Results 81 to 90 of about 14,125 (185)

cDNA Cloning of a Rab5 Homologue in Babesia gibsoni

Journal of Veterinary Medical Science, 2003
For studying protein trafficking in Babesia-infected erythrocyte, we describe the cloning of a Rab5, one of molecular marker for vesicle trafficking in eukaryotic cells, gene homologue in Babesia gibsoni (BgRab5). The full-length cDNA of BgRab5 is 1,020 bp long with an open reading frame encoding a protein of 220 amino acids.
ZHOU, Jinlin, OHASHI, Kazuhiko, YAMASAKI, Masahiro, ONUMA, Misao   +3 more
openaire   +3 more sources

Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic function

npj Parkinson's Disease
Parkinson’s disease (PD) is characterized by α-synuclein aggregation and perturbation of the endolysosomal network (ELN), yet the molecular mechanisms linking α-synuclein pathology to neuronal dysfunction remain unclear.
Xinxin Zuo, Zeyu Chen, Xu-Qiao Chen, Dongxu Guan, Peter X. Shaw, Aaron Johnstone, Ann Becker, Utpal Das, William C. Mobley   +8 more
doaj   +1 more source

The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.

PLoS Biology, 2004
The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally ...
Carsten Schnatwinkel, Savvas Christoforidis, Margaret R Lindsay, Sandrine Uttenweiler-Joseph, Matthias Wilm, Robert G Parton, Marino Zerial   +6 more
doaj   +1 more source

Rab5 isoforms orchestrate a "division of labor" in the endocytic network; Rab5C modulates Rac-mediated cell motility.

PLoS ONE, 2014
Rab5, the prototypical Rab GTPase and master regulator of the endocytic pathway, is encoded as three differentially expressed isoforms, Rab5A, Rab5B and Rab5C.
Pin-I Chen, Kristine Schauer, Chen Kong, Andrew R Harding, Bruno Goud, Philip D Stahl   +5 more
doaj   +1 more source

Coordination between ESCRT function and Rab conversion during endosome maturation

The EMBO Journal
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5 positive early endosomes receive proteins from the plasma membrane.
Daniel P Ott, Samit Desai, Jachen A Solinger, Andres Kaech, Anne Spang   +4 more
doaj   +1 more source

SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis

Experimental and Molecular Medicine, 2019
Intracellular transport: a new SPIN A key protein required for incorporating substances into cells has been identified by researchers in South Korea. During this process, called endocytosis, materials are engulfed by the cell membrane, then packaged into
Hwan Kim, Hyejin Oh, Young Soo Oh, Jeomil Bae, Nan Hyung Hong, Su Jung Park, Suyeon Ahn, Miriam Lee, Sangmyung Rhee, Sung Haeng Lee, Youngsoo Jun, Sung Hyun Kim, Yun Hyun Huh, Woo Keun Song   +13 more
doaj   +1 more source

Phosphatidylinositol-3-OH kinases are Rab5 effectors

Nature Cell Biology, 1999
Nat Cell ...
Christoforidis, S, Miaczynska, M, Ashman, K, Wilm, M, Zhao, LY, Yip, SC, Waterfield, MD, Backer, JM, Zerial, M   +8 more
openaire   +6 more sources

Critical role for Piccolo in synaptic vesicle retrieval

eLife, 2019
Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy.
Frauke Ackermann, Kay Oliver Schink, Christine Bruns, Zsuzsanna Izsvák, F Kent Hamra, Christian Rosenmund, Craig Curtis Garner   +6 more
doaj   +1 more source

Rab GTPases drive ligand‐independent NOTCH1 activation via altered endocytic trafficking in chronic lymphocytic leukemia

HemaSphere
Clinically relevant NOTCH1 activation is frequently observed in chronic lymphocytic leukemia (CLL), even in the absence of gene mutations, raising questions about the underlying mechanisms.
Filomena De Falco, Beatrice Del Papa, Daniele Sorcini, Letizia Valmarini, Francesco Maria Adamo, Andrea Atzeni, Angela Esposito, Estevão Carlos Silva Barcelos, Erica Dorillo, Arianna Stella, Roberta Arcaleni, Fabio Gurrieri, Miriam Pugliese, Gabriele Astolfi, Maria Paola Martelli, Mauro Di Ianni, Emanuela Rosati, Paolo Sportoletti   +17 more
doaj   +1 more source

A new role for RAB5 [PDF]

Nature Reviews Molecular Cell Biology, 2011
openaire   +1 more source