Results 71 to 80 of about 17,555 (209)
The regulation of Rab5 by Phosphatidylinositol 3'-Kinase [PDF]
, 2012 Rab5 (Ras-related in brain) and Rab4 are small monomeric GTPases that mediate the intracellular trafficking of endocytosed growth factor receptors. Active Rab5-GTP has low intrinsic GTP hydrolysis activity that is stimulated by GTPase activating proteins
Detillieux, Dielle
core
Rab5(Q79L) interacts with the carboxyl terminus of RUFY3 [PDF]
International Journal of Biological Sciences, 2010 The small GTPase Rab5 controls the fusogenic properties of early endosomes through activation of effector proteins. Expression of a GTPase-defective mutant, Rab5(Q79L), is known to cause formation of enlarged early endosomes. To identify proteins interacting with this GTP-bound form of active Rab5 1, we used a two-hybrid system to screen a human fetal ...
Hitomi, Yoshida +4 more
openaire +2 more sources
The sorting nexin Snx21 promotes flotillin‐mediated endocytosis
The FEBS Journal, EarlyView.In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs +9 more
wiley +1 more source
Rab5 and Rac Team Up in Cell Motility [PDF]
Cell, 2008 Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamidessi et al. (2008) show that Rab5-directed trafficking of Rac to the cell membrane is required for Rac-mediated actin assembly. Trafficking of Rac may influence the mode of cell migration during morphogenesis and cancer metastasis.
Zech, Tobias, Machesky, Laura
openaire +2 more sources
Journal of Integrative Agriculture, 2015 Nerve growth factor (NGF) binds to TrkA and forms a NGF/TrkA complex at the cell surface, which is then internalized into signaling endosomes and promotes neuronal survival and neurite outgrowth.
Yao-yao QI +5 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad +6 more
wiley +1 more source
Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse
Experimental Physiology, EarlyView.Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley +1 more source
Colocalization of pDNA with Rab5.
, 2017 (a) Typical image of pDNA and Rab5 distributions in a COS7 cell without light treatment. It was obtained with confocal microscopy. Blue arrows indicate the points of colocalization of rhodamine-labeled pDNA (red) and Rab5-GFP (green).
Chun-Chi Chang (3477179) +3 more
core +1 more source
Effect of EGF-Receptor Tyrosine Kinase Inhibitor on Rab5 Function During Endocytosis [PDF]
, 2012 Tyrosine autophosphorylation within the cytoplasmic tail of EGF-receptor is a key event, which in turn recruits several factors including Shc, Grb2 and Rin1 that are essential activities for receptor-mediated endocytosis and signaling.
Barbieri, Manuel Alejandro +4 more
core +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat +11 more
wiley +1 more source