Results 21 to 30 of about 14,125 (185)

A novel function of Rab5 in mitosis [PDF]

Small GTPases, 2012
Several membrane trafficking proteins have been shown to participate in spindle assembly and stability during mitosis. Despite the fact that the role of some of them has been clarified, the requirement for these molecules in mitosis is still poorly understood.
openaire   +2 more sources

Rab5-dependent autophagosome closure by ESCRT [PDF]

Journal of Cell Biology, 2019
In the conserved autophagy pathway, autophagosomes (APs) engulf cellular components and deliver them to the lysosome for degradation. Before fusing with the lysosome, APs have to close via an unknown mechanism. We have previously shown that the endocytic Rab5-GTPase regulates AP closure.
Fan Zhou, Zulin Wu, Mengzhu Zhao, Rakhilya Murtazina, Juan Cai, Ao Zhang, Rui Li, Dan Sun, Wenjing Li, Lei Zhao, Qunli Li, Jing Zhu, Xiaoxia Cong, Yixi Zhou, Zhiping Xie, Valeriya Gyurkovska, Liuju Li, Xiaoshuai Huang, Yanhong Xue, Liangyi Chen, Hui Xu, Haiqian Xu, Yongheng Liang, Nava Segev   +23 more
openaire   +2 more sources

Abnormal α-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease

Neurobiology of Disease, 2004
The present study examines α-synuclein interactions with rab3a and rabphilin by antibody arrays, immunoprecipitation and pull-down methods in the entorhinal cortex of control cases and in diffuse Lewy body disease (LBD) cases.
E Dalfó, M Barrachina, J.L Rosa, S Ambrosio, I Ferrer   +4 more
doaj   +1 more source

Rab GTPase Mediating Regulation of NALP3 in Colorectal Cancer

Molecules, 2020
The NALP3 inflammasome signaling contributes to inflammation within tumor tissues. This inflammation may be promoted by the vesicle trafficking of inflammasome components and cytokines. Rab5, Rab7 and Rab11 regulate vesicle trafficking. However, the role
Gülçin Tezcan, Ekaterina E. Garanina, Margarita N. Zhuravleva, Shaimaa Hamza, Albert A. Rizvanov, Svetlana F. Khaiboullina   +5 more
doaj   +1 more source

CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity

Cell Communication and Signaling, 2021
Background CMTM7 is a tumor suppressor that positively regulates EGFR degradation by promoting Rab5 activation, and plays a vital role in tumor progression. Rab5 forms complexes with Beclin1 and VPS34, and acts in the early stage of autophagy.
Baocai Liu, Yinliang Lu, Tingting Zhang, Xinyue Yu, Qian Wang, Yunbo Chi, Shunzi Jin, Guanghui Cheng   +7 more
doaj   +1 more source

Biogenesis of the Sorting Endosome: The Role of Rab5 [PDF]

Traffic, 2000
Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5‐interacting proteins and components of the membrane fusion apparatus.
openaire   +2 more sources

Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Rab5 is a small GTPase and a key regulator in early endosomal trafficking. Rab5 and its effectors are involved in a large number of infectious diseases and certain types of cancer.
Eileen Edler, Matthias Stein
doaj   +1 more source

Brain-Derived Neurotrophic Factor (BDNF) Regulates Rab5-Positive Early Endosomes in Hippocampal Neurons to Induce Dendritic Branching

Frontiers in Cellular Neuroscience, 2018
Neurotrophin receptors use endosomal pathways for signaling in neurons. However, how neurotrophins regulate the endosomal system for proper signaling is unknown.
Guillermo Moya-Alvarado, Andres Gonzalez, Nicolas Stuardo, Francisca C. Bronfman   +3 more
doaj   +1 more source

Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex

Frontiers in Microbiology, 2017
Classical swine fever virus (CSFV) is a fatal pig pestivirus and causes serious financial losses to the pig industry. CSFV NS4B protein is one of the most important viral replicase proteins.
Jihui Lin, Chengbao Wang, Longxiang Zhang, Tao Wang, Jing Zhang, Wulong Liang, Cheng Li, Gui Qian, Yueling Ouyang, Kangkang Guo, Yanming Zhang   +10 more
doaj   +1 more source

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

Molecular Brain, 2009
Dysfunction of alsin, particularly its putative Rab5 guanine-nucleotide-exchange factor activity, has been linked to one form of juvenile onset recessive familial amyotrophic lateral sclerosis (ALS2).
Lai Chen, Xie Chengsong, Shim Hoon, Chandran Jayanth, Howell Brian W, Cai Huaibin   +5 more
doaj   +1 more source