Results 11 to 20 of about 14,125 (185)
Vinculin and Rab5 complex is required [correction of requited]for uptake of Staphylococcus aureus and interleukin-6 expression. [PDF]
PLoS ONE, 2014 Vinculin, a 116-kDa membrane cytoskeletal protein, is an important molecule for cell adhesion; however, little is known about its other cellular functions.
Makoto Hagiwara +12 more
doaj +1 more source
A role for Rab5 in structuring the endoplasmic reticulum [PDF]
The Journal of Cell Biology, 2007 The endoplasmic reticulum (ER) is a contiguous network of interconnected membrane sheets and tubules. The ER is differentiated into distinct domains, including the peripheral ER and nuclear envelope. Inhibition of two ER proteins, Rtn4a and DP1/NogoA, was previously shown to inhibit the formation of ER tubules in vitro. We show that the formation of ER
Audhya, Anjon +2 more
openaire +3 more sources
Role of Rab5 in the formation of macrophage-derived foam cell
Lipids in Health and Disease, 2017 Background Foam cells play a key role in the occurrence and pathogenesis of atherosclerosis. Its formation starts with the ingestion of oxidized low-density lipoprotein (oxLDL).
Lokwern Chan +7 more
doaj +1 more source
Dynamin- and Rab5-dependent endocytosis of a Ca2+ -activated K+ channel, KCa2.3. [PDF]
PLoS ONE, 2012 Regulation of the number of ion channels at the plasma membrane is a critical component of the physiological response. We recently demonstrated that the Ca(2+)-activated K(+) channel, KCa2.3 is rapidly endocytosed and enters a Rab35- and EPI64C-dependent
Yajuan Gao +4 more
doaj +1 more source
On the Role of Rab5 in Cell Migration
Current Molecular Medicine, 2014 Uncontrolled endosome trafficking is a common feature of certain cancer cells, which has been acknowledged during the last decade. Migration and invasiveness of metastatic tumor cells are both regulated by components of the endocytic machinery, including Rab proteins.
Mendoza, P., Diaz, J., Torres, V. A.
openaire +4 more sources
A non-linear system patterns Rab5 GTPase on the membrane
eLife, 2020 Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors ...
Alice Cezanne +4 more
doaj +1 more source
Integration of two RAB5 groups during endosomal transport in plants
eLife, 2018 RAB5 is a key regulator of endosomal functions in eukaryotic cells. Plants possess two different RAB5 groups, canonical and plant-unique types, which act via unknown counteracting mechanisms.
Emi Ito +6 more
doaj +1 more source
The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway. [PDF]
PLoS ONE, 2011 The expression of the recently identified dermokine (Dmkn) gene leads to four families of proteins with as yet unknown functions. The secreted α, β and γ isoforms share an epidermis-restricted expression pattern, whereas the δ isoform is intracellular ...
Emilie A Leclerc +4 more
doaj +1 more source
Influence of Mg2+ on the Structure and Function of Rab5 [PDF]
Journal of Biological Chemistry, 1996 Mg2+ inhibits GDP release from Rab5WT but not from Rab5S34N, a mutant lacking Ser34 critical for Mg2+ coordination in the nucleotide binding pocket. Thus, inhibition of GDP release is apparently exerted via coordination of Mg2+ between Rab5 and GDP. Mg2+ also induces conformational changes in Rab5WT, demonstrated by increased tryptophan fluorescence ...
J Y, Pan +2 more
openaire +2 more sources
eLife, 2021 Actin filaments (F-actin) have been implicated in various steps of endosomal trafficking, and the length of F-actin is controlled by actin capping proteins, such as CapZ, which is a stable heterodimeric protein complex consisting of α and β subunits ...
Dawei Wang +6 more
doaj +1 more source