Results 41 to 50 of about 17,555 (209)
A conserved and regulated mechanism drives endosomal Rab transition
eLife, 2020 Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation,
Lars Langemeyer +8 more
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Differences in endosomal Rab gene expression between positive and negative COVID-19 patients
BMC Research Notes, 2022 Objective SARS CoV-2, the etiologic agent of coronavirus disease-2019 (COVID-19) is well-known to use ACE2 to begin internalization. Some viruses enter the host cell through the endocytosis process and involve some endocytosis proteins, such as the Rab ...
Nur Atik +4 more
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Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes. [PDF]
PLoS Biology, 2005 Semliki forest virus (SFV) is internalized by clathrin-mediated endocytosis, and transported via early endosomes to late endosomes and lysosomes. The intracellular pathway taken by individual fluorescently labeled SFV particles was followed using ...
Andreas Vonderheit, Ari Helenius
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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons
Neural Regeneration ResearchRab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular ...
Jiantao Cui +4 more
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PLoS ONE, 2014 Tropheryma whipplei, the agent of Whipple's disease, inhibits phago-lysosome biogenesis to create a suitable niche for its survival and replication in macrophages. To understand the mechanism by which it subverts phagosome maturation, we used biochemical
Giovanna Mottola +6 more
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Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5 [PDF]
, 1998 Rab5-dependent endosome fusion is sensitive to the phosphoinositide 3-kinase inhibitor, wortmannin. It has been proposed that phosphoinositide 3-kinase activity may be required for activation of rab5 by influencing its nucleotide cycle such as to promote
Alexandrov, K +4 more
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Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activation
Frontiers in Cell and Developmental BiologyRab5 is a key regulator of early endosomal traffic and fusion. It shares its localization and guanine nucleotide exchange factor Rabex-5 with the less characterized member of the Rab5 subfamily Rab21.
Francisco Yanguas, Cinzia Progida
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Direct binding of vinculin and Rab5.
, 2014 (A) Endogenous vinculin and Rab5 were immunoprecipitated from Cos-7 lysates with anti-Rab5 or anti-vinculin antibodies. Vinculin and Rab5 were assayed by western blotting using specific antibodies to vinculin and Rab5.
Makoto Hagiwara (513898) +12 more
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Evidence for a symmetrical requirement for Rab5-GTP in in vitro endosome-endosome fusion
, 1998 Early endosome fusion, which has been extensively characterized using an in vitro reconstitution assay, is Rab5-dependent. To examine the requirement for Rab5 on both fusion partners, we prepared cytosol and endosomes depleted of Rab5.
Stahl, D. Philip +13 more
core +1 more source
Rab5 Association with the Angiotensin II Type 1A Receptor Promotes Rab5 GTP Binding and Vesicular Fusion [PDF]
Journal of Biological Chemistry, 2002 Previous studies have demonstrated that the internalization of the angiotensin II type 1A receptor (AT(1A)R) may be mediated by both beta-arrestin-sensitive and -insensitive mechanisms. Therefore, we have used the AT(1A)R carboxyl-terminal tail to screen a rat brain yeast two-hybrid expression library for novel AT(1A)R-interacting proteins that might ...
Jennifer L, Seachrist +6 more
openaire +2 more sources