Results 71 to 80 of about 16,571 (204)
Advanced Science, EarlyView.Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao +7 more
wiley +1 more source
Rab7 controls the formation of giant endosomes.
, 2019 (A, B) Quantification of the vacuoles (A, arrows) percentage of Caco2MYO5B–/–cells expressing GFP-rab7-WT or GFP-rab7-T22N. N = 3 independent experiments. Values for each data point can be found in S8 Data. Student t test, *p p < 0.001.
Inge S. Zuhorn (1954618) +9 more
core +1 more source
Post-translational modifications: How to modulate Rab7 functions [PDF]
Small GTPases, 2017 The small GTPase Rab7 is the main regulator of membrane trafficking at late endosomes. This small GTPase regulates endosome-to-trans Golgi Network trafficking of sorting receptors, membrane fusion of late endosomes to lysosomes, and autophagosomes to lysosomes during autophagy. Rab7, like all Rab GTPases, binds downstream effectors coordinating several
Graziana Modica, Stephane Lefrancois
openaire +3 more sources
Human Rab7 mutation mimics features of Charcot–Marie–Tooth neuropathy type 2B in Drosophila
Neurobiology of Disease, 2014 Charcot–Marie–Tooth disease type 2B (CMT2B) is an inherited axonal peripheral neuropathy. It is characterised by prominent sensory loss, often complicated by severe ulcero-mutilations of toes or feet, and variable motor involvement. Missense mutations in
Katrien Janssens +8 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley +1 more source
mTOR controls lysosome function by modulating the Rab7 GTPase
, 2017 Mammalian target of rapamycin (mTOR) is a protein kinase that integrates signals including stress and nutrient availability, to modulate the metabolic state of the cell.
Zechariah Martin (10852302)
core +1 more source
Rab4 and Rab7 Define Distinct Nonoverlapping Endosomal Compartments [PDF]
Journal of Biological Chemistry, 1996 Several Rab GTPases have been localized to distinct compartments of the endocytic pathway. Rab4 is associated with early endosomes and recycling vesicles and regulates membrane recycling from early endosomes. Rab7 is localized to late endosomes and is involved in the regulation of membrane transport between late endosomes and lysosomes.
G, Bottger +2 more
openaire +2 more sources
Cytoskeleton, EarlyView.ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith +9 more
wiley +1 more source
Food Biomacromolecules, EarlyView.Non‐animal extracellular vesicles as bioactive‐compound carriers: compositional characteristics, engineering strategies, and biofunctions. Abstract Animal‐derived extracellular vesicles (EVs) were widely used for bioactive compound delivery but constrained by complex origins, potential immunogenicity, and pathogen contamination.
Jiahao Yu +6 more
wiley +1 more source
Rab7 regulates transport from early to late endocytic compartments in Xenopus oocytes
, 1997 Rab7 has been shown to localize to late endosomes and to mediate transport from early to late endosome/lysosome in mammalian cells and in yeast. We developed a novel assay to quantify transport from early to late endosomes using the Xenopusoocyte ...
Funato, Kouichi +5 more
core +1 more source