Results 31 to 40 of about 16,571 (204)

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

eLife, 2014
Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene products mutated in Parkinson’s disease, PINK1, and Parkin have been found to play a central role in triggering mitophagy in mammals, how the pre-autophagosomal isolation ...
Koji Yamano, Adam I Fogel, Chunxin Wang, Alexander M van der Bliek, Richard J Youle   +4 more
doaj   +1 more source

Rubicon controls endosome maturation as a Rab7 effector [PDF]

Proceedings of the National Academy of Sciences, 2010
The activation and recruitment of the small GTPase Rab7 to early endosome is a critical step for early to late endosome maturation, a process that requires the class III phosphatidylinositol 3-kinase (PI3KC3) and GTPase regulators. However, the molecular mechanism underlying Rab7 activation and endosome maturation is still poorly defined.
Qiming, Sun, Wiebke, Westphal, Kwun Ngok, Wong, Irena, Tan, Qing, Zhong   +4 more
openaire   +2 more sources

The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts

Scientific Reports, 2022
We have shown previously that the lysosomal a3 isoform of the a subunit of vacuolar-type ATPase (V-ATPase) interacts with inactive (GDP-bound form) Rab7, a small GTPase that regulates late endosome/lysosome trafficking, and that a3 recruits Rab7 to ...
Naomi Matsumoto, Mizuki Sekiya, Ge-Hong Sun-Wada, Yoh Wada, Mayumi Nakanishi-Matsui   +4 more
doaj   +1 more source

Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

Molecular & Cellular Oncology, 2020
High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus.
María Paz Hernández-Cáceres, Karina Cereceda, Sergio Hernández, Ying Li, Carla Narro, Patricia Rivera, Patricio Silva, Yenniffer Ávalos, Claudia Jara, Paulina Burgos, Lilian Toledo-Valenzuela, Pablo Lagos, Flavia Cifuentes Araneda, Claudio Perez-Leighton, Cristina Bertocchi, Deborah J. Clegg, Alfredo Criollo, Cheril Tapia-Rojas, Patricia V. Burgos, Eugenia Morselli   +19 more
doaj   +1 more source

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export. [PDF]

, 2020
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import.
Luzio, J.P., Elsland, D.M. van, Jongsma, M.L.M., Neefjes, J.J.C., Lehner, P.J., Boomen, D.J.H. van den, Berlin, I., Sienkiewicz, A., Ilana Berlin, Marlieke L. M. Jongsma, Jacques J. C. Neefjes, Paul J. Lehner, Daphne M. van Elsland, J. Paul Luzio, Agata Sienkiewicz, Dick J. H. van den Boomen   +15 more
core   +13 more sources

FGF-mediated establishment of left-right asymmetry requires Rab7 function in the dorsal mesoderm in Xenopus

Frontiers in Cell and Developmental Biology, 2022
Gastrulation denotes a very important developmental process, which includes significant structural tissue rearrangements and patterning events that shape the emerging vertebrate organism.
Jennifer Kreis, Celine Marie Camuto, Carolin Charlotte Elsner, Sebastian Vogel, Philipp Vick   +4 more
doaj   +1 more source

Regulation of Endosomal Trafficking by Rab7 and Its Effectors in Neurons: Clues from Charcot–Marie–Tooth 2B Disease

Biomolecules, 2023
Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis.
Ryan J. Mulligan, Bettina Winckler
doaj   +1 more source

Investigating the Importance of RAB7 in C2C12 Myoblast Differentiation [PDF]

, 2021
Prior research has shown that autophagy and mitophagy are intimately linked to skeletal muscle differentiation and myogenesis. Recent studies show that the RAB7 cycle is crucial in multiple stages of autophagy and mitophagy; however, few studies examine ...
Thoms, James
core  

Rab7: crystallization of intact and C-terminal truncated constructs complexed with GDP and GppNHp

, 1997
The GTP/GDP conformational switch of members of the rab family of ras-related GTP-ases control specific intracellular vesicle transport pathways. We report the crystallization of the late-endosomal rab protein rab7, in both GTP and GDP conformations.
Metcalf, P., Brachvogel, V., Neu, M.
core   +2 more sources

Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions

Open Medicine, 2021
Tubulointerstitial fibrosis leads to tubular basement membrane thickening and accumulation of interstitial extracellular matrix (ECM). Matrix metallopeptidase-2 (MMP-2) is involved in the breakdown of ECM.
Yu Wenmin, Ke Xiumei, Li Meiren, Ye Ping, Peng Jing, Li Huimin   +5 more
doaj   +1 more source