Results 91 to 100 of about 17,555 (209)

Effects of S. aureus on vinculin-Rab5 binding and Rab5-GTP.

, 2014
(A) S. aureus was added to the medium of HA-Rab5 (WT)-transfected Cos-7 cells and incubated with S. aureus for the indicated time at 37°C. The cells were lysed and subjected to immunoprecipitation with anti-HA antibody.
Makoto Hagiwara (513898), Kazuyuki Ishihara (513907), Yoshiko Kato (513905), Misako Nakashima (293062), Eitoyo Kokubu (513899), Shinsuke Sugiura (513900), Toshinori Komatsu (513901), Kenji Matsushita (513908), Kaoru Kobayashi (226862), Naoyuki Ishida (513906), Hiroyuki Tada (513902), Naomi Tanigawa (513904), Ryutaro Isoda (513903)   +12 more
core   +1 more source

Study of the role of RAB5-interacting proteins in endocytosis in endothelial cells: study of the role of the interaction between Rab5 and ACAT2 in endocytosis

, 2020
Endocytosis is a complex process via which segments of the plasma membrane and extracellular nutrients are internalized via vesicular carriers towards the endolysosomal system. This trafficking pathway is subject to regulation by Rab GTPases.
Γαλανοπούλου, Αικατερίνη, Galanopoulou, Aikaterini, Αικατερίνη Γαλανοπούλου   +2 more
core   +1 more source

TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway

Cancer Cell International, 2019
Background Triple negative breast cancer (TNBC) is a breast cancer (BC) subtype that is characterized by its strong invasion and a high risk of metastasis. However, the specific mechanisms underlying these phenotypes are unclear. TUFT1 plays an important
Weiguang Liu, Jianjun Han, Sufang Shi, Yuna Dai, Jianchao He   +4 more
doaj   +1 more source

The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

Scientific Reports, 2020
Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and invasion, and that these events ...
Solange Rivas, Patricio Silva, Montserrat Reyes, Hugo Sepúlveda, Luis Solano, Juan Acuña, Marisol Guerrero, Manuel Varas-Godoy, Andrew F. G. Quest, Martín Montecino, Vicente A. Torres   +10 more
doaj   +1 more source

Iron Homeostasis and Liver Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Iron is an essential micronutrient whose ability to cycle between ferric (Fe3+) and ferrous (Fe2+) states makes it crucial for physiological processes, including oxygen transport, DNA synthesis, and oxidative phosphorylation. However, because both deficiency and excess can cause severe pathology, precise regulation is critical. The liver plays
Peng Yang, Zhitian Shi, Qin Huang, Zhihong Tu, Yue Sun, Lin Wang, Yonglong Wei   +6 more
wiley   +1 more source

A Rab5 GTPase module is important for autophagosome closure

PLOS Genetics, 2017
In the conserved autophagy pathway, the double-membrane autophagosome (AP) engulfs cellular components to be delivered for degradation in the lysosome. While only sealed AP can productively fuse with the lysosome, the molecular mechanism of AP closure is currently unknown. Rab GTPases, which regulate all intracellular trafficking pathways in eukaryotes,
Fan Zhou, Shenshen Zou, Yong Chen, Zhanna Lipatova, Dan Sun, Xiaolong Zhu, Rui Li, Zulin Wu, Weiming You, Xiaoxia Cong, Yiting Zhou, Zhiping Xie, Valeriya Gyurkovska, Yutao Liu, Qunli Li, Wenjing Li, Jie Cheng, Yongheng Liang, Nava Segev   +18 more
openaire   +4 more sources

FgVps9, a Rab5 GEF, Is Critical for DON Biosynthesis and Pathogenicity in Fusarium graminearum

Frontiers in Microbiology, 2020
Rab GTPases play an important role in vesicle-mediated membrane trafficking in eukaryotes. Previous studies have demonstrated that deletion of RAB5/VPS21 reduces endocytosis and virulence of fungal phytopathogens in their host plants.
Chengdong Yang, Chengdong Yang, Jingjing Li, Jingjing Li, Xin Chen, Xin Chen, Xingzhi Zhang, Xingzhi Zhang, Danhua Liao, Danhua Liao, Yingzi Yun, Wenhui Zheng, Yakubu Saddeeq Abubakar, Guangpu Li, Zonghua Wang, Zonghua Wang, Zonghua Wang, Jie Zhou, Jie Zhou   +18 more
doaj   +1 more source

Modulating Adipogenesis: Key Role of Ras-related Protein Rab5 and its Effectors [PDF]

, 2018
The formation of adipocytes is a complicated process in which insulin and IGF-1 signaling pathways and numerous transcription factors control the conversion of precursor cells to mature fat cells.
Huang, Yongjun
core   +1 more source

Vesicular transport of a ribonucleoprotein to mitochondria

Biology Open, 2014
Intracellular trafficking of viruses and proteins commonly occurs via the early endosome in a process involving Rab5. The RNA Import Complex (RIC)-RNA complex is taken up by mammalian cells and targeted to mitochondria.
Joyita Mukherjee, Biraj Mahato, Samit Adhya   +2 more
doaj   +1 more source

Expression profile of Rab5, Rab7, tryptophan aspartate-containing coat protein, leprae lipoarabinomannan, and phenolic glycolipid-1 on the failure of the phagolysosome process in macrophages of leprosy patients as a viability marker of Mycobacterium leprae

International Journal of Mycobacteriology, 2016
Objective/Background: Phagolysosome process in macrophage of leprosy patients' is important in the early phase of eliminating Mycobacterium leprae invasion.
Cita Rosita Sigit Prakoeswa, Ratna Wahyuni, Iswahyudi, Dinar Adriaty, Irawan Yusuf, Sutjipto, Indropo Agusni, Shinzo Izumi   +7 more
doaj   +1 more source