Results 101 to 110 of about 16,571 (204)
Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7
Cell Reports, 2015 Intracellular bacterial pathogens of a diverse nature share the ability to evade host immunity by impairing trafficking of endocytic cargo to lysosomes for degradation, a process that is poorly understood.
Vanessa M. D’Costa +8 more
doaj +1 more source
STOCHASTIC DYNAMICS OF Rab5/Rab7 PROTEINS IN ENDOSOMES INFLUENCED BY MULTIPLICATIVE NOISE [PDF]
, 2023 The influence of multiplicative noise on the dynamics of active Rab5 and Rab7 proteins on the surface of endosomes has been studied. The distribution of pH (Rab5, Rab7) values in endosomes and the proportion of endosomes with pH lesser than the critical ...
Маковеева, Е. В. +3 more
core
, 2017 Regulation of protein homeostasis (“proteostasis”) is necessary for maintaining healthy cells. Disturbances in proteostasis lead to aggregates, cellular stress and can result in toxicity.
C.C. Yap +4 more
core +1 more source
Endosomes Labeled with Two Markers Show Presence of Rab7 in Early Endosomes
, 2013 Vero cells were fixed and viewed by confocal microscopy. (A) Confocal microscopy of immunolabeled cells using anti-EEA1 (green) and anti-Rab7 (red) antibodies, (B–F) The cells were transfected with fluorescent-protein-labeled ...
Andreas Vonderheit (124) +1 more
core +1 more source
Detection of Activated Rab7 GTPase with an Immobilized RILP Probe
, 2009 The dynamic and coordinated exchange of multiple GTPases between the cytosol and the phagosome membrane represents a critical process during phagosome biogenesis.
Deghmane AE +3 more
core +2 more sources
Targeting Rab7‐Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy
Advanced ScienceDiabetic cardiomyopathy (DbCM) is characterized by diastolic dysfunction, which progresses into heart failure and aberrant electrophysiology in diabetic patients.
Jiahan Ke +7 more
doaj +1 more source
Phagosomes from p110α deficient cells recruit Rab7 and its effectors, RILP and HOPS.
, 2013 A)Phagosomes from p110α knockdown cells are not defective in the recruitment of Rab7. Western blots of bead phagosome lysates (4 hours) isolated from control and p110α knockdown cells show no significant differences in recruitment of Rab7. Actin is shown
Neil E. Reiner (89181) +2 more
core +1 more source
, 2019 (A, C)w* and crbP13A9 retinas, respectively, under 5 days normal light conditions (12h light, 12h dark) show some overlap of large endogenous Rab7-carrying vesicles (green) with Arl8 (red) (arrowhead).
Elisabeth Knust (262500) +1 more
core +1 more source
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Nature Communications, 2016 Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia +13 more
doaj +1 more source
Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation
eLifeThe spatiotemporal transition of small GTPase Rab5 to Rab7 is crucial for early-to-late endosome maturation, yet the precise mechanism governing Rab5-to-Rab7 switching remains elusive.
Yue Miao +9 more
doaj +1 more source