Results 71 to 80 of about 14,125 (185)

TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway

Cancer Cell International, 2019
Background Triple negative breast cancer (TNBC) is a breast cancer (BC) subtype that is characterized by its strong invasion and a high risk of metastasis. However, the specific mechanisms underlying these phenotypes are unclear. TUFT1 plays an important
Weiguang Liu, Jianjun Han, Sufang Shi, Yuna Dai, Jianchao He   +4 more
doaj   +1 more source

FgVps9, a Rab5 GEF, Is Critical for DON Biosynthesis and Pathogenicity in Fusarium graminearum

Frontiers in Microbiology, 2020
Rab GTPases play an important role in vesicle-mediated membrane trafficking in eukaryotes. Previous studies have demonstrated that deletion of RAB5/VPS21 reduces endocytosis and virulence of fungal phytopathogens in their host plants.
Chengdong Yang, Chengdong Yang, Jingjing Li, Jingjing Li, Xin Chen, Xin Chen, Xingzhi Zhang, Xingzhi Zhang, Danhua Liao, Danhua Liao, Yingzi Yun, Wenhui Zheng, Yakubu Saddeeq Abubakar, Guangpu Li, Zonghua Wang, Zonghua Wang, Zonghua Wang, Jie Zhou, Jie Zhou   +18 more
doaj   +1 more source

SNHG15 Positively Regulates Influenza Virus Infection Through Its Association With miR‐153 and RABL2A

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Influenza viruses cause seasonal epidemics, and current vaccines do not fully protect against them. This study focuses on long non‐coding RNAs (lncRNAs), which are RNA molecules that do not code for proteins but play crucial roles in various biological processes. We identified 17 lncRNAs altered by the influenza virus.
Samuel Pushparaj, Kishore Vaddadi, Chaoqun Huang, Yurong Liang, Dao Xu, Gayan Bamunuarachchi, Prince Jhandai, Keerthana Santhosh, Elizabeth Varghese, Lin Liu   +9 more
wiley   +1 more source

Vesicular transport of a ribonucleoprotein to mitochondria

Biology Open, 2014
Intracellular trafficking of viruses and proteins commonly occurs via the early endosome in a process involving Rab5. The RNA Import Complex (RIC)-RNA complex is taken up by mammalian cells and targeted to mitochondria.
Joyita Mukherjee, Biraj Mahato, Samit Adhya   +2 more
doaj   +1 more source

The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways

Biochemistry Research International, 2020
Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking.
Wanqiong Yuan, Chunli Song
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Rab5-independent activation and function of yeast Rab7-like protein, Ypt7p, in the AP-3 pathway.

PLoS ONE, 2019
The small GTPases, Rab5 and Rab7, are key regulators at multiple stages of the endocytic/endolysosomal pathway, including fusion and maturation of endosomes. In yeast, Vps21p (Rab5 homolog) recruits a GEF for Rab7 and activates the downstream Ypt7p (Rab7
Hiroki Shimamura, Makoto Nagano, Keita Nakajima, Junko Y Toshima, Jiro Toshima   +4 more
doaj   +1 more source

Expression profile of Rab5, Rab7, tryptophan aspartate-containing coat protein, leprae lipoarabinomannan, and phenolic glycolipid-1 on the failure of the phagolysosome process in macrophages of leprosy patients as a viability marker of Mycobacterium leprae

International Journal of Mycobacteriology, 2016
Objective/Background: Phagolysosome process in macrophage of leprosy patients' is important in the early phase of eliminating Mycobacterium leprae invasion.
Cita Rosita Sigit Prakoeswa, Ratna Wahyuni, Iswahyudi, Dinar Adriaty, Irawan Yusuf, Sutjipto, Indropo Agusni, Shinzo Izumi   +7 more
doaj   +1 more source

Shigella Effector VirA Suppresses Plant Immunity by Compromising PRA1.F3‐Dependent Accumulation of FLS2 at the Plasma Membrane

Plant, Cell &Environment, Volume 49, Issue 8, Page 5267-5282, August 2026.
ABSTRACT Surface immune receptors such as flagellin‐sensitive 2 (FLS2) are critical for plant defence, and their accumulation at the plasma membrane is tightly controlled by the endomembrane system. Here, we identify the Arabidopsis thaliana prenylated Rab acceptor PRA1.F3 as a positive regulator required for efficient accumulation of FLS2 at the ...
Sung Hee Jo, Sukyoung Jung, Myoung Hui Lee, Inhwan Hwang, Jeong Mee Park   +4 more
wiley   +1 more source

Lipid turnover and GEF recruitment collectively determine Rab5 recruitment and activation during the first step of early endosome formation

Nature Communications
Early endosomes are the pivotal sorting station in eukaryotic cells. A longstanding critical question is how the small GTPase Rab5 is precisely targeted to the correct membrane to initiate early endosome formation.
Yongtao Du, Xilin Miao, Yu Gao, Yu Liang, Xue Bai, Song Dang, Zhongsheng Wu, Zhengyang An, Xinyi Zhang, Yaran Yang, Zhe Zhang, Huaqing Cai, Kangmin He   +12 more
doaj   +1 more source