Results 21 to 30 of about 17,555 (209)

Assessing Rab5 Activation in Health and Disease [PDF]

, 2021
The endocytic pathway is a system of dynamically communicating vesicles, known as early endosomes, that internalize, sort, and traffic nutrients, trophic factors, and signaling molecules to sites throughout the cell. In all eukaryotic cells, early endosome functions are regulated by Rab5 activity, dependent upon its binding to GTP, whereas Rab5 bound ...
Anna, Pensalfini, Ying, Jiang, Seonil, Kim, Ralph A, Nixon   +3 more
openaire   +2 more sources

Identification of the Rab5 Binding Site in p110β: Assays for PI3Kβ Binding to Rab5 [PDF]

, 2015
Isoform-specific signaling by Class IA PI 3-kinases depends in part on the interactions between distinct catalytic subunits and upstream regulatory proteins. From among the class IA catalytic subunits (p110α, p110β, and p110δ), p110β has unique properties.
Rachel S, Salamon, Hashem A, Dbouk, Denise, Collado, Jaclyn, Lopiccolo, Anne R, Bresnick, Jonthan M, Backer   +5 more
openaire   +2 more sources

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice [PDF]

, 2009
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Paape, Daniel, Blackburn, Clare, Lippuner, C., Smith, Andrew, Smith, A. J., Paterou, A., Brand, J., Richardson, Melville, Richardson, M., Blackburn, C., Andrew J. Smith, Volker Brinkmann, Brinkmann, Volker, Janko Brand, Smith, A., Brinkmann, V., Daniel Paape, Toni Aebischer, Brand, Janko, Hoffmann, Kirstin, Hoffmann, K., Athina Paterou, Kirstin Hoffmann, Aebischer, Toni, Paterou, Athina, Paape, D., Clare Blackburn, Melville Richardson, Aebischer, T., Christoph Lippuner, Lippuner, Christoph   +30 more
core   +1 more source

On the Role of Rab5 in Cell Migration

Current Molecular Medicine, 2014
Uncontrolled endosome trafficking is a common feature of certain cancer cells, which has been acknowledged during the last decade. Migration and invasiveness of metastatic tumor cells are both regulated by components of the endocytic machinery, including Rab proteins.
Mendoza, P., Diaz, J., Torres, V. A.
openaire   +4 more sources

Rabaptin5 is recruited to endosomes by Rab4a and Rabex5 to regulate endosome maturation [PDF]

, 2014
Membrane trafficking between organelles is fundamental to the existence of eukaryotic cells. A multitude of proteins is involved in membrane trafficking, acting as building blocks for transport carriers, regulators of transport, and targeting and fusion ...
Kälin, Simone
core   +1 more source

rab5 GTPase Regulates Adenovirus Endocytosis [PDF]

Journal of Virology, 1999
ABSTRACT Adenovirus interaction with αv integrins is important for virus entry. We have examined the effects of adenovirus attachment on intracellular signaling in HeLa cells, with an emphasis on pathways known to be activated following integrin interaction with other ligands. We found no evidence for [Ca 2+
T, Rauma, J, Tuukkanen, J M, Bergelson, G, Denning, T, Hautala   +4 more
openaire   +2 more sources

A non-linear system patterns Rab5 GTPase on the membrane

eLife, 2020
Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors ...
Alice Cezanne, Janelle Lauer, Anastasia Solomatina, Ivo F Sbalzarini, Marino Zerial   +4 more
doaj   +1 more source

A role for Rab5 in structuring the endoplasmic reticulum [PDF]

The Journal of Cell Biology, 2007
The endoplasmic reticulum (ER) is a contiguous network of interconnected membrane sheets and tubules. The ER is differentiated into distinct domains, including the peripheral ER and nuclear envelope. Inhibition of two ER proteins, Rtn4a and DP1/NogoA, was previously shown to inhibit the formation of ER tubules in vitro. We show that the formation of ER
Audhya, Anjon, Desai, Arshad, Oegema, Karen   +2 more
openaire   +3 more sources

Influence of Mg2+ on the Structure and Function of Rab5 [PDF]

Journal of Biological Chemistry, 1996
Mg2+ inhibits GDP release from Rab5WT but not from Rab5S34N, a mutant lacking Ser34 critical for Mg2+ coordination in the nucleotide binding pocket. Thus, inhibition of GDP release is apparently exerted via coordination of Mg2+ between Rab5 and GDP. Mg2+ also induces conformational changes in Rab5WT, demonstrated by increased tryptophan fluorescence ...
J Y, Pan, J C, Sanford, M, Wessling-Resnick   +2 more
openaire   +2 more sources

The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway. [PDF]

PLoS ONE, 2011
The expression of the recently identified dermokine (Dmkn) gene leads to four families of proteins with as yet unknown functions. The secreted α, β and γ isoforms share an epidermis-restricted expression pattern, whereas the δ isoform is intracellular ...
Emilie A Leclerc, Leila Gazeilles, Guy Serre, Marina Guerrin, Nathalie Jonca   +4 more
doaj   +1 more source