Results 61 to 70 of about 17,555 (209)
Extending the ATP9A‐Related Phenotypic Spectrum: Indication of Schizophrenia Susceptibility
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT ATP9A, which belongs to the P4‐ATPase family of proteins, is involved in the efficient transport of vesicles from the Golgi apparatus to the plasma membrane, as well as the release of extracellular vesicles from human cells. In 2021, a loss‐of‐function variant of this gene was identified as being associated with a recessive neurodevelopmental ...
Camille Verebi +10 more
wiley +1 more source
RIN3 promotes RAB5 activation. (
, 2012 A) LAD2 cells transfected with control or RIN3 siRNA were stimulated with 100 ng/ml SCF for 15 minutes. Cells were lysed and activated RAB5 was pulled down using 4X-ZFYVE-GST on glutathione beads as indicated in Methods.
Noriyuki Kasahara (118270) +3 more
core +1 more source
Stochastic Model of Virus–Endosome Fusion and Endosomal Escape of pH-Responsive Nanoparticles
Mathematics, 2022 In this paper, we set up a stochastic model for the dynamics of active Rab5 and Rab7 proteins on the surface of endosomes and the acidification process that govern the virus–endosome fusion and endosomal escape of pH-responsive nanoparticles. We employ a
Sergei Fedotov +3 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley +1 more source
Dmknδ interacts with active and inactive Rab5.
, 2013 A. After capture of GST-Dmknδ5 fusion protein or GST alone on glutathione-sepharose beads, purified recombinant wild-type Rab5 (Rab5), incubated beforehand with GppNHp (active conformation) or GDP (inactive conformation), was loaded.
Emilie A. Leclerc (354838) +4 more
core +1 more source
Rab5‐dependent endocytosis of KCa2.3
The FASEB Journal, 2011 We demonstrated that recycling of KCa2.3 is dependent upon Rab35/EPI64C and RME‐1. Herein, we report our initial studies on the mechanism by which KCa2.3 is retrieved from the plasma membrane. Using a biotin ligase acceptor peptide‐tagged KCa2.3 construct, we demonstrate that expression of a dominant active Rab5 (Q79L) results in the colocalization of ...
Yajuan Gao, Daniel C Devor
openaire +1 more source
Developmental Dynamics, EarlyView.Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas +8 more
wiley +1 more source
KCa2.3 enters Rab5 positive endosomes.
, 2013 BLAP-tagged KCa2.3 was co-expressed with DsRed-tagged WT (A), S34N (B) or Q79L (C) Rab5 in HEK293 cells. KCa2.3 was labeled with streptavidin-Alexa488 and localization evaluated by confocal fluorescence after 0 or 3 hrs at 37°C.
Claudia A. Bertuccio (309866) +4 more
core +1 more source
eLife, 2021 The hematopoietic system of Drosophila is a powerful genetic model for studying hematopoiesis, and vesicle trafficking is important for signal transduction during various developmental processes; however, its interaction with hematopoiesis is currently ...
Shichao Yu, Fangzhou Luo, Li Hua Jin
doaj +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro +14 more
wiley +1 more source