Results 111 to 120 of about 16,571 (204)

Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells

Cell Communication and Signaling
Background RAB7 is a small GTPase with multiple cellular roles, regulating late endocytic trafficking and lysosomal biogenesis, influencing mitochondria-lysosome crosstalk, and contributing to many mitochondrial processes.
Giulia Girolimetti, Sinforosa Gagliardi, Paola Cordella, Grazia Bramato, Riccardo Di Corato, Roberta Romano, Flora Guerra, Cecilia Bucci   +7 more
doaj   +1 more source

Effect of MEHP on testosterone synthesis via Sirt1/Foxo1/Rab7 signaling pathway inhibition of lipophagy in TM3 cells

Ecotoxicology and Environmental Safety
Mono-2-ethylhexyl phthalic acid (MEHP) is the most toxic metabolite of the plasticizer di-2-ethylhexyl phthalic acid (DEHP), and studies have shown that MEHP causes serious reproductive effects. However, its exact mechanisms of action remain elusive.
Yu Hao, Xuan'en Tian, Fengmei Yan, Xiuqin Wang, Jing Huang, Ling Li   +5 more
doaj   +1 more source

Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells

Cell Communication and Signaling
Background Among the mechanisms of mitochondrial quality control (MQC), generation of mitochondria-derived vesicles (MDVs) is a process to avoid complete failure of mitochondria determining lysosomal degradation of mitochondrial damaged proteins. In this
Sinforosa Gagliardi, Marco Mitruccio, Riccardo Di Corato, Roberta Romano, Alessandra Aloisi, Rosaria Rinaldi, Pietro Alifano, Flora Guerra, Cecilia Bucci   +8 more
doaj   +1 more source

Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth

Frontiers in Oncology
RAB7, encoded by RAB7A in humans and Rab7 in mice, is a small GTPase that catalyzes endosome maturation. It mediates NF-κB activation through the assembly of intracellular membrane signalosomes in stimulated normal B cells and plays a B cell-intrinsic ...
Maria Fernandez, Rui Wang, Jingwei Wang, Shuai Wu, Kenneth Holder, Alia Nazarullah, Ricardo C. T. Aguiar, Ricardo C. T. Aguiar, Zijun Y. Xu-Monette, Zijun Y. Xu-Monette, Ken H. Young, Ken H. Young, Hui Yan, Zhenming Xu   +13 more
doaj   +1 more source

Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism [PDF]

, 2020
Endocytosis has been proposed to modulate cell signaling activities. However, the role of endocytosis in embryogenesis, which requires coordination of multiple signaling inputs, has remained less understood.
髙岡, 勝吉, 362969/profile-ja.html, カワムラ, ノブユキ, Sun-Wada, Ge-Hong, Hamada, Hiroshi, ワダ, ヨウ, Takaoka, Katsuyoshi, ハマダ, ヒロシ, Wada, Yoh, 90551044, Kawamura, Nobuyuki, 999, タカオカ, カツヨシ, Hadjantonakis, Anna-Katerina   +13 more
core  

Progression of SFV through Endosomes Labeled for EEA1 and Rab7

, 2013
(A) Confocal microscopy of Vero cells. SFV-Cy5 was allowed to bind to Vero cells (at a MOI of 20) for 60 min at 4 °C, followed by transfer to 37 °C and fixed after different times (a, 0 min; b, 10 min; c, 20 min; d, 30 min) and immunolabeled with EEA1 ...
Andreas Vonderheit (124), Ari Helenius (125)   +1 more
core   +1 more source

Coordination between ESCRT function and Rab conversion during endosome maturation

The EMBO Journal
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5 positive early endosomes receive proteins from the plasma membrane.
Daniel P Ott, Samit Desai, Jachen A Solinger, Andres Kaech, Anne Spang   +4 more
doaj   +1 more source

ML098 enhances intracellular bacterial clearance in bladder epithelial cells by activating Rab7 and promoting lysosomal biogenesis

Bangladesh Journal of Pharmacology
The aim of this study was to investigate the effect of ML098 on the intra-cellular bacterial count of bladder epithelial cells infected with uropathogenic Escherichia coli.
Hao Yin, Jiaoli Zhu, Jiamin Yin, Yi Xue, Xin Wang   +4 more
doaj   +1 more source

The roles of Rab7 on yolk granule biogenesis in vitellogenic oocytes.

Confocal fluorescent microscopy and DIC imaging of stage 10 egg chambers with ectopic expression of (A-D) wildtype YFP-Rab7 or (E-H) constitutive active (CA) YFP-Rab7-CA in oocytes that are (A-F) co-labeled for anti-GFP (green), F-Actin and (A, B) anti ...
Shiyu Xu (9662931), Dongsheng Chen (12321), Lili Ye (636327), Yue Yu (260119), Beatriz Rios (17904520), Amanda Solbach (13118998), Sheng Zhang (111330), Xin Ye (208347), Stephen M. Farmer (9269440)   +8 more
core   +1 more source

Molecular and functional mapping of Plekhm1-Rab7 interaction in osteoclasts

JBMR Plus
Abstract Mutations in PLEKHM1 cause osteopetrosis in humans and rats. The germline and osteoclast conditional deletions of Plekhm1 gene in mice lead to defective osteoclast bone resorption and increased trabecular bone mass without overt abnormalities in other organs.
Bhaba K, Das, Tarun, Minocha, Mikaela D, Kunika, Aarthi, Kannan, Ling, Gao, Subburaman, Mohan, Weirong, Xing, Kottayil I, Varughese, Haibo, Zhao   +8 more
openaire   +2 more sources