Results 11 to 20 of about 16,571 (204)
RAB7 GTPases as coordinators of plant endomembrane traffic [PDF]
Frontiers in Plant Science, 2023 The ras gene from rat brain (RAB) family of small GTPases is highly conserved among eukaryotes and regulates endomembrane trafficking pathways. RAB7, in particular, has been linked to various processes involved in regulating endocytic and autophagic ...
Cecilia Rodriguez-Furlan +2 more
doaj +4 more sources
Genetic mapping of the mouse Rab7 gene and pseudogene and of the human RAB7 homolog.
Mammalian Genome, 1998 Rab proteins are small GTP-ases localized to distinct membrane compartments in eukaryotic cells and regulating specific steps of intracellular vesicular membrane traffic.
BUCCI C. +11 more
core +6 more sources
Inactivation of macrophage Rab7 by Burkholderia cenocepacia [PDF]
Journal of Innate Immunity, 2010 Strains of the Burkholderia cepacia complex can survive within macrophages by arresting the maturation of phagocytic vacuoles. The bacteria preclude fusion of the phagosome with lysosomes by a process that is poorly understood.
Grinstein, Sergio +9 more
core +5 more sources
This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy [PDF]
Frontiers in Cell and Developmental Biology, 2018 Rab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial fission.
Christopher Stroupe
doaj +2 more sources
WDR91 is a Rab7 effector required for neuronal development [PDF]
Journal of Cell Biology, 2017 Early-to-late endosome conversion, which is essential for delivery of endosomal cargoes to lysosomes, requires switching of early endosome–specific Rab5 and PtdIns3P to late endosome–specific Rab7 and PtdIns(3,5)P2.
Xin Wang +11 more
core +3 more sources
Phylogeny and evolution of Rab7 and Rab9 proteins [PDF]
BMC Evolutionary Biology, 2009 Background An important role in the evolution of intracellular trafficking machinery in eukaryotes played small GTPases belonging to the Rab family known as pivotal regulators of vesicle docking, fusion and transport.
Wyroba Elżbieta, Mackiewicz Paweł
doaj +3 more sources
Structural basis of human ORP1-Rab7 interaction for the late-endosome and lysosome targeting.
PLoS ONE, 2019 Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute a family of lipid transfer proteins conserved in eukaryotes. ORP1 transports cholesterol at the interface between the late endosomes/lysosomes (LELs) and the endoplasmic ...
Junsen Tong +3 more
doaj +2 more sources
Biochemical Society Transactions, 2009 The CMT2B (Charcot-Marie-Tooth type 2B) disease is an autosomal dominant axonal neuropathy. Sensory loss, distal muscle weakness and wasting, frequent foot ulcers and amputations of the toes due to frequent infections characterize this neuropathy.
F. Piro +4 more
core +5 more sources
Rab7: a key to lysosome biogenesis.
Molecular Biology of the Cell, 2000 The molecular machinery behind lysosome biogenesis and the maintenance of the perinuclear aggregate of late endocytic structures is not well understood.
P. THOMSEN +8 more
core +5 more sources
PLoS ONE, 2011 The endo-lysosomal pathway is essential for intracellular transport and the degradation of extracellular cargo. The relationship between three populations of endo-lysosomal vesicles--Rab7-positive, LAMP1-positive, and both Rab7- and LAMP1-postive--was ...
William H Humphries +2 more
doaj +2 more sources