Integration of two RAB5 groups during endosomal transport in plants
eLife, 2018 RAB5 is a key regulator of endosomal functions in eukaryotic cells. Plants possess two different RAB5 groups, canonical and plant-unique types, which act via unknown counteracting mechanisms.
Emi Ito +6 more
doaj +2 more sources
Biogenesis of the sorting endosome: The role of Rab5 [PDF]
Traffic, 2000 Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5 ...
Woodman, Philip G.; id_orcid
core +3 more sources
Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria
eLife, 2018 Mitochondrial stress response is essential for cell survival, and damaged mitochondria are a hallmark of neurodegenerative diseases. Thus, it is fundamental to understand how mitochondria relay information within the cell.
FoSheng Hsu +5 more
doaj +2 more sources
Subcellular localization of SUN2 is regulated by lamin A and Rab5. [PDF]
PLoS ONE, 2011 SUN2 is an inner nuclear membrane protein with a conserved Sad1/UNC-84 homology SUN-domain at the C-terminus. Intriguingly, SUN2 has also been reported to interact with Rab5, which localizes in early endosomes.
Ying Liang +3 more
doaj +6 more sources
Rab5-independent activation and function of yeast Rab7-like protein, Ypt7p, in the AP-3 pathway.
PLoS ONE, 2019 The small GTPases, Rab5 and Rab7, are key regulators at multiple stages of the endocytic/endolysosomal pathway, including fusion and maturation of endosomes. In yeast, Vps21p (Rab5 homolog) recruits a GEF for Rab7 and activates the downstream Ypt7p (Rab7
Hiroki Shimamura +4 more
doaj +2 more sources
Rab5 GTPases are required for optimal TORC2 function [PDF]
Journal of Cell Biology, 2018 Target of rapamycin complex-2 (TORC2), a conserved protein kinase complex, is an indispensable regulator of plasma membrane homeostasis. In budding yeast (Saccharomyces cerevisiae), the essential downstream effector of TORC2 is protein kinase Ypk1 and ...
Thorner, Jeremy +3 more
core +5 more sources
SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis [PDF]
Experimental and Molecular Medicine, 2019 Intracellular transport: a new SPIN A key protein required for incorporating substances into cells has been identified by researchers in South Korea. During this process, called endocytosis, materials are engulfed by the cell membrane, then packaged into
Hwan Kim +13 more
doaj +2 more sources
Naltrexone, Naloxone, Morphine, and Fentanyl Pharmacologically Chaperone a Mutant μ-Opioid Receptor via an Endoplasmic Reticulum Exit Site-Dependent Pathway. [PDF]
Pharmacol Res PerspectABSTRACT Opioid receptor antagonists increase the plasma membrane density of μ‐opioid receptors (MOR) in vivo, thereby inducing “supersensitivity” to opioid agonists. This phenomenon increases the risk of overdose in patients that were being treated with naltrexone (Ntx), a popular MOR antagonist.
Grant SN, Mulcahy MJ, Lester HA.
europepmc +2 more sources
Interactions of rab5 with cytosolic proteins. [PDF]
Journal of Biological Chemistry, 1992 Rab proteins, one of the subfamilies of ras-like small GTP-binding proteins, are attached to cellular compartments or transport vesicles and may determine the specificity of fusion between these compartments and vesicles. It has been proposed that they alternate between a membrane-bound and a cytosolic state during their functional cycle.
Kurzchalia, Teymuras V. +7 more
openaire +3 more sources
Coordination of the Rab5 Cycle on Macropinosomes [PDF]
Traffic, 2011 The GTPase Rab5a regulates the homotypic and heterotypic fusion of membranous organelles during the early stages of endocytosis. Many of the molecules which regulate the Rab5a cycle of association with membranes, activation, deactivation and dissociation are known.
Feliciano, William David +3 more
openaire +3 more sources