Results 81 to 90 of about 17,555 (209)

Regulation of Liver Metabolism by the Endosomal GTPase Rab5

Cell Reports, 2015
The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we addressed the question of whether endosomes are required for gluconeogenic gene expression.
Zeigerer, Anja, Bogorad, Roman L., Sharma, Kirti, Gilleron, Jerome, Seifert, Sarah, Sales, Susanne, Berndt, Nikolaus, Bulik, Sascha, Marsico, Giovanni, D’Souza, Rochelle C.J., Lakshmanaperumal, Naharajan, Meganathan, Kesavan, Natarajan, Karthick, Sachinidis, Agapios, Dahl, Andreas, Holzhütter, Hermann-Georg, Shevchenko, Andrej, Mann, Matthias, Koteliansky, Victor, Zerial, Marino, Bogorad, Roman   +20 more
openaire   +7 more sources

Adrenergic Contraction of Human Prostate Tissues Is Maintained Under the Rab GTPase Inhibitors Nexhinib20 and CID1067700

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT α1‐Adrenoceptors are an important drug target in benign prostatic hyperplasia (BPH) and have been intensively studied at the expression level, but their posttranslational regulation in the prostate is widely unknown. Here we examined modulation of prostate smooth muscle contractions by inhibitors for RabGTPases, which are involved in ...
Luca Troffer, Peibin Cen, Michael Brandstetter, Yajie Xu, Patrick Keller, Leo Stadelmeier, Philipp Weinhold, Alexander Tamalunas, Christian G. Stief, Martin Hennenberg   +9 more
wiley   +1 more source

Co‐operative regulation of endocytosis by three RAB5 isoforms [PDF]

FEBS Letters, 1995
Rab proteins are small GTPases involved in the regulation of membrane traffic. Rab5a has been shown to regulate transport in the early endocytic pathway. Here we report the isolation of cDNA clones encoding two highly related isoforms, Rab5b and Rab5c. The two proteins share with Rab5a all the structural features required for regulation of endocytosis.
Bucci C, Lütcke A, SteeleMortimer O, Olkkonen, VM, Dupree P, Chiariello M, Bruni CB, Simons K, Zerial M   +9 more
openaire   +6 more sources

Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Qiao Li, Fabian Pfersdorf, Fernando Salgado‐Polo, Martin Gustavsson   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, Volume 600, Issue 19, Page 2917-2928, October 2026.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase

, 2017
Rab5 is a small monomeric GTPase that mediates protein trafficking during endocytosis. Inactivation of Rab5 by GTP hydrolysis causes a conformational change that masks binding sites on its “switch regions” from downstream effectors.
Dielle E. Whitecross, Deborah H. Anderson   +1 more
core   +1 more source

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

eLife
The spatiotemporal transition of small GTPase Rab5 to Rab7 is crucial for early-to-late endosome maturation, yet the precise mechanism governing Rab5-to-Rab7 switching remains elusive.
Yue Miao, Yongtao Du, Baolei Wang, Jingjing Liang, Yu Liang, Song Dang, Jiahao Liu, Dong Li, Kangmin He, Mei Ding   +9 more
doaj   +1 more source

Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation

Scientific Reports, 2018
The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations located within
Paul Mellor, Jeremy D. S. Marshall, Xuan Ruan, Dielle E. Whitecross, Rebecca L. Ross, Margaret A. Knowles, Stanley A. Moore, Deborah H. Anderson   +7 more
doaj   +1 more source

Huntingtin as an Actin Organizer: Structural and Functional Insights

Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
wiley   +1 more source

MVB Maturation Responsive to KRASG12D/TP53R175H Co‐mutations Fuels Extracellular Vesicle‐hypersecretion Phenotype to Aggravate Lymphangiogenesis and Lymphatic Metastasis

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
KRAS/TP53 co‐mutation specifically induces transcriptional upregulation of FUS, which mediates EVs‐circSCARNA10 secretion to anchor lymphatic endothelial cells via promoting VEGFR3 transcription, ultimately inducing lymphangiogenesis and LN metastasis of KRASG12D and TP53R175H co‐mutated PDAC.
Jiabin Yang, Yuming Luo, Yu Zhou, Mingjie An, Mingrui Pang, Zhihua Li, Qingyu Xie, Hanhao Zheng, Zhou Fang, Yao Kong, Chao Yu, Yan Lin, Dingwen Zhang, Bingxin Cao, Haoming Zhong, Changhao Chen, Rufu Chen   +16 more
wiley   +1 more source