crucial for the progression of the autophagic flux, and its activity is strictly ...
Francesca Luchetti +9 more
doaj +1 more source
Advanced Science, EarlyView.The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng +6 more
wiley +1 more source
Nature CommunicationsSARS-CoV-2, the causative agent of COVID-19, uses the host endolysosomal system for entry, replication, and egress. Previous studies have shown that the SARS-CoV-2 virulence factor ORF3a interacts with the lysosomal tethering factor HOPS complex and ...
Kshitiz Walia +7 more
doaj +1 more source