Results 91 to 100 of about 16,571 (204)

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Overall structure of human ORP1 ANK and Rab7 complex.

, 2019
(A) Cylindrical representation of the ORP1-Rab7 complex. The bound GTP and Mg2+ ion are shown in spheres. The disordered C-terminus of Rab7 is indicated with a dotted line. Top view of the structure is shown in the right panel.
Lingchen Tan (6298421), ChangJu Chun (6298424), Young Jun Im (2201077), Junsen Tong (6298418)   +3 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Integrated single‐cell transcriptomics reveals miR‐941 targets CLDN4 to inhibit malignant progression of thyroid cancer through the PI3K/AKT signaling pathway

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
The combined single‐cell and functional analysis depicts that miR‐941 targets CLDN4 and activates the regulatory axis that drives the malignancy of thyroid cancer through the PI3K/AKT pathway. Abstract Claudin‐4 (CLDN4), a key tight junction protein, has been implicated in tumor progression; however, its functional role and regulatory mechanisms in ...
Jinghua Zhou, Tiancheng Fu, Guoxiang Huang, Guangfeng Luo, Chengcheng Wang, Yanze Wang, Ziyang Ding, Xiarong Hu, Yudong Li, Zhen Li   +9 more
wiley   +1 more source

Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

eLife
Inflammation in ulcerative colitis is typically restricted to the mucosal layer of distal gut. Disrupted mucus barrier, coupled with microbial dysbiosis, has been reported to occur prior to the onset of inflammation.
Preksha Gaur, Yesheswini Rajendran, Bhagyashree Srivastava, Manasvini Markandey, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Aamir Suhail, Shikha Chaudhary, Shaifali Tyagi, Subhash Chandra Yadav, Amit Kumar Pandey, Yifat Merbl, Avinash Bajaj, Vineet Ahuja, Chittur Srikanth   +14 more
doaj   +1 more source

Phagosomes Exhibit Arrested Maturation despite Acquisition of Rab7 [PDF]

, 2000
Rab7 is a small GTPase that regulates vesicular traffic from early to late endosomal stages of the endocytic pathway. Phagosomes containing inert particles have also been shown to transiently acquire Rab7 as they mature.
Horwitz, MA, Marcus A. Horwitz, Lee, BY, Daniel L. Clemens, Bai-Yu Lee, Clemens, DL   +5 more
core   +1 more source

Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Qiao Li, Fabian Pfersdorf, Fernando Salgado‐Polo, Martin Gustavsson   +3 more
wiley   +1 more source

Rab4 Spatially and Functionally Converges With Rab7 in the Degradative Endolysosomal Network

Rab GTPases are key regulators of endosomal trafficking in eukaryotes. In mammalian cells, Rab4 and Rab7 were shown to localize to distinct compartments, with Rab4 on early endosomes for fast recycling and Rab7 on late endosomes for degradation. Here, we
Farmer, Stephen M, Xu, Shiyu, Ye, Lili, Zylberberg, German, Ye, Xin, Wang, Charissa, Moore, Travis I, Zhang, Sheng, Covarrubias, Daniela, Kanca, Oguz, Tong, Qingchun, Cai, Jing, Lin, Wen-Wen, Yu, Yue, Bellen, Hugo J, Yang, Haoyi, Rios, Beatriz, Furr-Stimming, Erin, Chuong, Vicky   +18 more
core   +1 more source

Investigations on the role of rab7 in prion infection

, 2022
Prion diseases are fatal and infectious neurodegenerative diseases caused by the misfolding of the cellular prion protein PrPc into its infectious isoform PrPSc, which comprises the main if not the only constituent of prions. In response to prion infection certain cellular impairments such as reduced membrane association of Rab7, compromised lysosomal ...
openaire   +2 more sources

AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer’s disease

Alzheimer’s Research & Therapy
Background Dysregulation retrograde axonal transport in neurons results in autophagosome accumulation, enhancing amyloid β (Aβ) production and accelerating Alzheimer’s disease (AD) progression.
Yangyang Wang, Siyu Li, Xiao Liang, Jianing Fan, Shijie Li, Fanlin Zhou, Xiaoju Li, Mengmeng Lai, Dianmao Feng, Yu Li   +9 more
doaj   +1 more source