Results 201 to 205 of about 23,457 (205)

A novel RAB7 mutation associated with ulcero‐mutilating neuropathy

Annals of Neurology, 2004
AbstractThere are two known autosomal dominant genes for the hereditary ulcero‐mutilating neuropathies: SPTLC1 (hereditary sensory neuropathy type 1) and RAB7 (Charcot–Marie–Tooth disease type 2B). We report a family with autosomal dominant ulcero‐mutilating neuropathy, developing in the teens and characterized by ulcers, amputations, sensory ...
Henry, Houlden, Rosalind H M, King, John R, Muddle, Thomas T, Warner, Mary M, Reilly, Richard W, Orrell, Lionel, Ginsberg   +6 more
openaire   +2 more sources

Synthesis of Fluorescently Labeled Mono- and Diprenylated Rab7 GTPase

Journal of the American Chemical Society, 2004
Modification of proteins with isoprenoid lipids is a widespread phenomenon in eukaryotic organisms that has received much attention due to its involvement in the progression of several diseases including cancer. Progress in studies of prenylated proteins has been hampered by difficulties associated with isolation of these proteins from native or ...
Durek, T., Alexandrov, K., Goody, R. S., Hildebrand, A., Heinemann, I., Waldmann, H.   +5 more
openaire   +4 more sources

Inductive Process Modeling of Rab5-Rab7 Conversion in Endocytosis

2013
Inductive process modeling (IPM) is an approach to equation discovery that can be used to induce comprehensible models of dynamical systems from observed data and domain knowledge. We apply IPM to the task of modeling the conversion of Rab5 domain proteins to Rab7 domain proteins, a key process in endocytosis.
Tanevski J., Todorovski L., Kalaidzidis Y., Dzeroski S.   +3 more
openaire   +1 more source

Control of Rab5 and Rab7 Expression by the Isoprenoid Pathway

Biochemical and Biophysical Research Communications, 1998
Rab proteins are small molecular mass GTP-ases involved in the regulation of vescicular transport. The ability of rab proteins to carry out their role in intracellular membrane traffic requires the post-translational attachment to their C-terminus of a geranylgeranyl group, an isoprenoid lipid moiety derived from mevalonate.
LAEZZA, CHIARA, Bucci, Cecilia, SANTILLO, MARIAROSARIA, BRUNI, CARMELO BRUNO, Bifulco, Maurizio   +4 more
openaire   +4 more sources

Rabring7: A Target Protein for Rab7 Small G Protein

2005
Rab7, a member of the Rab family of small G proteins, has been shown to regulate late endocytic traffic and lysosome biogenesis, but the exact roles and the mode of actions of Rab7 are still undetermined. Accumulating evidence suggests that each Rab protein has multiple target proteins and works together with them to coordinate the individual step of ...
Kouichi, Mizuno, Ayuko, Sakane, Takuya, Sasaki   +2 more
openaire   +2 more sources