Results 171 to 180 of about 16,571 (204)
Rab7 induces clearance of α-synuclein aggregates.
Journal of Neurochemistry, 2016 Parkinson's disease can be caused by mutations in the α-synuclein gene and is characterized by aggregates of α-synuclein protein. Aggregates are degraded by the autophago-lysosomal pathway.
Aaron Voigt +2 more
exaly +4 more sources
Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167
International Journal of Molecular Sciences, 2022 Rab7 is a GTPase that controls late endosome and lysosome trafficking. Recent studies have demonstrated that Rab7 is ubiquitinated, a post-translational modification mediated by an enzymatic cascade.
Marc P Lussier +2 more
exaly +2 more sources
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Potential role of Acanthamoeba Rab7
Experimental Parasitology, 2022Acanthamoeba castellanii is a free-living protozoan that causes several severe human parasitic diseases such as Acanthamoeba keratitis and granulomatous encephalitis. A. castellanii feeds on bacteria, yeasts, and other organic particles as food sources, but the mechanisms of digestion in acanthamoebal cells are unclear.
Zih-Bin, Hong +3 more
openaire +2 more sources
Tyrosine phosphorylation of Rab7 by Src kinase
Cellular Signalling, 2017The small molecular weight GTPase Rab7 is a key regulator for late endosomal/lysosomal membrane trafficking, it was known that Rab7 is phosphorylated, but the corresponding kinase and the functional regulation of Rab7 phosphorylation remain unclear. We provide evidence here that Rab7 is a substrate of Src kinase, and is tyrosine-phosphorylated by Src ...
Tuanlao Wang, Wanjin Hong, Jiaming Zhang
exaly +3 more sources
1995
Abstract Rab7 was first identified by screening a cDNA library from BRL-3A cells (buffalo rat liver) and initially called BRL-ras (Bucci et al. 1988). Later, a cDNA library from MDCK (Madin-Darby canine kidney) cells was screened with degenerated oligonucleotides made in the conserved domains and the canine clone was isolated ...
Cecilia Bucci +2 more
openaire +3 more sources
Abstract Rab7 was first identified by screening a cDNA library from BRL-3A cells (buffalo rat liver) and initially called BRL-ras (Bucci et al. 1988). Later, a cDNA library from MDCK (Madin-Darby canine kidney) cells was screened with degenerated oligonucleotides made in the conserved domains and the canine clone was isolated ...
Cecilia Bucci +2 more
openaire +3 more sources
Maturation of autophagosomes and endosomes: A key role for Rab7
Biochimica Et Biophysica Acta - Molecular Cell Research, 2013 Macroautophagy is an important route in cellular maintenance, in the breakdown and reuse of intracellular materials. It is closely related to endocytosis, the means by which the cell can absorb extracellular material, as both macroautophagy and endocytosis have converging steps and common participating molecules.
Antero Salminen +2 more
exaly +3 more sources
Structural basis for recruitment of RILP by small GTPase Rab7 [PDF]
EMBO Journal, 2005 Rab7 regulates vesicle traffic from early to late endosomes, and from late endosomes to lysosomes. The crystal structure of Rab7-GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 interacts with RILP specifically via two distinct areas, with the first one involving the switch and interswitch regions and the second one consisting of ...
Tuanlao Wang, Wanjin Hong
exaly +3 more sources
Role of the RAB7 Protein in Tumor Progression and Cisplatin Chemoresistance [PDF]
Cancers, 2019 RAB7 is a small guanosine triphosphatase (GTPase) extensively studied as regulator of vesicular trafficking. Indeed, its role is fundamental in several steps of the late endocytic pathway, including endosome maturation, transport from early endosomes to late endosomes and lysosomes, clustering and fusion of late endosomes and lysosomes in the ...
Cecilia Bucci, Flora Guerra
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SKIP‐HOPS recruits TBC1D15 for a Rab7‐to‐Arl8b identity switch to control late endosome transport [PDF]
EMBO Journal, 2020 The endolysosomal system fulfils a myriad of cellular functions predicated on regulated membrane identity progressions, collectively termed maturation.
Jacques J.C. Neefjes +2 more
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Control of Rab5 and Rab7 Expression by the Isoprenoid Pathway
Biochemical and Biophysical Research Communications, 1998Rab proteins are small molecular mass GTP-ases involved in the regulation of vescicular transport. The ability of rab proteins to carry out their role in intracellular membrane traffic requires the post-translational attachment to their C-terminus of a geranylgeranyl group, an isoprenoid lipid moiety derived from mevalonate.
LAEZZA, CHIARA +4 more
openaire +4 more sources